Search Results - "Traffic (Copenhagen, Denmark)"
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Lysosomal membrane permeabilization and cell death
Published in Traffic (Copenhagen, Denmark) (01-12-2018)“…Lysosomes are membrane‐enclosed organelles that mediate the intracellular degradation of macromolecules. They play an essential role in calcium regulation and…”
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The role of lipids in exosome biology and intercellular communication: Function, analytics and applications
Published in Traffic (Copenhagen, Denmark) (01-07-2021)“…Exosomes are extracellular vesicles that in recent years have received special attention for their regulatory functions in numerous biological processes…”
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Phospholipid Synthesis and Transport in Mammalian Cells
Published in Traffic (Copenhagen, Denmark) (01-01-2015)“…This article summarizes the pathways and sites of biosynthesis of the major mammalian phospholipids. Mechanisms proposed for the inter‐organelle transport of…”
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Fusion of Enveloped Viruses in Endosomes
Published in Traffic (Copenhagen, Denmark) (01-06-2016)“…To initiate infection, enveloped viruses must fuse with a cell membrane, a process mediated by a dedicated viral fusion protein. To date, these proteins group…”
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Mechanisms of lysosomal positioning and movement
Published in Traffic (Copenhagen, Denmark) (01-10-2018)“…Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They distribute in a rather immobile pool located around the…”
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Life in the lumen: The multivesicular endosome
Published in Traffic (Copenhagen, Denmark) (01-01-2020)“…The late endosomes/endo‐lysosomes of vertebrates contain an atypical phospholipid, lysobisphosphatidic acid (LBPA) (also termed bis[monoacylglycero]phosphate…”
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The road to lysosome‐related organelles: Insights from Hermansky‐Pudlak syndrome and other rare diseases
Published in Traffic (Copenhagen, Denmark) (01-06-2019)“…Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific, membrane‐bound subcellular organelles that derive at least in part from the…”
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The biology of extracellular microvesicles
Published in Traffic (Copenhagen, Denmark) (01-05-2018)“…The study of extracellular vesicles (EVs) is a rapidly evolving field, owing in large part to recent advances in the realization of their significant…”
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Lysosomal size matters
Published in Traffic (Copenhagen, Denmark) (01-01-2020)“…Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and…”
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Towards a molecular understanding of endosomal trafficking by Retromer and Retriever
Published in Traffic (Copenhagen, Denmark) (01-07-2019)“…Endosomes are dynamic intracellular compartments that control the sorting of a constant stream of different transmembrane cargos either for ESCRT‐mediated…”
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Exosomes: Revisiting their role as “garbage bags”
Published in Traffic (Copenhagen, Denmark) (01-11-2019)“…In recent years, the term “extracellular vesicle” (EV) has been used to define different types of vesicles released by various cells. It includes plasma…”
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Forty Years of Clathrin‐coated Vesicles
Published in Traffic (Copenhagen, Denmark) (01-12-2015)“…Forty years ago, Barbara Pearse purified coated vesicles from pig brain and discovered the protein clathrin. This review highlights some of the key discoveries…”
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Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses
Published in Traffic (Copenhagen, Denmark) (01-12-2011)“…Exosomes are small membrane vesicles, secreted by most cell types from multivesicular endosomes, and thought to play important roles in intercellular…”
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Endosomal receptor trafficking: Retromer and beyond
Published in Traffic (Copenhagen, Denmark) (01-08-2018)“…The tubular endolysosomal network is a quality control system that ensures the proper delivery of internalized receptors to specific subcellular destinations…”
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Lysosome: The metabolic signaling hub
Published in Traffic (Copenhagen, Denmark) (01-01-2019)“…For the past five decades, the lysosome has been characterized as an unglamorous cellular recycling center. This notion has undergone a radical shift in the…”
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Defining raft domains in the plasma membrane
Published in Traffic (Copenhagen, Denmark) (01-01-2020)“…Many plasma membrane (PM) functions depend on the cholesterol concentration in the PM in strikingly nonlinear, cooperative ways: fully functional in the…”
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COPII‐mediated trafficking at the ER/ERGIC interface
Published in Traffic (Copenhagen, Denmark) (01-07-2019)“…Coat proteins play multiple roles in the life cycle of a membrane‐bound transport intermediate, functioning in lipid bilayer remodeling, cargo selection and…”
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Transcellular vesicular transport in epithelial and endothelial cells: Challenges and opportunities
Published in Traffic (Copenhagen, Denmark) (01-01-2018)“…Vesicle‐mediated transcellular transport or simply “transcytosis” is a cellular process used to shuttle macromolecules such as lipoproteins, antibodies, and…”
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SNARE proteins in membrane trafficking
Published in Traffic (Copenhagen, Denmark) (01-12-2017)“…SNAREs are the core machinery mediating membrane fusion. In this review, we provide an update on the recent progress on SNAREs regulating membrane fusion…”
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Role of Flippases, Scramblases and Transfer Proteins in Phosphatidylserine Subcellular Distribution
Published in Traffic (Copenhagen, Denmark) (01-01-2015)“…The eukaryotic plasma membrane (PM) and internal organelles have unique lipid compositions. However, the mechanisms by which specific lipid species are…”
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