Search Results - "Trainor, Kyle"

Exploring the relationships between protein sequence, structure and solubility by Trainor, Kyle, Broom, Aron, Meiering, Elizabeth M

“…[Display omitted] •Aggregation/solubility prediction methods are widely developed and used.•Choice of method may sometimes be influenced by structural…”
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Computational Modeling of Protein Stability: Quantitative Analysis Reveals Solutions to Pervasive Problems by Broom, Aron, Trainor, Kyle, Jacobi, Zachary, Meiering, Elizabeth M.

“…Accurate modeling of the effects of mutations on protein stability is central to understanding and controlling proteins in myriad natural and applied contexts…”
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Designed protein reveals structural determinants of extreme kinetic stability by Broom, Aron, Ma, S. Martha, Xia, Ke, Rafalia, Hitesh, Trainor, Kyle, Colón, Wilfredo, Gosavi, Shachi, Meiering, Elizabeth M.

“…The design of stable, functional proteins is difficult. Improved design requires a deeper knowledge of the molecular basis for design outcomes and properties…”
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Computational tools help improve protein stability but with a solubility tradeoff by Broom, Aron, Jacobi, Zachary, Trainor, Kyle, Meiering, Elizabeth M.

“…Accurately predicting changes in protein stability upon amino acid substitution is a much sought after goal. Destabilizing mutations are often implicated in…”
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Temperature dependence of NMR chemical shifts: Tracking and statistical analysis by Trainor, Kyle, Palumbo, Jeffrey A., MacKenzie, Duncan W. S., Meiering, Elizabeth M.

“…Isotropic chemical shifts measured by solution nuclear magnetic resonance (NMR) spectroscopy offer extensive insights into protein structure and dynamics…”
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A Descriptor Set for Quantitative Structure‐property Relationship Prediction in Biologics by Sankar, Kannan, Trainor, Kyle, Blazer, Levi L., Adams, Jarrett J., Sidhu, Sachdev S., Day, Tyler, Meiering, Elizabeth, Maier, Johannes K. X.

“…There has been a remarkable increase in the number of biologics, especially monoclonal antibodies, in the market over the last decade. In addition to attaining…”
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The Italian identities for Hilbert series of hypergraphs by Brennan, Joseph P., Trainor, Kyle

“…Given a graph with loops or a hypergraph, this paper demonstrates that the Hilbert series of the associated graph or hypergraph ring is determined by the…”
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Design for Solubility May Reveal Induction of Amide Hydrogen/Deuterium Exchange by Protein Self-Association by Trainor, Kyle, Doyle, Colleen M., Metcalfe-Roach, Avril, Steckner, Julia, Lipovšek, Daša, Malakian, Heather, Langley, David, Krystek Jr, Stanley R., Meiering, Elizabeth M.

“…[Display omitted] •Adnectin scaffold solubility is improved by combined bioinformatic and CamSol analysis.•Adnectins differing at a single amino acid position…”
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Ensemble Modeling and Intracellular Aggregation of an Engineered Immunoglobulin-Like Domain by Trainor, Kyle, Gingras, Zachary, Shillingford, Cicely, Malakian, Heather, Gosselin, Michael, Lipovšek, Daša, Meiering, Elizabeth M.

“…The production of recombinant proteins in Escherichia coli frequently results in the formation of insoluble protein aggregates called inclusion bodies (IBs)…”
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Using natural sequences and modularity to design common and novel protein topologies by Broom, Aron, Trainor, Kyle, MacKenzie, Duncan WS, Meiering, Elizabeth M

“…[Display omitted] •Natural sequences, structural modularity and symmetry can facilitate protein design.•Symmetry allows for tractable computational design of…”
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