Search Results - "Trachtenberg, Joshua T."

Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits by Peñagarikano, Olga, Abrahams, Brett S., Herman, Edward I., Winden, Kellen D., Gdalyahu, Amos, Dong, Hongmei, Sonnenblick, Lisa I., Gruver, Robin, Almajano, Joel, Bragin, Anatol, Golshani, Peyman, Trachtenberg, Joshua T., Peles, Elior, Geschwind, Daniel H.

“…Although many genes predisposing to autism spectrum disorders (ASD) have been identified, the biological mechanism(s) remain unclear. Mouse models based on…”
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A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex by Kuhlman, Sandra J., Olivas, Nicholas D., Tring, Elaine, Ikrar, Taruna, Xu, Xiangmin, Trachtenberg, Joshua T.

“…The role of parvalbumin (PV)-positive interneurons in ocular dominance plasticity (ODP) has been a point of contention; here PV-positive cells are shown to…”
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Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory by Frank, Adam C., Huang, Shan, Zhou, Miou, Gdalyahu, Amos, Kastellakis, George, Silva, Tawnie K., Lu, Elaine, Wen, Ximiao, Poirazi, Panayiota, Trachtenberg, Joshua T., Silva, Alcino J.

“…Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient mechanism of information storage in cortical circuits…”
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The Development of Receptive Field Tuning Properties in Mouse Binocular Primary Visual Cortex by Tan, Liming, Ringach, Dario L, Trachtenberg, Joshua T

“…The mouse primary visual cortex is a model system for understanding the relationship between cortical structure, function, and behavior (Seabrook et al., 2017;…”
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Enhanced Spatial Resolution During Locomotion and Heightened Attention in Mouse Primary Visual Cortex by Mineault, Patrick J, Tring, Elaine, Trachtenberg, Joshua T, Ringach, Dario L

“…We do not fully understand how behavioral state modulates the processing and transmission of sensory signals. Here, we studied the cortical representation of…”
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Encoding and storage of spatial information in the retrosplenial cortex by Czajkowski, Rafał, Jayaprakash, Balaji, Wiltgen, Brian, Rogerson, Thomas, Guzman-Karlsson, Mikael C., Barth, Alison L., Trachtenberg, Joshua T., Silva, Alcino J.

“…The retrosplenial cortex (RSC) is part of a network of interconnected cortical, hippocampal, and thalamic structures harboring spatially modulated neurons. The…”
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Vision Changes the Cellular Composition of Binocular Circuitry during the Critical Period by Tan, Liming, Tring, Elaine, Ringach, Dario L., Zipursky, S. Lawrence, Trachtenberg, Joshua T.

“…High acuity stereopsis emerges during an early postnatal critical period when binocular neurons in the primary visual cortex sharpen their receptive field…”
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The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study by Gdalyahu, Amos, Lazaro, Maria, Penagarikano, Olga, Golshani, Peyman, Trachtenberg, Joshua T, Geschwind, Daniel H, Gescwind, Daniel H

“…The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated…”
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Associative Fear Learning Enhances Sparse Network Coding in Primary Sensory Cortex by Gdalyahu, Amos, Tring, Elaine, Polack, Pierre-Olivier, Gruver, Robin, Golshani, Peyman, Fanselow, Michael S., Silva, Alcino J., Trachtenberg, Joshua T.

“…Several models of associative learning predict that stimulus processing changes during association formation. How associative learning reconfigures neural…”
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Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window by Holtmaat, Anthony, De Paola, Vincenzo, Hübener, Mark, Knott, Graham, Nedivi, Elly, Portera-Cailliau, Carlos, Trachtenberg, Joshua T, Bonhoeffer, Tobias, Chow, David K, Chuckowree, Jyoti, Hofer, Sonja B, Keck, Tara, Lee, Wei-Chung A, Mostany, Ricardo, Mrsic-Flogel, Tom D, Svoboda, Karel, Wilbrecht, Linda

“…To understand the cellular and circuit mechanisms of experience-dependent plasticity, neurons and their synapses need to be studied in the intact brain over…”
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Spatial clustering of tuning in mouse primary visual cortex by Ringach, Dario L., Mineault, Patrick J., Tring, Elaine, Olivas, Nicholas D., Garcia-Junco-Clemente, Pablo, Trachtenberg, Joshua T.

“…The primary visual cortex of higher mammals is organized into two-dimensional maps, where the preference of cells for stimulus parameters is arranged regularly…”
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Parvalbumin Interneurons: All Forest, No Trees by Trachtenberg, Joshua T.

“…There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015)…”
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Local tuning biases in mouse primary visual cortex by Jimenez, Luis O, Tring, Elaine, Trachtenberg, Joshua T, Ringach, Dario L

“…Neurons in primary visual cortex are selective to the orientation and spatial frequency of sinusoidal gratings. In the classic model of cortical organization,…”
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Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex by Baohan, Amy, Ikrar, Taruna, Tring, Elaine, Xu, Xiangmin, Trachtenberg, Joshua T.

“…Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate…”
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Specific Developmental Disruption of Disrupted-in-Schizophrenia-1 Function Results in Schizophrenia-Related Phenotypes in Mice by Li, Weidong, Zhou, Yu, Jentsch, J. David, Brown, Robert A. M., Tian, Xiaoli, Ehninger, Dan, Hennah, William, Peltonen, Leena, Lönnqvist, Jouko, Huttunen, Matti O., Kaprio, Jaakko, Trachtenberg, Joshua T., Silva, Alcino J., Cannon, Tyrone D.

“…Disrupted-in-schizophrenia 1 (DISC1) was initially discovered through a balanced translocation (1;11)(q42.1;q14.3) that results in loss of the C terminus of…”
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Overexpression of calcium-activated potassium channels underlies cortical dysfunction in a model of PTEN-associated autism by Garcia-Junco-Clemente, Pablo, Chow, David K., Tring, Elaine, Lazaro, Maria T., Trachtenberg, Joshua T., Golshani, Peyman

“…De novo phosphatase and tensin homolog on chromosome ten (PTEN) mutations are a cause of sporadic autism. How single-copy loss of PTEN alters neural function…”
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A protocol for preparing GFP-labeled neurons previously imaged in vivo and in slice preparations for light and electron microscopic analysis by Knott, Graham W, Holtmaat, Anthony, Trachtenberg, Joshua T, Svoboda, Karel, Welker, Egbert

“…In vivo imaging of green fluorescent protein (GFP)-labeled neurons in the intact brain is being used increasingly to study neuronal plasticity. However,…”
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Correction: The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study by Gdalyahu, Amos, Lazaro, Maria, Penagarikano, Olga, Golshani, Peyman, Trachtenberg, Joshua T, Geschwind, Daniel H

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Competition, inhibition, and critical periods of cortical plasticity by Trachtenberg, Joshua T

“…Highlights • Experience-dependent maturation of inhibition strengthens ipsilateral eye inputs. • Once established, inhibition is detrimental to competitive…”
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Ipsilateral Eye Cortical Maps Are Uniquely Sensitive to Binocular Plasticity by Faguet, Joshua, Maranhao, Bruno, Smith, Spencer L, Trachtenberg, Joshua T

“…Department of Neurobiology, The David Geffen School of Medicine, UCLA, Los Angeles, California Submitted 7 August 2008; accepted in final form 27 November 2008…”
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