Search Results - "Toyama, M. H"

Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom by Toyama, D.O., Marangoni, S., Diz-Filho, E.B.S., Oliveira, S.C.B., Toyama, M.H.

“…Flavonoids, coumarins and other polyphenolic compounds are powerful antioxidants both in hydrophilic and lipophylic environments with diverse pharmacological…”
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Comparative studies of the anti-leishmanial activity of three Crotalus durissus ssp. venoms by Passero, L. F. D, Tomokane, T. Y, Corbett, C. E. P, Laurenti, M. D, Toyama, M. H

“…In this study, we compared the anti-leishmanial activity of three crotalic venoms (Crotalus durissus terrificus-Cdt, Crotalus durissus cascavella-Cdca, and…”
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Enzymatic and structural characterization of new PLA2 isoform isolated from white venom of Crotalus durissus ruruima by Diz Filho, E.B.S., Marangoni, S., Toyama, D.O., Fagundes, F.H.R., Oliveira, S.C.B., Fonseca, F.V., Calgarotto, A.K., Joazeiro, P.P., Toyama, M.H.

“…This work reports the structural and enzymatic characterization of a new sPLA2 from the white venom of Crotalus durissus ruruima, nominated PLA2A. The…”
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Blood amino acids concentration during insulin induced hypoglycemia in rats: the role of alanine and glutamine in glucose recovery by Garcia, R. F, Gazola, V. A. F. G, Barrena, H. C, Hartmann, E. M, Berti, J, Toyama, M. H, Boschero, A. C, Carneiro, E. M, Manso, F. C, Bazotte, R. B

“…Our purpose was to determine the blood amino acid concentration during insulin induced hypoglycemia (IIH) and examine if the administration of alanine or…”
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Role of phospholipase A2 and tyrosine kinase in Clostridium difficile toxin A-induced disruption of epithelial integrity, histologic inflammatory damage and intestinal secretion by Lima, Aldo A. M., Nascimento, Nilberto R. F., Fang, Guodong D., Yotseff, Peter, Toyama, M. H., Guerrant, Richard L., Fonteles, Manassés C.

“…Clostridium difficile‐associated disease causes diarrhea to fulminant colitis and death. We investigated the role of phospholipase A2 (PLA2) inhibitors,…”
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A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: Biochemical characterization, crystallization, myotoxic and edematogenic activity by Soares, A.M., Rodrigues, V.M., Homsi-Brandeburgo, M.I., Toyama, M.H., Lombardi, F.R., Arni, R.K., Giglio, J.R.

“…Bothrops moojeni snake venom was fractionated on a CM-Sepharose column which was previously equilibrated with 0.05 M ammonium bicarbonate buffer at pH 8.0 and…”
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Renal toxicity of Bothrops moojeni snake venom and its main myotoxins by Barbosa, P.S.F, Havt, A, Facó, P.E.G, Sousa, T.M, Bezerra, I.S.A.M, Fonteles, M.C, Toyama, M.H, Marangoni, S, Novello, J.C, Monteiro, H.S.A

“…Acute renal failure is one the most common systemic complications after snakebite, however, its pathogenesis remains obscure. In this study we evaluated the…”
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Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella by Toyama, M. H., Toyama, D. O., Torres, V. M., Pontes, G. C., Farias, W. R. L., Melo, F. R., Oliveira, S. C. B., Fagundes, F. H. R., Diz Filho, E. B. S., Cavada, B. S.

“…Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus…”
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Circulating leukocyte heat shock protein 70 (HSP70) and oxidative stress markers in rats after a bout of exhaustive exercise by Antunes-Neto, J M F, Toyama, M H, Carneiro, E M, Boschero, A C, Pereira-da-Silva, L, Macedo, D V

“…A novel method to measure oxidative stress resulting from exhaustive exercise in rats is presented. In this new procedure we evaluated the erythrocyte…”
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Purification of a PHA-Like Chitin-binding Protein from Acacia farnesiana Seeds: A Time-dependent Oligomerization Protein by Santi-Gadelha, T, Rocha, B.A.M, Aragão, K.S, Marinho, E.S, Gadelha, C.A.A, Toyama, M.H, Pinto, V.P.T, Nagano, C.S, Delatorre, P

“…A lectin-like protein from the seeds of Acacia farnesiana was isolated from the albumin fraction, characterized, and sequenced by tandem mass spectrometry. The…”
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Structural Basis for Low Catalytic Activity in Lys49 Phospholipases A2A Hypothesis:  The Crystal Structure of Piratoxin II Complexed to Fatty Acid by Lee, Wen-Hwa, da Silva Giotto, Maria Teresa, Marangoni, Sérgio, Toyama, Marcos H, Polikarpov, Igor, Garratt, Richard C

