Search Results - "Toyos, Juan R. de los"

Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts by Zhu, Kaiyi, Cai, Lingyi, Cui, Chenqian, de los Toyos, Juan R, Anastassiou, Dimitris

“…During the last ten years, many research results have been referring to a particular type of cancer-associated fibroblasts associated with poor prognosis,…”
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Overexpression of COL11A1 by cancer-associated fibroblasts: clinical relevance of a stromal marker in pancreatic cancer by García-Pravia, Carmen, Galván, José A, Gutiérrez-Corral, Natalia, Solar-García, Lorena, García-Pérez, Eva, García-Ocaña, Marcos, Del Amo-Iribarren, Jokin, Menéndez-Rodríguez, Primitiva, García-García, Juan, de Los Toyos, Juan R, Simón-Buela, Laureano, Barneo, Luis

“…The collagen11A1 (COL11A1) gene is overexpressed in pancreatic cancer. The expression of COL11A1 protein could be involved in desmoplastic events in pancreatic…”
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A new aggressive xenograft model of human colon cancer using cancer-associated fibroblasts by Fernando-Macías, Ester, Fernández-García, Maria Teresa, García-Pérez, Eva, Porrero Guerrero, Belén, López-Arévalo, Camilo, Rodríguez-Uría, Raquel, Sanz-Navarro, Sandra, Vázquez-Villa, José Fernando, Muñíz-Salgueiro, María Carmen, Suárez-Fernández, Laura, Galván, José A, Barneo-Caragol, Clara, García-Ocaña, Marcos, de Los Toyos, Juan R, Barneo-Serra, Luis

“…Colorectal cancer is the second leading cause of cancer death. Almost half of the patients present recurrence within 5 years after the treatment of the primary…”
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Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia by Witzenrath, Martin, Gutbier, Birgitt, Hocke, Andreas C, Schmeck, Bernd, Hippenstiel, Stefan, Berger, Katharina, Mitchell, Timothy J, de los Toyos, Juan R, Rosseau, Simone, Suttorp, Norbert, Schütte, Hartwig

“…OBJECTIVE:Acute respiratory failure is a significant complication of severe pneumococcal pneumonia. In a mouse model, we observed early-onset lung…”
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Prediction of Linear B Cell Epitopes in Proteins by de Los Toyos, Juan R

“…The accurate prediction of B cell epitopes is crucial for the design and development of vaccines, especially of those preventive for emerging pathogenic…”
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Aptamers targeting a tumor-associated extracellular matrix component: The human mature collagen XIα1 by Lorenzo-Gómez, Ramón, Miranda-Castro, Rebeca, de los Toyos, Juan R., de-los-Santos-Álvarez, Noemí, Lobo-Castañón, María Jesús

“…The extracellular matrix (ECM) plays an essential role in tumor progression and invasion through its continuous remodeling. The growth of most carcinomas is…”
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Protection against Pneumococcal Pneumonia in Mice by Monoclonal Antibodies to Pneumolysin by GARCIA-SUAREZ, Maria Del, CIMA-CABAL, Maria Dolores, FLOREZ, Noelia, GARCIA, Pilar, CERNUDA-CERNUDA, Rafael, ASTUDILLO, Aurora, VAZQUEZ, Fernando, DE LOS TOYOS, Juan R, MENDEZ, F. Javier

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Performance of a Pneumolysin Enzyme-Linked Immunosorbent Assay for Diagnosis of Pneumococcal Infections by del Mar García-Suárez, María, Cima-Cabal, María Dolores, Villaverde, Roberto, Espinosa, Emma, Falguera, Miquel, de Los Toyos, Juan R, Vázquez, Fernando, Méndez, Francisco J

“…A pneumolysin-specific enzyme-linked immunosorbent assay (PLY-ELISA) for the detection of pneumolysin in urine was developed and evaluated in comparison with…”
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A competitive assay for the detection of a 16-mer peptide from α1 chain of human collagen XI by Lorenzo-Gómez, Ramón, Casero-Álvarez, Alfonso, Miranda-Castro, Rebeca, García-Ocaña, Marcos, de los Toyos, Juan R., de-los-Santos-Alvarez, Noemí, Lobo-Castañón, M. Jesús

“…Characterization of extracellular matrix (ECM) is becoming more and more important to decipher cancer progression. Constant remodeling results in ECM…”
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COL11A1/(pro)collagen 11A1 expression is a remarkable biomarker of human invasive carcinoma-associated stromal cells and carcinoma progression by Vázquez-Villa, Fernando, García-Ocaña, Marcos, Galván, José A., García-Martínez, Jorge, García-Pravia, Carmen, Menéndez-Rodríguez, Primitiva, Rey, Carmen González-del, Barneo-Serra, Luis, de los Toyos, Juan R.

