HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals

HIV-specific mucosal and cellular immunity was analyzed in heterosexual couples discordant for HIV status in serum and in HIV-unexposed controls. HIV-specific IgA but not IgG was present in urine and vaginal wash samples from HIV-exposed seronegative individuals (ESN), whereas both IgA and IgG were...

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Bibliographic Details
Published in:	Nature medicine Vol. 3; no. 11; pp. 1250 - 1257
Main Authors:	Mazzoli, Sandra, Trabaironi, Daria, Caputo, Sergio Lo, Piconi, Stefania, Blé, Claudio, Meacci, Francesca, Ruzzante, Stefania, Salvi, Alessanda, Semplici, Francesca, Longhi, Renato, Fusi, Maria Luisa, Tofani, Nadia, Biasin, Mara, Villa, Maria Luisa, Mazzotta, Francesco, Clerici, Mario
Format:	Journal Article
Language:	English
Published:	United States 01-11-1997
Subjects:	Adult AIDS/HIV Blotting, Western Chemokines, CC - metabolism DNA, Complementary - urine Female Gene Products, env - metabolism Heterosexuality HIV Seronegativity - immunology HIV Seropositivity - immunology HIV-1 - genetics HIV-1 - immunology human immunodeficiency virus Humans Immunity, Cellular Immunity, Mucosal Immunoglobulin A - analysis Immunoglobulin G - analysis Interleukin-2 - biosynthesis Male Middle Aged Receptors, CCR5 - biosynthesis RNA, Viral - blood Sexual Partners Vagina - immunology Vagina - virology
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Summary:	HIV-specific mucosal and cellular immunity was analyzed in heterosexual couples discordant for HIV status in serum and in HIV-unexposed controls. HIV-specific IgA but not IgG was present in urine and vaginal wash samples from HIV-exposed seronegative individuals (ESN), whereas both IgA and IgG were observed in their HIV-seropositive partners; antibodies were not detected in low-risk controls. Envelope protein (Env) peptide-stimulated interleukin-2 (IL-2) production by peripheral blood mononuclear cells (PBMCs) was detected in 9 out of 16 ESNs, 5 out of 16 HIV-infected patients and 1 out of 50 controls. Env peptide-stimulated PBMCs of ESNs produced more IL-2 and less IL-10 compared with those of HIV-infected individuals; no differences were observed in chemokine production or in CCR5 expression. These data demonstrate that a compartmentalized immune response to pathogens is possible in humans and raise the possibility of protective roles for cell-mediated immunity and mucosal IgA in HIV-seronegative individuals exposed to HIV.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm1197-1250