Search Results - "Tracy, Tara E."

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss by Tracy, Tara E., Sohn, Peter Dongmin, Minami, S. Sakura, Wang, Chao, Min, Sang-Won, Li, Yaqiao, Zhou, Yungui, Le, David, Lo, Iris, Ponnusamy, Ravikumar, Cong, Xin, Schilling, Birgit, Ellerby, Lisa M., Huganir, Richard L., Gan, Li

“…Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer’s disease (AD), but the mechanism by which tau alters synapse physiology…”
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Astrocyte senescence promotes glutamate toxicity in cortical neurons by Limbad, Chandani, Oron, Tal Ronnen, Alimirah, Fatouma, Davalos, Albert R, Tracy, Tara E, Gan, Li, Desprez, Pierre-Yves, Campisi, Judith

“…Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of patients with Alzheimer's and related dementias and cancer patients…”
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Amyloid beta emerges from below the neck to disable the brain by Kauwe, Grant, Tracy, Tara E

“…Accumulation of amyloid beta (Aβ) in the brain in Alzheimer disease drives pathophysiology. A study in this issue of PLOS Biology revealed that Aβ from the…”
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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits by Min, Sang-Won, Chen, Xu, Tracy, Tara E, Li, Yaqiao, Zhou, Yungui, Wang, Chao, Shirakawa, Kotaro, Minami, S Sakura, Defensor, Erwin, Mok, Sue Ann, Sohn, Peter Dongmin, Schilling, Birgit, Cong, Xin, Ellerby, Lisa, Gibson, Bradford W, Johnson, Jeffrey, Krogan, Nevan, Shamloo, Mehrdad, Gestwicki, Jason, Masliah, Eliezer, Verdin, Eric, Gan, Li

“…Acetylation of tau at K174 is identified in Alzheimer's disease (AD) brain tissue and exacerbates tau-mediated neurodegeneration and memory impairments in…”
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Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening by Wang, Chao, Ward, Michael E., Chen, Robert, Liu, Kai, Tracy, Tara E., Chen, Xu, Xie, Min, Sohn, Peter Dongmin, Ludwig, Connor, Meyer-Franke, Anke, Karch, Celeste M., Ding, Sheng, Gan, Li

“…Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and other tauopathies. High-throughput screening in neurons derived…”
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Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis by Sohn, Peter Dongmin, Huang, Cindy Tzu-Ling, Yan, Rui, Fan, Li, Tracy, Tara E., Camargo, Carolina M., Montgomery, Kelly M., Arhar, Taylor, Mok, Sue-Ann, Freilich, Rebecca, Baik, Justin, He, Manni, Gong, Shiaoching, Roberson, Erik D., Karch, Celeste M., Gestwicki, Jason E., Xu, Ke, Kosik, Kenneth S., Gan, Li

“…Dysregulation of neuronal excitability underlies the pathogenesis of tauopathies, including frontotemporal dementia (FTD) with tau inclusions. A majority of…”
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Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease by Tracy, Tara E, Gan, Li

“…•Soluble tau oligomers promote pathophysiology in neurons.•Pathogenic tau affects mechanisms that regulate both presynaptic and postsynaptic…”
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Acute knockdown of AMPA receptors reveals a trans-synaptic signal for presynaptic maturation by Tracy, Tara E, Yan, Jenny J, Chen, Lu

“…Newly formed glutamatergic synapses often lack postsynaptic AMPA‐type glutamate receptors (AMPARs). Aside from ‘unsilencing’ the postsynaptic site, however,…”
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Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy by Tracy, Tara E, Gan, Li

“…Pathogenesis in tauopathies involves the accumulation of tau in the brain and progressive synapse loss accompanied by cognitive decline. Pathological tau is…”
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Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration by Tracy, Tara E., Madero-Pérez, Jesus, Swaney, Danielle L., Chang, Timothy S., Moritz, Michelle, Konrad, Csaba, Ward, Michael E., Stevenson, Erica, Hüttenhain, Ruth, Kauwe, Grant, Mercedes, Maria, Sweetland-Martin, Lauren, Chen, Xu, Mok, Sue-Ann, Wong, Man Ying, Telpoukhovskaia, Maria, Min, Sang-Won, Wang, Chao, Sohn, Peter Dongmin, Martin, Jordie, Zhou, Yungui, Luo, Wenjie, Trojanowski, John Q., Lee, Virginia M.Y., Gong, Shiaoching, Manfredi, Giovanni, Coppola, Giovanni, Krogan, Nevan J., Geschwind, Daniel H., Gan, Li

“…Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. To dissect the underlying mechanisms, we combined an engineered…”
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Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience by Udeochu, Joe C., Amin, Sadaf, Huang, Yige, Fan, Li, Torres, Eileen Ruth S., Carling, Gillian K., Liu, Bangyan, McGurran, Hugo, Coronas-Samano, Guillermo, Kauwe, Grant, Mousa, Gergey Alzaem, Wong, Man Ying, Ye, Pearly, Nagiri, Ravi Kumar, Lo, Iris, Holtzman, Julia, Corona, Carlo, Yarahmady, Allan, Gill, Michael T., Raju, Ravikiran M., Mok, Sue-Ann, Gong, Shiaoching, Luo, Wenjie, Zhao, Mingrui, Tracy, Tara E., Ratan, Rajiv R., Tsai, Li-Huei, Sinha, Subhash C., Gan, Li

