Search Results - "Traber, Rene"

Cyclosporins:  Structure−Activity Relationships for the Inhibition of the Human FPR1 Formylpeptide Receptor by Loor, Francis, Tiberghien, Françoise, Wenandy, Tom, Didier, Agnès, Traber, Rene

“…The human formylpeptide receptor (FPR) is a seven-transmembranous G-protein-coupled receptor (7TM-GPCR) for chemotactic peptides of bacterial origins, possibly…”
Get full text

Cyclosporins:  Structure−Activity Relationships for the Inhibition of the Human MDR1 P-Glycoprotein ABC Transporter by Loor, Francis, Tiberghien, Françoise, Wenandy, Tom, Didier, Agnès, Traber, René

“…Cyclic undecapeptide cyclo-[MeBmt-Abu-MeGly-MeLeu-Val-MeLeu-Ala-d-Ala-MeLeu-MeLeu-MeVal], the immunosuppressive and antifungal antibiotic cyclosporin A (CsA),…”
Get full text

Intermediates of rifamycin polyketide synthase produced by an Amycolatopsis mediterranei mutant with inactivated rifF gene by Stratmann, Ansgar, Toupet, Christiane, Schilling, Wolfgang, Traber, Rene, Oberer, Lukas, Schupp, Thomas

“…Novartis Pharma AG, Research, Core Technology Area, CH-4002 Basel , Switzerland 1 Author for correspondence: Thomas Schupp. Tel: +41 61 32 47903. Fax: +41 61…”
Get full text

New insights into rifamycin B biosynthesis: isolation of proansamycin B and 34a-deoxy-rifamycin W as early macrocyclic intermediates indicating two separated biosynthetic pathways by Stratmann, Ansgar, Schupp, Thomas, Toupet, Christiane, Schilling, Wolfgang, Oberer, Lukas, Traber, René

“…Proansamycin B, the formerly postulated intermediate of rifamycin B biosynthesis, was isolated from cultures of the Amycolatopsis mediterranei mutant F1/24…”
Get more information

Receptor-Induced Conformation Change of the Immunosuppressant Cyclosporin A by Wüthrich, Kurt, von Freyberg, Berthold, Weber, Christoph, Wider, Gerhard, Traber, René, Widmer, Hans, Braun, Werner

“…The immunosuppressive agent Cyclosporin A (CsA) is the favored therapeutic agent for prevention of graft rejection in clinical organ transplantation, has…”
Get full text

Solvents for aromatic SRN1 reactions by Bunnett, J. F, Scamehorn, R. G, Traber, Rene P

Get full text

Cyclosporins--new analogues by precursor directed biosynthesis by Traber, R, Hofmann, H, Kobel, H

“…Cyclosporin A (ciclosporin), a potent and clinically important immunosuppressive drug (Sandimmun), represents the main component of a group of over 25 closely…”
Get more information

Biosynthesis of the Unusual Amino Acid (4R)-4-[(E)-2-Butenyl]-4-methyl-l-threonine of Cyclosporin A:  Enzymatic Analysis of the Reaction Sequence Including Identification of the Methylation Precursor in a Polyketide Pathway by Offenzeller, Manuela, Santer, Gerhard, Totschnig, Klaus, Su, Zhuang, Moser, Hanspeter, Traber, René, Schneider-Scherzer, Elisabeth

“…3(R)-Hydroxy-4(R)-methyl-6(E)-octenoic acid, the C9-backbone of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-l-threonine (Bmt), is biosynthesized as…”
Get full text

Microbial biotransformation products of cyclosporin A by Kuhnt, M, Bitsch, F, France, J, Hofmann, H, Sanglier, J J, Traber, R

“…In order to mimic the human metabolic pathway of cyclosporin A (CyA) a total of 28 bacterial and 72 fungal strains was screened for their ability to transform…”
Get more information

