Influence of stiripentol on perampanel serum levels
•Perampanel serum levels increase linearly with stiripentol doses.•Increasing perampanel can fast lead to side effects, when stiripentol is given, too.•Perampanel serum level monitoring seems advisable, when stiripentol is also given. Stiripentol is an orphan drug successfully used in combination wi...
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| Published in: | Epilepsy research Vol. 164; p. 106367 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Netherlands
Elsevier B.V
01-08-2020
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | •Perampanel serum levels increase linearly with stiripentol doses.•Increasing perampanel can fast lead to side effects, when stiripentol is given, too.•Perampanel serum level monitoring seems advisable, when stiripentol is also given.
Stiripentol is an orphan drug successfully used in combination with valproate and clobazam in the treatment of Dravet syndrome. Perampanel has also been added by experts. In this retrospective study, we investigated the influence of stiripentol on perampanel serum levels by using the doses and corresponding perampanel serum levels of 10 patients. The impact of stiripentol on the perampanel serum levels was significant as shown in a linear regression analysis, with perampanel serum levels increasing linearly with the stiripentol doses. We conclude that dose adjustments of stiripentol and perampanel when administered together, should be done carefully to avoid side effects or even severe intoxication. Hence, perampanel serum level monitoring seems advisable. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0920-1211 1872-6844 |
| DOI: | 10.1016/j.eplepsyres.2020.106367 |