A Case of Congenital Afibrinogenemia and Review of Reported Cases in Japan

A Case of Congenital Afibrinogenemia and Review of Reported Cases in Japan

Congenital afibrinogenemia was first reported in 1920 by Rabe and Salomon. In Japan, since Saito and Asai reported the first case in 1954, 14 cases have been reported so far. The authors found the 10th case and made examinations on clot-ting factors and comparative evaluations on 14 cases reported i...

Full description

Saved in:
Bibliographic Details
Published in:The Tohoku Journal of Experimental Medicine Vol. 96; no. 1; pp. 15 - 35
Main Authors: Yamagata, Shoichi, Mori, Kazuo, Kayaba, Toshio, Hiratsuka, Iwao, Kitamura, Tatsuo, Ishimori, Akira, Takahashi, Osamu, Tozawa, Yoshio, Matsuyama, Keiji, Toyohara, Mochiko
Format: Journal Article
Language:English
Published: Japan Tohoku University Medical Press 01-01-1968
Subjects:
Adolescent
Afibrinogenemia - congenital
Afibrinogenemia - diagnosis
Afibrinogenemia - genetics
Afibrinogenemia - immunology
Age Factors
Blood Coagulation Tests
Calcium - blood
Child
Child, Preschool
Chlorides - blood
Female
Fibrinolysis
Hemorrhage - genetics
Hemorrhagic Disorders - genetics
Humans
Immunoelectrophoresis
Liver Function Tests
Male
Mucoproteins - blood
Pedigree
Potassium - blood
Serum Albumin - analysis
Serum Globulins - analysis
Sodium - blood
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Congenital afibrinogenemia was first reported in 1920 by Rabe and Salomon. In Japan, since Saito and Asai reported the first case in 1954, 14 cases have been reported so far. The authors found the 10th case and made examinations on clot-ting factors and comparative evaluations on 14 cases reported in Japan. Immunological assay for fibrinogen was performed on 5 out of 14 cases. In our own case, fibrinogen was not demonstrated even by Immunological test. Accelerated fibrinolytic activities are considered to be a cause of afibrinogenemia. Our case is the first one in which remarkably decreased fibrinolvtic activities were demonstrated, and this finding is of interest in relation to deficient clotting ability of blood in this disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.96.15