“…The COL11A1 human gene codes for the α1 chain of procollagen 11A1 and mature collagen 11A1, an extracellular minor fibrillar collagen. Under regular…”
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Validation of COL11A1/procollagen 11A1 expression in TGF-β1-activated immortalised human mesenchymal cells and in stromal cells of human colon adenocarcinoma by Galván, José A, García-Martínez, Jorge, Vázquez-Villa, Fernando, García-Ocaña, Marcos, García-Pravia, Carmen, Menéndez-Rodríguez, Primitiva, González-del Rey, Carmen, Barneo-Serra, Luis, de los Toyos, Juan R

“…The human COL11A1 gene has been shown to be up-regulated in stromal cells of colorectal tumours, but, so far, the immunodetection of procollagen 11A1, the…”
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Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding by Huergo-Zapico, Leticia, Gonzalez-Rodriguez, Ana P., Contesti, Juan, Gonzalez, Esther, López-Soto, Alejandro, Fernandez-Guizan, Azahara, Acebes-Huerta, Andrea, de los Toyos, Juan R., Lopez-Larrea, Carlos, Groh, Veronika, Spies, Thomas, Gonzalez, Segundo

“…MICA is a ligand of the activating receptor NKG2D, expressed by NK and T cells. MICA expression is induced in cancer cells favoring their elimination by the…”
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A deeper analysis of the epitope/paratope of PLY-5, a mouse monoclonal antibody which recognises the conserved undecapeptide tryptophan-rich loop (ECTGLAWEWWR) of bacterial cholesterol-dependent cytolysins by González-Menéndez, Pedro, García-Ocaña, Marcos, de los Toyos, Juan R.

“…► An immunoscreening of amino acid substitution analogues in the undecapeptide was performed. ► The second Trp and the Arg residues were identified as…”
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Overexpression of proCOL11A1 as a stromal marker of breast cancer by Fuentes-Martínez, Nelson, García-Pravia, Carmen, García-Ocaña, Marcos, Menéndez-Rodríguez, Primitiva, Del Amo, Jokin, Suárez-Fernández, Laura, Galván, José A, De los Toyos, Juan R, Barneo, Luis

“…Our previous studies demonstrated the expression of procollagen11A1 in fibroblasts of pancreatic cancer desmoplasia and the lack of expression in fibroblasts…”
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Correction: Overexpression of COL11A1 by Cancer-Associated Fibroblasts: Clinical Relevance of a Stromal Marker in Pancreatic Cancer by García-Pravia, Carmen, Galván, José A., Gutiérrez-Corral, Natalia, Solar-García, Lorena, García-Pérez, Eva, García-Ocaña, Marcos, Del Amo-Iribarren, Jokin, Menéndez-Rodríguez, Primitiva, García-García, Juan, de los Toyos, Juan R., Simón-Buela, Laureano, Barneo, Luis

“…A, anti-proCOL11A1 mAb, positive control (inset): cell line A204; B, desmin, positive control (inset): appendix; C, alpha-Smooth Muscle Actin, positive control…”
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innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin O by Carrasco-Marín, Eugenio, Madrazo-Toca, Fidel, de los Toyos, Juan R, Cacho-Alonso, Eva, Tobes, Raquel, Pareja, Eduardo, Paradela, Alberto, Albar, Juan Pablo, Chen, Wei, Gomez-Lopez, Maria Teresa, Alvarez-Dominguez, Carmen

“…Listeriolysin O (LLO) is a thiol-activated cytolysin secreted by Listeria monocytogenes. LLO and phosphatidylinositol phospholipase C are two essential…”
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Characterization of a novel mouse monoclonal antibody, clone 1E8.33, highly specific for human procollagen 11A1, a tumor-associated stromal component by GARCIA-OCANA, Marcos, VAZQUEZ, Fernando, GARCIA-PRAVIA, Carmen, FUENTES-MARTINEZ, Nelson, MENENDEZ-RODRIGUEZ, Primitiva, FRESNO-FORCELLEDO, Florentino, BARNEO-SERRA, Luis, AMO-IRIBARREN, Jokin Del, SIMON-BUELA, Laureano, DE LOS TOYOS, Juan R

“…A novel IgG1, κ mouse monoclonal antibody (clone 1E8.33) to human procollagen 11A1 has been generated. This antibody is poorly mutated, essentially in germ…”
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Mouse monoclonal antibodies to pneumococcal C-polysaccharide backbone show restricted usage of VH-DH-JH gene segments and share the same kappa chain by Fernández-Sánchez, Alba, García-Ocaña, Marcos, de los Toyos, Juan R

“…Abstract The immunization of BALB/c mice with heat-killed cells of Streptococcus mitis SK598 allowed the rescue of mouse monoclonal antibodies (mAbs) reactive…”
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The innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin 0 by CARRASCO-MARIN, Eugenio, MADRAZO-TOCA, Fidel, ALVAREZ-DOMINGUEZ, Carmen, DE LOS TOYOS, Juan R, CACHO-ALONSO, Eva, TOBES, Raquel, PAREJA, Eduardo, PARADELA, Alberto, ALBAR, Juan Pablo, WEI CHEN, GOMEZ-LOPEZ, Maria Teresa

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The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding by Jacobs, T., Cima-Cabal, M.D., Darji, A., Méndez, F.J., Vázquez, F., Jacobs, A.A.C., Shimada, Y., Ohno-Iwashita, Y., Weiss, S., de los Toyos, Juan R.

“…Thiol-activated cytolysins share a conserved hydrophobic, Trp-rich undecapeptide that is suggested to be involved in membrane binding and intercalation. The…”
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