Search Results - "Trainor, G L"

Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2 by Purandare, A V, McDevitt, T M, Wan, H, You, D, Penhallow, B, Han, X, Vuppugalla, R, Zhang, Y, Ruepp, S U, Trainor, G L, Lombardo, L, Pedicord, D, Gottardis, M M, Ross-Macdonald, P, de Silva, H, Hosbach, J, Emanuel, S L, Blat, Y, Fitzpatrick, E, Taylor, T L, McIntyre, K W, Michaud, E, Mulligan, C, Lee, F Y, Woolfson, A, Lasho, T L, Pardanani, A, Tefferi, A, Lorenzi, M V

“…We report the characterization of BMS-911543, a potent and selective small-molecule inhibitor of the Janus kinase (JAK) family member, JAK2. Functionally,…”
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Cyclin-Dependent Kinase Inhibitors:  Useful Targets in Cell Cycle Regulation by Sielecki, Thais M, Boylan, John F, Benfield, Pamela A, Trainor, George L

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Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1 by Corbett, J W, Ko, S S, Rodgers, J D, Jeffrey, S, Bacheler, L T, Klabe, R M, Diamond, S, Lai, C M, Rabel, S R, Saye, J A, Adams, S P, Trainor, G L, Anderson, P S, Erickson-Viitanen, S K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors by Patel, Mona, McHugh, Robert J, Cordova, Beverly C, Klabe, Ronald M, Erickson-Viitanen, Susan, Trainor, George L, Rodgers, James D

“…A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl ( 6b and 6f),…”
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Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA TM) by Patel, Mona, McHugh, Robert J., Cordova, Beverly C., Klabe, Ronald M., Erickson-Viitanen, Susan, Trainor, George L., Ko, Soo S.

“…Two series of benzoxazinones differing in the aromatic substitution pattern were prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The 5-fluoro…”
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Synthesis and evaluation of analogs of Efavirenz (SUSTIVA TM) as HIV-1 reverse transcriptase inhibitors by Patel, Mona, Ko, Soo S., McHugh, Robert J., Markwalder, Jay A., Srivastava, Anurag S., Cordova, Beverly C., Klabe, Ronald M., Erickson-Viitanen, Susan, Trainor, George L., Seitz, Steven.P.

“…Efavirenz (SUSTIVA TM) is a potent non-nucleoside reverse transcriptase inhibitor. Due to the observation of breakthrough mutations of the reverse…”
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Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones by Marcinkeviciene, Jovita, Rogers, M.John, Kopcho, Lisa, Jiang, Wenjun, Wang, Kathy, Murphy, Dennis J, Lippy, Jonathan, Link, Steven, Chung, Thomas D.Y, Hobbs, Frank, Haque, Tasir, Trainor, George L, Slee, Andrew, Stern, Andrew M, Copeland, Robert A

“…Dihydroorotate dehydrogenase is a critical enzyme of de novo pyrimidine biosynthesis in prokaryotic and eukaryotic cells. Differences in the primary structure…”
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A System for Rapid DNA Sequencing with Fluorescent Chain-Terminating Dideoxynucleotides by Prober, James M., Trainor, George L., Dam, Rudy J., Hobbs, Frank W., Robertson, Charles W., Zagursky, Robert J., Cocuzza, Anthony J., Jensen, Mark A., Baumeister, Kirk

“…A DNA sequencing system based on the use of a novel set of four chain-terminating dideoxynucleotides, each carrying a different chemically tuned…”
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Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists by Beck, James P., Arvanitis, Argyrios G., Curry, Matt A., Rescinito, Joseph T., Fitzgerald, Larry W., Gilligan, Paul J., Zaczek, Robert, Trainor, George L.

“…A series of purin-8-ones was prepared and discovered to have excellent binding affintity to the CRH-R1 receptor. Structure-activity studies focused on amine…”
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Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists by Beck, James P., Curry, Matt A., Chorvat, Robert J., Fitzgerald, Larry W., Gilligan, Paul J., Zaczek, Robert, Trainor, George L.

