Search Results - "Trabulo, M"

TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression by Ottaviani, Silvia, Stebbing, Justin, Frampton, Adam E., Zagorac, Sladjana, Krell, Jonathan, de Giorgio, Alexander, Trabulo, Sara M., Nguyen, Van T. M., Magnani, Luca, Feng, Hugang, Giovannetti, Elisa, Funel, Niccola, Gress, Thomas M., Jiao, Long R., Lombardo, Ylenia, Lemoine, Nicholas R., Heeschen, Christopher, Castellano, Leandro

“…TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated…”
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MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3 by Cioffi, Michele, Vallespinos-Serrano, Mireia, Trabulo, Sara M., Fernandez-Marcos, Pablo Jose, Firment, Ashley N., Vazquez, Berta N., Vieira, Catarina R., Mulero, Francesca, Camara, Juan A., Cronin, Ultan P., Perez, Manuel, Soriano, Joaquim, G. Galvez, Beatriz, Castells-Garcia, Alvaro, Haage, Verena, Raj, Deepak, Megias, Diego, Hahn, Stephan, Serrano, Lourdes, Moon, Anne, Aicher, Alexandra, Heeschen, Christopher

“…Conquering obesity has become a major socioeconomic challenge. Here, we show that reduced expression of the miR-25-93-106b cluster, or miR-93 alone, increases…”
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The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1 by Cioffi, Michele, Trabulo, Sara M, Vallespinos, Mireia, Raj, Deepak, Kheir, Tony Bou, Lin, Meng-Lay, Begum, Julfa, Baker, Ann-Marie, Amgheib, Ala, Saif, Jaimy, Perez, Manuel, Soriano, Joaquim, Desco, Manuel, Gomez-Gaviro, Maria Victoria, Cusso, Lorena, Megias, Diego, Aicher, Alexandra, Heeschen, Christopher

“…The stromal microenvironment controls response to injury and inflammation, and is also an important determinant of cancer cell behavior. However, our…”
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Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts by Hermann, Patrick C, Trabulo, Sara M, Sainz, Jr, Bruno, Balic, Anamaria, Garcia, Elena, Hahn, Stephan A, Vandana, Mallaredy, Sahoo, Sanjeeb K, Tunici, Patrizia, Bakker, Annette, Hidalgo, Manuel, Heeschen, Christopher

“…In spite of intense research efforts, pancreatic ductal adenocarcinoma remains one of the most deadly malignancies in the world. We and others have previously…”
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Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression by Ottaviani, Silvia, Stebbing, Justin, Frampton, Adam E., Zagorac, Sladjana, Krell, Jonathan, de Giorgio, Alexander, Trabulo, Sara M., Nguyen, Van T. M., Magnani, Luca, Feng, Hugang, Giovannetti, Elisa, Funel, Niccola, Gress, Thomas M., Jiao, Long R., Lombardo, Ylenia, Lemoine, Nicholas R., Heeschen, Christopher, Castellano, Leandro

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells by Cioffi, Michele, Trabulo, Sara M, Sanchez-Ripoll, Yolanda, Miranda-Lorenzo, Irene, Lonardo, Enza, Dorado, Jorge, Reis Vieira, Catarina, Ramirez, Juan Carlos, Hidalgo, Manuel, Aicher, Alexandra, Hahn, Stephan, Sainz, Jr, Bruno, Heeschen, Christopher

“…Cancer stem cells (CSCs) represent the root of many solid cancers including pancreatic ductal adenocarcinoma, are highly chemoresistant and represent the…”
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Hospital discharge after uncomplicated ST elevation acute myocardial infarction: How early is safe? by Certo Pereira, J, Presume, J, Ferreira, J, Trabulo, M, Tralhao, A, Almeida, M, Mendes, M

“…Abstract Background International guidelines recommend that hospital discharge within 48–72h is appropriate in selected low-risk patients admitted for ST…”
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ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation by Dumartin, L, Alrawashdeh, W, Trabulo, S M, Radon, T P, Steiger, K, Feakins, R M, di Magliano, M P, Heeschen, C, Esposito, I, Lemoine, N R, Crnogorac-Jurcevic, T

“…The mechanisms of initiation of pancreatic ductal adenocarcinoma (PDAC) are still largely unknown. In the present study, we analysed the role of anterior…”
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ClinicAl verSus algorIthmic predictioN of Obstructive Coronary Artery Disease - the CASINO study by Paiva, M, Carvalho, R A, Maltes, S, Presume, J, Brizido, C, Matos, D, Marta, L, Costa, F M, Madeira, S, Trabulo, M, Ferreira, J, Freitas, P, Ferreira, A

“…Abstract Background The estimation of pretest probability (PTP) is a key step when evaluating patients with suspected coronary artery disease (CAD). Current…”
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Prognostic impact of aborted cardiac arrest in patients with acute myocardial infarction by Presume, J, Gomes, D, Strong, C, Tralhao, A, Aguiar, C, Trabulo, M, Almeida, M, Ferreira, J, Mendes, M

“…Abstract Background Aborted cardiac arrest (ACA) during the acute ischaemic phase is a relatively frequent but often undervalued complication of acute…”
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Evaluation of functional mitral regurgitation profile in a real-world cohort of heart failure patients and the referral rate of these patients by Presume, J, Lopes, P, Albuquerque, F, Freitas, P, Trabulo, M, Joao Andrade, M, Mendes, M, Ribeiras, R

