Search Results - "Trafford, A.W."

Differences in intracellular calcium homeostasis between atrial and ventricular myocytes by Walden, A.P, Dibb, K.M, Trafford, A.W

“…Abstract The role that Ca2+ plays in ventricular excitation contraction coupling is well defined and much is known about the marked differences in the…”
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What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? by Eisner, D.A, Kashimura, T, O'Neill, S.C, Venetucci, L.A, Trafford, A.W

“…Abstract In this article we review the role of the Ryanodine Receptor (RyR) in cardiac inotropy and arrhythmogenesis. Most of the calcium that activates…”
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Reducing Ryanodine Receptor Open Probability as a Means to Abolish Spontaneous Ca2+ Release and Increase Ca2+ Transient Amplitude in Adult Ventricular Myocytes by Venetucci, L A, Trafford, A W, Díaz, M E, O’Neill, S C, Eisner, D A

“…The aim of this work was to investigate whether it is possible to remove arrhythmogenic Ca release from the sarcoplasmic reticulum that occurs in calcium…”
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Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart by Dibb, K.M, Graham, H.K, Venetucci, L.A, Eisner, D.A, Trafford, A.W

“…Abstract Central to controlling intracellular calcium concentration ([Ca2+ ] i ) are a number of Ca2+ transporters and channels with the L-type Ca2+ channel,…”
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The control of sarcoplasmic reticulum Ca content in cardiac muscle by Díaz, M.E., Graham, H.K., O’Neill, S.C., Trafford, A.W., Eisner, D.A.

“…Most of the calcium that activates contraction in the heart comes from the sarcoplasmic reticulum (SR) and it is therefore essential to control the SR Ca…”
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Increased ICaL Underlies Ventricular Action-Potential Prolongation After Spontaneous Ca2+ Release From The Sarcoplasmic Reticulum by Johnson, D.M, Heijman, J, Bode, E.F, Greensmith, D.J, Abi-Gerges, N, Eisner, D.A, Trafford, A.W, Volders, P.G.A

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The control of Ca release from the cardiac sarcoplasmic reticulum : regulation versus autoregulation by EISNER, D. A, TRAFFORD, A. W, DIAZ, M. E, OVEREND, C. L, O'NEILL, S. C

“…This review discusses the mechanism and regulation of Ca release from the cardiac sarcoplasmic reticulum. Ca is released through the Ca release channel or…”
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Life, Sudden Death, and Intracellular Calcium by Eisner, D A, Venetucci, L A, Trafford, A W

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Measurement of sarcoplasmic reticulum Ca2+ content and sarcolemmal Ca2+ fluxes in isolated rat ventricular myocytes during spontaneous Ca2+ release by Díaz, M E, Trafford, A W, O'Neill, S C, Eisner, D A

“…1. Intracellular calcium concentration ([Ca2+]i) and Na(+)-Ca2+ exchange currents were measured in calcium-overloaded voltage-clamped rat ventricular myocytes…”
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The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes by Trafford, A.W., Sibbring, G.C., Díaz, M.E., Eisner, D.A.

“…We have investigated the effects on spontaneous SR Ca release of modulating the sarcoplasmic reticulum ryanodine receptor (RyR) with low (<0.5mM)…”
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Heart Failure and the Ryanodine Receptor: Does Occam’s Razor Rule? by Eisner, D A, Trafford, A W

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The Effects of Exogenous Calcium Buffers on the Systolic Calcium Transient in Rat Ventricular Myocytes by Díaz, M.E., Trafford, A.W., Eisner, D.A.

“…The aim of this work was to characterize the effects that two commonly used “caged” calcium buffers (NP-EGTA and nitr-5) have on the amplitude and time course…”
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Illuminating Sarcoplasmic Reticulum Calcium by Venetucci, L, Trafford, A W, Eisner, D A

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Age-related changes in the micromechanical properties of ovine aorta by Akhtar, R, Kridiotis, C, Graham, H.K, Sherratt, M.J, Trafford, A.W, Cruickshank, J.K, Derby, B

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The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes by Díaz, M E, Trafford, A W, Eisner, D A

“…We have studied the kinetics of decay of cardiac Ca transients elicited by either caffeine or electrical stimulation. The decay of the caffeine-evoked increase…”
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5.3 Age-Related Changes in the Micromechanical Properties of Ovine Aorta by Akhtar, R., Kridiotis, C., Graham, H. K., Sherratt, M. J., Trafford, A. W., Cruickshank, J. K., Derby, B.

“…Scanning Acoustic Microscopy (SAM) images have a spatial resolution at 1 GHz comparable to conventional optical microscopy. Each pixel in the image can be…”
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Phosphodiesterase-5 inhibition with sildenafil suppresses triggered ventricular arrhythmias and calcium waves via reduced sarcoplasmic reticulum content in the large mammal by Hutchings, D.C., Pearman, C., Madders, G., Woods, L., Dibb, K., Eisner, D., Trafford, A.W.

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Susceptibility to atrial alternans; a role for transverse (t)-tubule loss in heart failure (HF)? by Madders, G.W.P., Woods, L., Hutchings, D.C., Waddell, C.A., Denham, N., Trafford, A.W., Eisner, D.A., Dibb, K.M.

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Nanoindentation of histological specimens: Mapping the elastic properties of soft tissues by Akhtar, R., Schwarzer, N., Sherratt, M.J., Watson, R.E.B., Graham, H.K., Trafford, A.W., Mummery, P.M., Derby, B.

“…Although alterations in the gross mechanical properties of dynamic and compliant tissues have a major impact on human health and morbidity, there are no…”
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Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta by Akhtar, R., Graham, H.K., Derby, B., Sherratt, M.J, Trafford, A.W., Chadwick, R.S., Gavara, N.

“…Age-related aortic stiffening is associated with cardiovascular diseases such as heart failure. The mechanical functions of the main structural components of…”
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