Search Results - "Tozer, Matthew J"

Scalable synthesis of functionalised 2-pyridones via [4+2] cycloaddition reactions of 2-pyrazinones and alkynylboronates by Harker, Wesley R.R., Delaney, Patrick M., Simms, Michael, Tozer, Matthew J., Harrity, Joseph P.A.

“…The multigram synthesis of N-protected 2-pyridone boronic acid derivatives via a [4+2] cycloaddition of alkynylboronates with 2-pyrazinones is presented. The…”
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Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin‑2 Receptor: Structure–Activity Relationships and Optimization by Zirimwabagabo, Jean-Olivier, Jailani, Ameera B. A, Avgoustou, Paris, Tozer, Matthew J, Gibson, Karl R, Glossop, Paul A, Mills, James E. J, Porter, Roderick A, Blaney, Paul, Wang, Ning, Skerry, Timothy M, Richards, Gareth O, Harrity, Joseph P. A

“…Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly…”
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A Study of (Binap)(enyne)tetracarbonyldicobalt(0) Complexes by Gibson, Susan E., Hardick, David J., Haycock, Peter R., Kaufmann, Karina A. C., Miyazaki, Ayako, Tozer, Matthew J., White, Andrew J. P.

“…Four (binap)(enyne)tetracarbonyldicobalt(0) complexes have been synthesised and their reactivity monitored by variable temperature 31P NMR spectroscopy…”
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Pendant Alkenes Promote Cobalt−Cobalt Bond Cleavage in (Alkyne)(binap)tetracarbonyldicobalt(0) Complexes by Gibson, Susan E, Kaufmann, Karina A. C, Haycock, Peter R, White, Andrew J. P, Hardick, David J, Tozer, Matthew J

“…Heating (alkyne)(binap)tetracarbonyldicobalt(0) complexes bearing pendant alkenes leads to cleavage of the cobalt−cobalt bond and generation of the mononuclear…”
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Methods for the synthesis of gem-difluoromethylene compounds by Tozer, Matthew J., Herpin, Timothée F.

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Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin‑2 Receptor by Avgoustou, Paris, Jailani, Ameera B. A, Zirimwabagabo, Jean-Olivier, Tozer, Matthew J, Gibson, Karl R, Glossop, Paul A, Mills, James E. J, Porter, Roderick A, Blaney, Paul, Bungay, Peter J, Wang, Ning, Shaw, Alice P, Bigos, Kamilla J. A, Holmes, Joseph L, Warrington, Jessica I, Skerry, Timothy M, Harrity, Joseph P. A, Richards, Gareth O

“…The hormone adrenomedullin has both physiological and pathological roles in biology. As a potent vasodilator, adrenomedullin is critically important in the…”
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Synthesis of Cyclic Sulfonamides through Intramolecular Diels−Alder Reactions by Greig, Ian R, Tozer, Matthew J, Wright, Paul T

“…Substituted 2,3,3a,4,5,7a-hexahydrobenzo[d]isothiazole 1,1-dioxides and 3,4,4a,5,6,8a-hexahydro-2H-benzo[e][1,2]thiazine 1,1-dioxides, novel cyclic…”
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Identification of an Asymmetric Pauson−Khand Precatalyst by Gibson, Susan E, Lewis, Sara E, Loch, Jennifer A, Steed, Jonathan W, Tozer, Matthew J

“…X-ray crystallographic analysis of red crystals formed on mixing octacarbonyldicobalt(0) and BINAP, combined with NMR evidence obtained from a catalytic…”
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New routes to beta-cycloalkylalanine derivatives using serine-derived organozinc reagents by Carrillo-Marquez, Tomas, Caggiano, Lorenzo, Jackson, Richard F W, Grabowska, Urszula, Rae, Alastair, Tozer, Matthew J

“…Two distinct routes to beta-cycloalkylalanine derivatives have been developed. The first route employs the reaction of the iodoalanine-derived zinc-copper…”
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Optimization of the in Vitro and in Vivo Properties of a Novel Series of 2,4,5-Trisubstituted Imidazoles as Potent Cholecystokinin-2 (CCK2) Antagonists by Buck, Ildiko M, Black, James W, Cooke, Tracey, Dunstone, David J, Gaffen, John D, Griffin, Eric P, Harper, Elaine A, Hull, Robert A. D, Kalindjian, S. Barret, Lilley, Elliot J, Linney, Ian D, Low, Caroline M. R, McDonald, Iain M, Pether, Michael J, Roberts, Sonia P, Shankley, Nigel P, Shaxted, Mark E, Steel, Katherine I. M, Sykes, David A, Tozer, Matthew J, Watt, Gillian F, Walker, Martin K, Wright, Laurence, Wright, Paul T