“…Asp49 plays a fundamental role in supporting catalysis by phospholipases A2 by coordinating the calcium ion which aids in the stabilization of the tetrahedral…”
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Neurotoxic and myotoxic actions of crotoxin-like and Crotalus durissus cascavella whole venom in the chick biventer cervicis preparation by Beghini, Daniela G, Rodrigues-Simioni, Léa, Toyama, M.H, Novello, J.C, da Cruz-Höfling, Maria Alice, Marangoni, S

“…Crotoxin from Crotalus durissus cascavella venom was purified by a combination of molecular exclusion chromatography (Superdex 75 column) and HPLC molecular…”
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Purification and biological effects of a C-type lectin isolated from Bothrops moojeni by Barbosa, PSF(Federal University of Ceará Department of Physiology and Pharmacology), Martins, AMC(Federal University of Ceará Department of Clinical and Toxicological Analyses), Toyama, MH(São Paulo State University São Paulo Experimental Coast Campus), Joazeiro, PP(State University of Campinas Institute of Biology Department of Histology), Beriam, LOS(Biological Institute Experimental Center Laboratory of Plant Microbiology), Fonteles, MC(Federal University of Ceará Department of Physiology and Pharmacology), Monteiro, HSA(Federal University of Ceará Department of Physiology and Pharmacology)

“…Snake venom proteins from the C-type lectin family have very distinct biological activities despite their highly conserved primary structure, which is…”
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Isolation and preliminary enzymatic characterization of a novel PLA2 from Crotalus durissus collilineatus venom by Ponce-Soto, L A, Toyama, M H, Hyslop, S, Novello, J C, Marangoni, S

“…A crotoxin homolog was purified from the Crotalus durissus collilineatus venom using molecular exclusion and reverse-phase HPLC. This crotoxin contained one…”
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Structure-function relationship of new crotamine isoform from the Crotalus durissus cascavella by Toyama, O D, Boschero, C A, Martins, A M, Fonteles, C M, Monteiro, S H, Toyama, H M

“…In this work we isolated a novel crotamine like protein from the Crotalus durissus cascavella venom by combination of molecular exclusion and analytical…”
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Structural and functional characterization of basic PLA2 isolated from Crotalus durissus terrificus venom by Oliveira, D G, Toyama, M H, Novello, J C, Beriam, L O S, Marangoni, S

“…The venom of Crotalus durissus terrificus was fractionated by reverse-phase HPLC to obtain crotapotins (F5 and F7) and PLA2 (F15, F16, and F17) of high purity…”
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Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2 by Camargo, E.A., Santana, D.G., Silva, C.I., Teixeira, S.A., Toyama, M.H., Cotrim, C., Landucci, E.C.T., Antunes, E., Muscara, M.N., Costa, S.K.P.

“…Background Nitric oxide is a key signalling molecule in the pathogenesis of inflammation, but its role in acute pancreatitis and related abdominal pain induced…”
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Isolation and characterization of a lectin from Annona muricata seeds by Damico, D C S, Freire, M G M, Gomes, V M, Toyama, M H, Marangoni, S, Novello, J C, Macedo, M L R

“…A lectin with a high affinity for glucose/mannose was isolated from Annona muricata seeds (Annonaceae) by gel filtration chromatography on Sephacryl S-200, ion…”
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Purification and n-terminal sequencing of two presynaptic neurotoxic PLA2, neuwieditoxin-I and neuwieditoxin-II, from Bothrops neuwiedi pauloensis (jararaca pintada) venom by Borja-Oliveira, C. R.(State University of Campinas School of Medical Sciences Department of Pharmacology), Kassab, B. H.(State University of Campinas Institute of Biology Department of Biochemistry), Soares, A. M.(University of São Paulo FCFRP School of Pharmaceutical Sciences), Toyama, M. H.(State University of Campinas Institute of Biology Department of Biochemistry), Giglio, J. R.(University of São Paulo School of Medicine Department of Biochemistry and Immunology), Marangoni, S.(State University of Campinas Institute of Biology Department of Biochemistry), Re, L.(University of Ancona Laboratory of Pharmacology Institute of Experimental and Clinical Sciences), Rodrigues-Simioni, L.(University of São Paulo FCFRP School of Pharmaceutical Sciences)

“…Two presynaptic phospholipases A2 (PLA2), neuwieditoxin-I (NeuTX-I) and neuwieditoxin-II (NeuTX-II), were isolated from the venom of Bothrops neuwiedi…”
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Crystal structure of Bn IV in complex with myristic acid: A Lys49 myotoxic phospholipase A2 from Bothrops neuwiedi venom by Delatorre, P., Rocha, B.A.M., Santi-Gadelha, T., Gadelha, C.A.A., Toyama, M.H., Cavada, B.S.

“…The LYS49-PLA2s myotoxins have attracted attention as models for the induction of myonecrosis by a catalytically independent mechanism of action. Structural…”
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