Abstract P2-18-09: Effects of diet after early breast cancer treatment: Systematic review and meta-analysis of clinical trials
Purpose: Randomized clinical trials are inconclusive regarding the role of dietary interventions in anthropometric measurements, quality of life, and survival in breast cancer patients. Our aim was to conduct a systematic review and meta-analysis to assess the effects of diet on these outcomes in wo...
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| Published in: | Cancer research (Chicago, Ill.) Vol. 80; no. 4_Supplement; pp. P2 - P2-18-09 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
15-02-2020
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| Online Access: | Get full text |
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| Summary: | Purpose: Randomized clinical trials are inconclusive regarding the role of dietary interventions in anthropometric measurements, quality of life, and survival in breast cancer patients. Our aim was to conduct a systematic review and meta-analysis to assess the effects of diet on these outcomes in women who went through curative treatment of early-stage breast cancer.Methods: Pubmed, Embase, Cochrane Library were searched for randomized clinical trial comparing dietary interventions (individualized dietary counseling, prescription of a specific diet or other) with usual care in women that were treated for breast cancer. Primary outcomes were overall survival and disease-free survival, secondary outcomes were weight loss and change in body mass index.Results: We found 12 clinical trials eligible for analysis. Only two of them reported overall and disease-free survival, whereas six reported data for body mass index and four for weight. The HR for mortality and disease-free survival was 0.91 (95% CI 0.77-1,07, p=0.25) and 0.92 (CI 95% 0.79-1.08, p=0.31) for the intervention group compared to the control group, respectively. Diet intervention was associated with body mass index reduction in those subjects who received a specific diet instead of counseling or other types of intervention (-0.67 CI 95% -1.14 to -0.21). The weight did not differ between intervention and control groups.Conclusions: Despite increasing survival among breast cancer patients there is still a lack of prospective data regarding the effects of dietary interventions in this population. We found positive association between prescription of specific diets in terms of anthropometric measure, but neither difference in overall nor disease-free survival.
Citation Format: Henrique AV Träsel, Frederico S Falcetta, Fernando K Almeida, Mariana RR Falcetta, Daniela D Rosa. Effects of diet after early breast cancer treatment: Systematic review and meta-analysis of clinical trials [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P2-18-09. |
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| ISSN: | 0008-5472 1538-7445 |
| DOI: | 10.1158/1538-7445.SABCS19-P2-18-09 |