“…Abstract Introduction Patients with heart failure and reduced ejection fraction (HFrEF) frequently have significant functional mitral regurgitation (FMR),…”
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Lipoprotein(a) levels in acute myocardial infarction patients and their associations with prior events and coronary artery disease severity: a real-world cohort study by Azevedo, S, Da Silva Correia, D, Barbosa Sousa, R, Amador, R, Sousa Paiva, M, Gomes, D, Certo Pereira, J, Carvalho, R, Bello, R, Fonseca, I, Tralhao, A, Trabulo, M, Figueira, J, Sousa Almeida, M, Ferreira, J

“…Abstract Introduction Circulating lipoprotein(a) [Lp(a)] has been associated with the risk of atherosclerotic coronary artery disease (CAD) and is an emergent…”
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Relative contribution of imaging techniques for the contemporary diagnosis of infective endocarditis: a single-center experience by Barbosa Sousa, R, Da Silva Correia, D, Azevedo, S, Gomes, D, Certo Pereira, J, Sousa Paiva, M, Almeida Carvalho, R, Trabulo, M, Ribeiras, R, Ferreira, A, Abecasis, M, Ferreira, J

“…Abstract Introduction In developed countries, the incidence of infective endocarditis (IE) is up to 6 cases per 100,000 individuals and in-hospital mortality…”
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Severe rheumatic mitral stenosis – analysis of clinical and echocardiographic very long-term outcomes after percutaneous mitral balloon valvuloplasty by Presume, J, Paiva, M, Gomes, D, Albuquerque, F, Guerreiro, S, Marta, L, Freitas, P, Trabulo, M, Abecasis, J, Andrade, M J, Ribeiras, R

“…Abstract Introduction Mitral balloon valvuloplasty (MBV) is the guideline recommended treatment for symptomatic severe mitral stenosis (MS) with suitable…”
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Attainment of LDL-cholesterol goals in patients with previous myocardial infarction: a real-world cross-sectional analysis by Gomes, D, Sousa Paiva, M, Freitas, P, Albuquerque, F, Lima, R, Reis Santos, R, Presume, J, Bello, R, Maltes, S, Trabulo, M, Aguiar, C, Ferreira, J, Ferreira, A M, Mendes, M

“…Abstract Background ESC guidelines recommend an LDL-cholesterol (LDL-C) <55mg/dL for patients with established cardiovascular disease. While the Friedewald’s…”
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Regurgitant volume to left ventricular end-diastolic volume ratio: the quest to identify Disproportionate MR is not over by Albuquerque, F, M Lopes, P, Freitas, P, M Ferreira, A, Abecasis, J, Trabulo, M, Canada, M, Ribeiras, R, Mendes, M, Joao Andrade, M

“…Abstract Background Quantification of secondary mitral valve regurgitation (SMR) remains challenging. Proportionate and Disproportionate SMR provides a…”
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Incremental prognostic value of worsening renal function parameters in addition to the GRACE score in patients with acute coronary syndrome by Presume, J, Gomes, D, Albuquerque, F, Strong, C, Trabulo, M, De Araujo Goncalves, P, Campante Teles, R, Almeida, M, Mendes, M, Ferreira, J

“…Abstract Background Baseline renal function, one of the parameters included in the GRACE score, has prognostic relevance in patients admitted for acute…”
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Anticipating recurrent ischemic events after an acute coronary syndrome: validation and application of the SMART-REACH score by Gomes, D, Presume, J, Albuquerque, F, Lopes, P, Sousa Paiva, M, Reis Santos, R, Aguiar, C, Ferreira, J, Trabulo, M, Mendes, M

“…Abstract Background The SMART-REACH score (SRS) was developed to predict the risk of major adverse cardiovascular events in ambulatory patients with…”
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Validation of a novel framework defining the acceptable standard of care for heart failure with reduced ejection fraction by Lopes, P, Albuquerque, F, Freitas, P, Presume, J, Rocha, B, Cunha, G, Strong, C, Tralhao, A, Trabulo, M, Ferreira, J, Ventosa, A, Aguiar, C, Mendes, M, Ferreira, A

“…Abstract Background In heart failure with reduced ejection fraction (HFrEF), uptitration of neurohormonal antagonists to trial-proven doses shown to reduce…”
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Outcomes of culture-negative vs. culture-positive infective endocarditis: the ESC-EORP EURO-ENDO registry by Kong, William K F, Salsano, Antonio, Giacobbe, Daniele Roberto, Popescu, Bogdan A, Laroche, Cécile, Duval, Xavier, Schueler, Robert, Moreo, Antonella, Colonna, Paolo, Piper, Cornelia, Calvo-Iglesias, Francisco, Badano, Luigi P, Srdanovic, Ilija, Boutoille, David, Huttin, Olivier, Stöhr, Elisabeth, Timóteo, Ana Teresa, Vaskelyte, Jolanta Justina, Sadeghpour, Anita, Tornos, Pilar, Abid, Leila, Poh, Kian Keong, Habib, Gilbert, Lancellotti, Patrizio

“…Abstract Aim Fatality of infective endocarditis (IE) is high worldwide, and its diagnosis remains a challenge. The objective of the present study was to…”
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