Observations concerning the scope and mechanism of photostimulated reactions of aryl iodides with diethyl phosphite ion. A remarkable difference in behavior between m- and p-chloroiodobenzene by Bunnett, Joseph F, Traber, Rene P

Get full text

Light and dark reactions of o-haloiodobenzenes with diethyl phosphite ion by Bard, Raymond R, Bunnett, Joseph F, Traber, Rene P

Get full text

Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase: comparison of the substrate specificities of the related multifunctional polypeptides by Lawen, A, Traber, R

“…The recently discovered multifunctional polypeptide cyclosporin synthetase is capable of synthesizing the cyclic undecapeptide cyclosporin A in a batch…”
Get full text

Induction of rapid IL-1 beta mRNA degradation in THP-1 cells mediated through the AU-rich region in the 3'UTR by a radicicol analogue by Kastelic, T, Schnyder, J, Leutwiler, A, Traber, R, Streit, B, Niggli, H, MacKenzie, A, Cheneval, D

“…A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) secretion from THP-1 cells…”
Get full text

Anti HIV-1 activity of a hydrophilic cyclosporin derivative with improved binding affinity to cyclophilin A by Papageorgiou, Christos, Sanglier, Jean-Jacques, Traber, René

“…Due to its conformation, the hydrophilic compound [(D)MeSer-3, (4-OH)MeLeu-4] cyclosporin, 3, shows high affinity for cyclophilin A. This property, together…”
Get full text

Induction of Rapid IL-β mRNA Degradation in THP-1 Cells Mediated Through the AU-Rich Region in the 3′UTR by a Radicicol Analogue by Kastelic, Tania, Schnyder, Jög, Leutwiler, Albert, Traber, René, Streit, Bruno, Niggli, Heinz, MacKenzie, Andrew, Cheneval, Dominique

“…A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1β) and tumour necrosis factor alpha (tnf-α) secretion from THP-1 cells. If added…”
Get full text

In vitro biosynthesis of [Thr2,Leu5,D-Hiv8,Leu10]-cyclosporin, a cyclosporin-related peptolide, with immunosuppressive activity by a multienzyme polypeptide by Lawen, A, Traber, R, Geyl, D

“…A new cyclic peptolide (SDZ 214-103), which is produced by the fungus Cylindrotrichumoligospermum (Corda) BONORDEN (Dreyfuss, M. M., Schreier, M. H.,…”
Get full text

Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. Identification of 3(R)-hydroxy-4(R)-methyl-6(E)-octenoic acid as a key intermediate by enzymatic in vitro synthesis and by in vivo labeling techniques by Offenzeller, M, Su, Z, Santer, G, Moser, H, Traber, R, Memmert, K, Schneider-Scherzer, E

“…The biosynthesis of (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine (abbreviation: Bmt, systematic name: 2(S)-amino-3(R)-hydroxy-4(R)-methyl-6(E)-octenoic acid) is…”
Get full text

Selective 13 C‐labelling of cyclosporin A by SENN, Hans, WEBER, Christoph, KOBEL, Hans, TRABER, René

“…Cyclosporin A is biosynthetically labelled with 13 C by growing an overproducing strain of Tolypocladium inflatum on minimal media containing either [1‐ 13…”
Get full text

Selective 13C‐labelling of cyclosporin A by SENN, Hans, WEBER, Christoph, KOBEL, Hans, TRABER, René

“…Cyclosporin A is biosynthetically labelled with 13C by growing an overproducing strain of Tolypocladium inflatum on minimal media containing either [1‐13C]‐,…”
Get full text

Isolation of (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine, the characteristic structural element of cyclosporins, from a blocked mutant of Tolypocladium inflatum by Sanglier, J J, Traber, R, Buck, R H, Hofmann, H, Kobel, H

“…By mutagenic treatment of a strain of Tolypocladium inflatum, a cyclosporin non-producing mutant was obtained which accumulated the characteristic building…”
Get more information