Search Results - "Trader, M W"

Evaluation of trans-tetrachloro-1,2-diaminocyclohexane platinum(IV) in murine leukemia L1210 resistant and sensitive to cis-diamminedichloroplatinum(II) by WILKOFF, L. J, DULMADGE, E. A, TRADER, M. W, HARRISON, S. D. JR, GRISWOLD, D. P. JR

“…trans-Tetrachloro-1,2-diaminocyclohexane platinum (IV) (tetraplatin) was therapeutically effective in mice bearing leukemia L1210 resistant (L1210/DDPt) or…”
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Preclinical antitumor activity and pharmacological properties of deoxyspergualin by PLOWMAN, J, HARRISON, S. D. JR, TRADER, M. W, GRISWOLD, D. P. JR, CHADWICK, M, MCCOMISH, M. F, SILVEIRA, D. M, ZAHARKO, D

“…A new antibiotic, deoxyspergualin (DSG), demonstrated antitumor activity against L1210 leukemia in mice. The life span of mice bearing either i.p. or…”
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Therapeutic activity of mitoxantrone and ametantrone against murine tumors by Schabel, Jr, F M, Corbett, T H, Griswold, Jr, D P, Laster, Jr, W R, Trader, M W

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Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide by Struck, R F, Dykes, D J, Corbett, T H, Suling, W J, Trader, M W

“…Isophosphoramide mustard was synthesized and was found to demonstrate activity essentially comparable to cyclophosphamide and ifosfamide against L1210 and P388…”
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Therapeutic synergism of tiazofurin and selected antitumor drugs against sensitive and resistant P388 leukemia in mice by HARRISON, S. D. JR, O'DWYER, P. J, TRADER, M. W

“…Tiazofurin is a synthetic "C" nucleoside analogue with a promising spectrum of experimental antitumor activity and a relatively novel mechanism of action…”
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cis-Dichlorodiammineplatinum(II): combination chemotherapy and cross-resistance studies with tumors of mice by Schabel, Jr, F M, Trader, M W, Laster, Jr, W R, Corbett, T H, Griswold, Jr, D P

“…cis-Dichlorodiammineplatinum(II) (cis-platinum) has no more than additive, and often much less than additive, lethal toxicity for mice when given in…”
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The preclinical scientific basis for adjuvant chemotherapy in breast cancer by Griswold, Jr, D P, Laster, Jr, W R, Trader, M W, Dykes, D J

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Establishment of cross-resistance profiles for new agents by Schabel, Jr, F M, Skipper, H E, Trader, M W, Laster, Jr, W R, Griswold, Jr, D P, Corbett, T H

“…Sublines of murine leukemias (L1210 and P388) and solid tumors selected for resistance to representatives of all of the chemical and functional classes of…”
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Response of drug-sensitive and -resistant L1210 leukemias to high-dose chemotherapy by GRISWOLD, D. P. JR, TRADER, M. W, FREI, E. III, PETERS, W. P, WOLPERT, M. K, LASTER, W. R. JR

“…Alkylating agent-sensitive and -resistant L1210 leukemia cell lines were used to determine the tumor response to dose levels of drugs that exceeded…”
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Response of transplantable tumors of mice to anthracenedione derivatives alone and in combination with clinically useful agents by Corbett, T H, Roberts, B J, Trader, M W, Laster, Jr, W R, Griswold, Jr, D P, Schabel, Jr, F M

“…Other investigators have demonstrated that dihydroxyanthracenedione (DiOHA) and anthracenedione acetate (AA) are active against a broad spectrum of…”
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Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors by Rose, W C, Trader, M W, Dykes, D J, Laster, Jr, W R, Schabel, Jr, F M

“…The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210…”
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Chronochemotherapy of L1210 leukemic mice with cytosine arabinoside or cyclophosphamide by Rose, W C, Trader, M W, Laster, Jr, W R, Schabel, Jr, F M

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Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model-end of 1971 by Skipper, H E, Schabel, Jr, F M, Trader, M W, Laster, Jr, W R, Simpson-Herren, L, Lloyd, H H

“…Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model have been brought together for comparison with available…”
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Spontaneous AK leukemia (lymphoma) as a model system by Schabel, Jr, F M, Skipper, H E, Trader, M W, Laster, Jr, W R, Simpson-Herren, L

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Response to therapy of spontaneous, first passage, and long passage lines of AK leukemia by Skipper, H E, Schabel, Jr, F M, Trader, M W, Laster, Jr, W R

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Drug control of Ara-C-resistant tumor cells by Schabel, Jr, F M, Skipper, H E, Trader, M W, Brockman, R W, Laster, Jr, W R, Corbett, T H, Griswold, Jr, D P

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Patterns of resistance and therapeutic synergism among alkylating agents by Schabel, Jr, F M, Trader, M W, Laster, Jr, W R, Wheeler, G P, Witt, M H

“…Alkylating anticancer drugs are varied in chemical structure, alkylating moieties, and likely mechanisms of cytotoxic activity for vital normal cells and…”
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Synergistic antileukemic activity of combinations of two nitrosoureas by Wheeler, G P, Schabel, Jr, F M, Trader, M W

“…A rationale based on known chemical, biochemical, and biologic properties of nitrosoureas led to the testing of combinations of CCNU with chlorozotocin for in…”
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Some biochemical characteristics of L1210 cell lines resistant to 6-mercaptopurine and 6-thioguanine and with increased sensitivity to methotrexate by Strobel-Stevens, J D, El Dareer, S M, Trader, M W, Hill, D L

“…L1210 cells resistant to 6MP and 6TG exhibit increased sensitivity to MTX compared to the parent line. The differential response of parent and purine…”
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Experimental evaluation of potential anticancer agents. XIX. Sensitivity of nondividing leukemic cell populations to certain classes of drugs in vivo by Schabel, Jr, F M, Skipper, H E, Trader, M W, Wilcox, W S

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