“…A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise…”
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Nonsymmetric P2/P2‘ Cyclic Urea HIV Protease Inhibitors. Structure−Activity Relationship, Bioavailability, and Resistance Profile of Monoindazole-Substituted P2 Analogues by De Lucca, George V, Kim, Ui T, Liang, Jing, Cordova, Beverly, Klabe, Ronald M, Garber, Sena, Bacheler, Lee T, Lam, Gilbert N, Wright, Matthew R, Logue, Kelly A, Erickson-Viitanen, Susan, Ko, Soo S, Trainor, George L

“…Using the structural information gathered from the X-ray structures of various cyclic urea/HIVPR complexes, we designed and synthesized many nonsymmetrical…”
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Inhibition of Clinically Relevant Mutant Variants of HIV-1 by Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors by Corbett, Jeffrey W, Ko, Soo S, Rodgers, James D, Gearhart, Lisa A, Magnus, Nicholas A, Bacheler, Lee T, Diamond, Sharon, Jeffrey, Susan, Klabe, Ronald M, Cordova, Beverly C, Garber, Sena, Logue, Kelly, Trainor, George L, Anderson, Paul S, Erickson-Viitanen, Susan K

“…A series of 4-alkenyl and 4-alkynyl-3,4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones were found to be potent non-nucleoside reverse transcriptase…”
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DNA recognition of base analogue and chemically modified substrates by the TaqI restriction endonuclease by ZEBALA, J. A, CHOI, J, TRAINOR, G. L, BARANY, F

“…It has been proposed that protein-DNA recognition is mediated via specific hydrogen bond, hydrophobic, and/or electrostatic interactions between the protein…”
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MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products by Duncia, John V., Santella, Joseph B., Higley, C.Anne, Pitts, William J., Wityak, John, Frietze, William E., Rankin, F.Wayne, Sun, Jung-Hui, Earl, Richard A., Tabaka, A.Christine, Teleha, Christopher A., Blom, Karl F., Favata, Margaret F., Manos, Elizabeth J., Daulerio, Andrea J., Stradley, Deborah A., Horiuchi, Kurumi, Copeland, Robert A., Scherle, Peggy A., Trzaskos, James M., Magolda, Ronald L., Trainor, George L., Wexler, Ruth R., Hobbs, Frank W., Olson, Richard E.

“…In search of antiinflammatory drugs with a new mechanism of action, U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive…”
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DNA sequencing, automation, and the human genome by Trainor, George L

“…DNA sequencing is one of the key analytical operations of modern molecular biology and a crucial element of biotechnology. The principles of DNA sequencing and…”
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Quinazolines as cyclin dependent kinase inhibitors by Sielecki, Thais M., Johnson, Tricia L., Liu, Jie, Muckelbauer, Jodi K., Grafstrom, Robert H., Cox, Sarah, Boylan, John, Burton, Catherine R., Chen, Haiying, Smallwood, Angela, Chang, Chong-Hwan, Boisclair, Michael, Benfield, Pamela A., Trainor, George L., Seitz, Steven P.

“…Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray…”
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Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase by HAQUE, Tasir S., TADESSE, Seifu, MARCINKEVICIENE, Jovita, ROGERS, M. John, SIZEMORE, Christine, KOPCHO, Lisa M., AMSLER, Karen, ECRET, Lisa D., ZHAN, Dong Liang, HOBBS, Frank, SLEE, Andrew, TRAINOR, George L., STERN, Andrew M., COPELAND, Robert A., COMBS, Andrew P.

“…The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach…”
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Synthesis and Evaluation of Efavirenz (Sustiva TM) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain by Cocuzza, Anthony J., Chidester, Dennis R., Cordova, Beverly C., Jeffrey, Susan, Parsons, Rodney L., Bacheler, Lee T., Erickson-Viitanen, Susan, Trainor, George L., Ko, Soo S.

“…Two series of efavirenz analogues have been developed: one in which the cyclopropane ring has been replaced by small heterocycles and another in which the…”
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Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate by Sands, H, Gorey-Feret, L J, Cocuzza, A J, Hobbs, F W, Chidester, D, Trainor, G L

“…Biodistribution and metabolism of oligonucleotides were determined using a 3H-labeled 20-nucleotide phosphodiester and its phosphorothioate analog. The…”
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Potent Antisense Oligonucleotides to the Human Multidrug Resistance-1 mRNA Are Rationally Selected by Mapping RNA-Accessible Sites With Oligonucleotide Libraries by Peng Ho, Siew, Britton, Dustin H. O., Stone, Barry A., Behrens, Davette L., Leffet, Lynn M., Hobbs, Frank W., Miller, Jeff A., Trainor, George L.

“…Antisense oligonucleotides can vary significantly and unpredictably in their ability to inhibit protein synthesis. Libraries of chimeric oligonucleotides and…”
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