“…Pathological hallmarks of Alzheimer’s disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of…”
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Reducing acetylated tau is neuroprotective in brain injury by Shin, Min-Kyoo, Vázquez-Rosa, Edwin, Koh, Yeojung, Dhar, Matasha, Chaubey, Kalyani, Cintrón-Pérez, Coral J., Barker, Sarah, Miller, Emiko, Franke, Kathryn, Noterman, Maria F., Seth, Divya, Allen, Rachael S., Motz, Cara T., Rao, Sriganesh Ramachandra, Skelton, Lara A., Pardue, Machelle T., Fliesler, Steven J., Wang, Chao, Tracy, Tara E., Gan, Li, Liebl, Daniel J., Savarraj, Jude P.J., Torres, Glenda L., Ahnstedt, Hilda, McCullough, Louise D., Kitagawa, Ryan S., Choi, H. Alex, Zhang, Pengyue, Hou, Yuan, Chiang, Chien-Wei, Li, Lang, Ortiz, Francisco, Kilgore, Jessica A., Williams, Noelle S., Whitehair, Victoria C., Gefen, Tamar, Flanagan, Margaret E., Stamler, Jonathan S., Jain, Mukesh K., Kraus, Allison, Cheng, Feixiong, Reynolds, James D., Pieper, Andrew A.

“…Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for Alzheimer’s disease (AD). We report here that TBI induces tau…”
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AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation by Sayed, Faten A, Kodama, Lay, Fan, Li, Carling, Gillian K, Udeochu, Joe C, Le, David, Li, Qingyun, Zhou, Lu, Wong, Man Ying, Horowitz, Rose, Ye, Pearly, Mathys, Hansruedi, Wang, Minghui, Niu, Xiang, Mazutis, Linas, Jiang, Xueqiao, Wang, Xueting, Gao, Fuying, Brendel, Matthew, Telpoukhovskaia, Maria, Tracy, Tara E, Frost, Georgia, Zhou, Yungui, Li, Yaqiao, Qiu, Yue, Cheng, Zuolin, Yu, Guoqiang, Hardy, John, Coppola, Giovanni, Wang, Fei, DeTure, Michael A, Zhang, Bin, Xie, Lei, Trajnowski, John Q, Lee, Virginia M Y, Gong, Shiaoching, Sinha, Subhash C, Dickson, Dennis W, Luo, Wenjie, Gan, Li

“…The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 ( ), a microglia-specific gene in the brain, increases risk for late-onset…”
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Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss by Tracy, Tara E., Gan, Li

“…Pathogenesis in tauopathies involves the accumulation of tau in the brain and progressive synapse loss accompanied by cognitive decline. Pathological tau is…”
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Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment by Sohn, Peter Dongmin, Tracy, Tara E, Son, Hye-In, Zhou, Yungui, Leite, Renata E P, Miller, Bruce L, Seeley, William W, Grinberg, Lea T, Gan, Li

“…Neurons are highly polarized cells in which asymmetric axonal-dendritic distribution of proteins is crucial for neuronal function. Loss of polarized…”
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KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss by Kauwe, Grant, Pareja-Navarro, Kristeen A, Yao, Lei, Chen, Jackson H, Wong, Ivy, Saloner, Rowan, Cifuentes, Helen, Nana, Alissa L, Shah, Samah, Li, Yaqiao, Le, David, Spina, Salvatore, Grinberg, Lea T, Seeley, William W, Kramer, Joel H, Sacktor, Todd C, Schilling, Birgit, Gan, Li, Casaletto, Kaitlin B, Tracy, Tara E

“…Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer's disease (AD) and…”
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Effect of KIBRA on tau‐mediated synaptic and memory deficits by Kauwe, Grant, Pareja‐Navarro, Kristeen, Chen, Jackson, Li, Yaqiao, Le, David, Zhou, Yungui, Gan, Li, Tracy, Tara E

“…Background Alzheimer’s disease (AD) is characterized by an accumulation of tau in the brain and progressive memory decline. Previous work showed that aberrant…”
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Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer’s Disease by Martinez-Losa, Magdalena, Tracy, Tara E., Ma, Keran, Verret, Laure, Clemente-Perez, Alexandra, Khan, Abdullah S., Cobos, Inma, Ho, Kaitlyn, Gan, Li, Mucke, Lennart, Alvarez-Dolado, Manuel, Palop, Jorge J.

“…Inhibitory interneurons regulate the oscillatory rhythms and network synchrony that are required for cognitive functions and disrupted in Alzheimer’s disease…”
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Acute knockdown of AMPA receptors reveals a trans-synaptic signal for presynaptic maturation: AMPA receptor modulates presynaptic maturation by Tracy, Tara E, Yan, Jenny J, Chen, Lu

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