Search Results - "Trainor, Cecelia D."

GATA1 Binding Kinetics on Conformation-Specific Binding Sites Elicit Differential Transcriptional Regulation by Hasegawa, Atsushi, Kaneko, Hiroshi, Ishihara, Daishi, Nakamura, Masahiro, Watanabe, Akira, Yamamoto, Masayuki, Trainor, Cecelia D., Shimizu, Ritsuko

“…GATA1 organizes erythroid and megakaryocytic differentiation by orchestrating the expression of multiple genes that show diversified expression profiles. Here,…”
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Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development by Planutis, Antanas, Xue, Li, Trainor, Cecelia D, Dangeti, Mohan, Gillinder, Kevin, Siatecka, Miroslawa, Nebor, Danitza, Peters, Luanne L, Perkins, Andrew C, Bieker, James J

“…Transcription factor control of cell-specific downstream targets can be significantly altered when the controlling factor is mutated. We show that the…”
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GATA-1 Self-association Controls Erythroid Development in Vivo by Shimizu, Ritsuko, Trainor, Cecelia D., Nishikawa, Keizo, Kobayashi, Makoto, Ohneda, Kinuko, Yamamoto, Masayuki

“…GATA-1 is the key transcription factor for the development of the erythroid, megakaryocytic, eosinophilic, and mast cell lineages. GATA-1 possesses the ability…”
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GATA-1 associates with and inhibits p53 by Trainor, Cecelia D., Mas, Caroline, Archambault, Patrick, Di Lello, Paola, Omichinski, James G.

“…In addition to orchestrating the expression of all erythroid-specific genes, GATA-1 controls the growth, differentiation, and survival of the erythroid lineage…”
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Transgenic rescue of GATA-1–deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia by Shimizu, Ritsuko, Ohneda, Kinuko, Engel, James Douglas, Trainor, Cecelia D., Yamamoto, Masayuki

“…Association of GATA-1 and its cofactor Friend of GATA-1 (FOG-1) is essential for erythroid and megakaryocyte development. To assess functions of GATA-1–FOG-1…”
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GATA Zinc Finger Interactions Modulate DNA Binding and Transactivation by Trainor, C D, Ghirlando, R, Simpson, M A

“…GATA-1 and other vertebrate GATA factors contain a DNA binding domain composed of two adjacent homologous zinc fingers. Whereas only the C-terminal finger of…”
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Determinants of GATA-1 binding to DNA: the role of non-finger residues by Ghirlando, Rodolfo, Trainor, Cecelia D

“…Mammalian GATA transcription factors are expressed in various tissues in a temporally regulated manner. The prototypic member, GATA-1, is required for normal…”
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Interleukin-13 gene expression is regulated by GATA-3 in T cells: role of a critical association of a GATA and two GATG motifs by Lavenu-Bombled, Cecile, Trainor, Cecelia D, Makeh, Iman, Romeo, Paul-Henri, Max-Audit, Isabelle

“…Using a transgenic approach, we studied the role of GATA-3 in T cells. As previously shown, enforced GATA-3 expression in transgenic mice inhibits Th1…”
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Determinants of GATA-1 Binding to DNA by Ghirlando, Rodolfo, Trainor, Cecelia D.

“…Mammalian GATA transcription factors are expressed in various tissues in a temporally regulated manner. The prototypic member, GATA-1, is required for normal…”
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A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction by Trainor, Cecelia D., Omichinski, James G., Vandergon, Thomas L., Gronenborn, Angela M., Clore, G. Marius, Felsenfeld, Gary

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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LCR-regulated transgene expression levels depend on the Oct-1 site in the AT-rich region of β-globin intron-2 by Bharadwaj, Rikki R., Trainor, Cecelia D., Pasceri, Peter, Ellis, James

“…Human β-globin transgenes regulated by the locus control region (LCR) express at all integration sites in transgenic mice. For such LCR activity at ectopic…”
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GATA-1 Bends DNA in a Site-independent Fashion by Ghirlando, R, Trainor, C D

“…The DNA binding domain of GATA-1 consists of two adjacent homologous zinc fingers, of which only the C-terminal finger binds DNA independently. Solution…”
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Erythroid-specific transcription of the chicken histone H5 gene is directed by a 3' enhancer by Trainor, Cecelia D, Stamler, Susan J, Engel, James Douglas

“…The expression of a variety of vertebrate genes is transcriptionally regulated through tissue-specific cellular enhancer elements. An erythroid-specific…”
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Interleukin-13 Gene Expression Is Regulated by GATA-3 in T Cells by Lavenu-Bombled, Cecile, Trainor, Cecelia D., Makeh, Iman, Romeo, Paul-Henri, Max-Audit, Isabelle

“…Using a transgenic approach, we studied the role of GATA-3 in T cells. As previously shown, enforced GATA-3 expression in transgenic mice inhibits Th1…”
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Structure and evolution of a human erythroid transcription factor by Trainor, Cecelia D, Evans, Todd, Felsenfeld, Gary, Boguski, Mark S

“…Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding…”
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GATA1 Changes DNA-Binding Fashion in a Binding-Site-Specific Manner and Alters Transcriptional Activity during Erythropoiesis by Hasegawa, Atsushi, Kaneko, Hiroshi, Ishihara, Daishi, Nakamura, Masahiro, Watanabe, Akira, Trainor, Cecelia D, Masayuki, Yamamoto, Shimizu, Ritsuko

“…GATA1 is a transcription factor that coordinately regulates multiple target genes during the development and differentiation of erythroid and megakaryocytic…”
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Recombinant Erythroid Kruppel-Like Factor Fused to GATA1 up-Regulates δ-Globin Expression In Erythroid Cells by Zhu, Jianqiongz, Chin, Kyung, Aerbajinai, Wulin, Trainor, Cecelia D, Perter, Gao, Rodgers, Griffin P.

“…Abstract 3752 The β-hemoglobinopathies sickle cell disease and β-thalassemia are among the most common human genetic disorders worldwide. Hemoglobin A2 (HbA2,…”
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Negative regulation of chicken GATA-1 promoter activity mediated by a hormone response element by Trainor, C D, Evans, T, Felsenfeld, G

“…GATA-1 is a DNA-binding protein that regulates transcription of erythroid-specific genes and is required for the formation of mature erythroid cells. We show…”
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Transcription of the Chicken Histone H5 Gene Is Mediated by Distinct Tissue-Specific Elements within the Promoter and the 3′ Enhancer by Trainor, Cecelia D., Engel, James Douglas

“…Molecular genetic analysis of a number of vertebrate erythroid cell-specific genes has identified at least two types of cis-acting regulatory sequences which…”
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Methylation of human T-cell leukemia virus proviral DNA and viral RNA expression in short- and long-term cultures of infected cells by Clarke, M F, Trainor, C D, Mann, D L, Gallo, R C, Reitz, M S

“…Leukemic peripheral blood lymphocytes from individuals infected with the human T-cell leukemia/lymphoma virus (HTLV) were found to express little or no viral…”
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