“…The systematic optimization of the structure of a novel 2,4,5-trisubstituted imidazole-based cholecystokinin-2 (CCK2) receptor antagonist afforded analogues…”
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CCK2 receptor antagonists containing the conformationally constrained phenylalanine derivatives, including the new amino acid Xic by GIBSON, Susan E, GUILLO, Nathalie, JONES, Jerome O, BUCK, Ildiko M, KALINDJIAN, S. Barret, ROBERTS, Sonia, TOZER, Matthew J

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2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a New Template for the Design of CCK2 Receptor Antagonists by McDonald, Iain M, Dunstone, David J, Kalindjian, S. Barret, Linney, Ian D, Low, Caroline M. R, Pether, Michael J, Steel, Katherine I. M, Tozer, Matthew J, Vinter, J. G

“…A novel series of nonpeptide CCK2 receptor antagonists has been prepared, in which 2,7-dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine (5) was used as a…”
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ω-(Imidazol-4-yl)alkane-1-sulfonamides: A new series of potent histamine H3 receptor antagonists by TOZER, Matthew J, BUCK, Ildiko M, COOKE, Tracey, KALINDJIAN, S. Barret, PETHER, Michael J, STEEL, Katherine I. M

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Synthesis and structural analysis of dehydrophenylalanine cyclophanes by Gibson, Susan E, Jones, Jerome O, Kalindjian, S Barret, Knight, Jamie D, Steed, Jonathan W, Tozer, Matthew J

“…The syntheses and structures of three cyclophanes containing two (Z)-dehydrophenylalanine residues are reported; the length of the tethers between the two…”
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Nonpeptide Cholecystokinin-2 Receptor Agonists by Kalindjian, S. Barret, Dunstone, David J, Low, Caroline M. R, Pether, Michael J, Roberts, Sonia P, Tozer, Matthew J, Watt, Gillian F, Shankley, Nigel P

“…In the course of structural explorations around a series of potent CCK2 receptor antagonists, it was noted that simple N-methylation of the indolic N−H in the…”
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Non-Peptide Cholecystokinin-B/Gastrin Receptor Antagonists Based on Bicyclic, Heteroaromatic Skeletons by Kalindjian, S. Barret, Buck, Ildiko M, Davies, Jonathan M. R, Dunstone, David J, Hudson, Martin L, Low, Caroline M. R, McDonald, Iain M, Pether, Michael J, Steel, Katherine I. M, Tozer, Matthew J, Vinter, J. G

“…A series of potent and selective cholecystokinin-B/gastrin receptor antagonists based on the dibenzobicyclo[2.2.2]octane (BCO) skeleton which have recently…”
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Improving the Affinity and Selectivity of a Nonpeptide Series of Cholecystokinin-B/Gastrin Receptor Antagonists Based on the Dibenzobicyclo[2.2.2]octane Skeleton by Kalindjian, S. Barret, Buck, Ildiko M, Cushnir, Julia R, Dunstone, David J, Hudson, Martin L, Low, Caroline M. R, McDonald, Iain M, Pether, Michael J, Steel, Katherine I. M, Tozer, Matthew J

“…We have recently described a novel series of nonpeptidic cholecystokinin-B (CCKB)/gastrin receptor antagonists based on a dibenzobicyclo[2.2.2]octane skeleton…”
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Towards control of χ-space: Conformationally constrained analogues of Phe, Tyr, Trp and His by Gibson (née Thomas), Susan E., Guillo, Nathalie, Tozer, Matthew J.

“…A review is presented of the synthetic routes available to conformationally constrained analogues of aromatic amino acids together with an overview of their…”
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Synthesis of meta- and paracyclophanes containing unsaturated amino acid residues by Gibson, Susan E., Jones, Jerome O., Kalindjian, S.Barret, Knight, Jamie D., Mainolfi, Nello, Rudd, Matthew, Steed, Jonathan W., Tozer, Matthew J., Wright, Paul T.

“…[7.7], [8.8], [9.9] and [13.13] Paracyclophanes and [9.9] and [13.13] metacyclophanes containing two unsaturated amino acid residues have been synthesised. An…”
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CCK(2) receptor antagonists containing the conformationally constrained phenylalanine derivatives, including the new amino acid Xic by Gibson, Susan E, Guillo, Nathalie, Jones, Jerome O, Buck, Ildiko M, Kalindjian, S Barret, Roberts, Sonia, Tozer, Matthew J

“…The conformationally constrained analogues of phenylalanine, tetrahydroisoquinoline-3-carboxylic acid (Tic), Sic, Hic and Nic, and the new amino acid Xic have…”
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