Search Results - "Trager, W.F."

Isotopically labeled chlorobenzenes as probes for the mechanism of cytochrome P-450 catalyzed aromatic hydroxylation by Korzekwa, K R, Swinney, D C, Trager, W F

“…Noncompetitive and competitive intermolecular deuterium isotope effects were measured for the cytochrome P-450 catalyzed hydroxylation of a series of…”
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Topiramate and Phenytoin Pharmacokinetics During Repetitive Monotherapy and Combination Therapy to Epileptic Patients by Sachdeo, Rajesh C., Sachdeo, S.K., Levy, R.H., Streeter, A.J., Bishop, F.E., Kunze, K.L., Mather, G.G., Roskos, L.K., Shen, D.D., Thummel, K.E., Trager, W.F., Curtin, C. R., Doose, Dennis R., Gisclon, L.G., Bialer, Meir

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Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: a new method for the estimation of intrinsic isotope effects by Jones, Jeffrey P, Korzekwa, Kenneth R, Rettie, Allan E, Trager, William F

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Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: cytochrome P-450 by KORZEKWA, K. R, TRAGER, W. F, GILLETTE, J. R

“…By use of cytochrome P-450 as the prototype, kinetic descriptions are derived for the observed isotope effects for several models of enzymatic systems which…”
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Intrinsic isotope effects suggest that the reaction coordinate symmetry for the cytochrome P-450-catalyzed hydroxylation of octane is isozyme independent by Jones, Jeffrey P, Rettie, Allan E, Trager, William F

“…The mechanism of the omega-hydroxylation of octane by three catalytically distinct, purified forms of cytochrome P-450, namely, P-450b, P-450c, and P-450LM2,…”
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The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components by Jones, Jefferey P, Trager, William F

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Prochiral selectivity and intramolecular isotope effects in the cytochrome P-450 catalyzed .omega.-hydroxylation of cumene by Sugiyama, Katsumi, Trager, William F

“…A kinetic model is presented from which steady-state equations are derived that describe the intramolecular competition for the enzymatically mediated…”
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Intramolecular isotope effects associated with meta-hydroxylation of biphenyl catalyzed by cytochrome P-450 by Swinney, D C, Howald, W N, Trager, W F

“…Intramolecular isotope effects and the degree of deuterium retention were determined for the meta-hydroxylation of biphenyl as catalyzed by microsomal…”
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Quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling by Nelson, S D, Garland, W A, Breck, G D, Trager, W F

“…Quantification of the suspected metabolites of lidocaine in humans was carried out using the direct insertion probe and chemicalionization mass spectrometry…”
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Primary and .beta.-secondary deuterium isotope effects in N-deethylation reactions by Nelson, Sidney D, Pohl, Lance R, Trager, William F

“…Lidocaine (1), labeled specifically with deuterium in the alpha-methylene (lidocaine-d4,2) and beta-methyl (lidocaine-d6,3) carbon atoms of the terminal amino…”
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Corynantheidine-type alkaloids. II. Absolute configuration of mitragynine, speciociliatine, mitraciliatine and speciogynine by Lee, C M, Trager, W F, Beckett, A H

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Corynantheidine-type alkaloids. I. Establishment of physical criteria for the normal, pseudo, allo and epiallo configurations by conformational analysis by Trager, W F, Lee, C M, Beckett, A H

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Application of negative-ion chemical ionization isotope dilution gas chromatography--mass spectrometry to single-dose bioavailability studies of mefloquine by Neal, J M, Howald, W N, Kunze, K L, Lawrence, R F, Trager, W F

“…An electron-capture negative-ion chemical ionization gas chromatographic-mass spectrometric assay for mefloquine, an antimalarial drug used in the treatment of…”
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Warfarin: stereochemical aspects of its metabolism in vivo in the rat by Pohl, L R, Bales, R, Trager, W F

“…The biotransformation of the R and S isomers of warfarin was investigated in the rat. The formation of 7-hydroxywarfarin was stereoselective for the R…”
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Configurational analysis of rhynchophylline-type oxindole alkaloids. The absolute configuration of ciliaphylline, rhynchociline, specionoxeine, isospecionoxeine, rotundifoline and isorotundifoline by Trager, W F, Lee, C M, Phillipson, J D, Haddock, R E, Dwuma-Badu, D, Beckett, A H

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Chemical confirmation for the configurations assigned to the indole alkaloids, speciogynine, speciociliatine, mitraciliatine and hirsutine by Trager, W F, Phillipson, J D, Beckett, A H

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