Search Results - "Toy, Karen"

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations by Bueno, Raphael, Stawiski, Eric W, Goldstein, Leonard D, Durinck, Steffen, De Rienzo, Assunta, Modrusan, Zora, Gnad, Florian, Nguyen, Thong T, Jaiswal, Bijay S, Chirieac, Lucian R, Sciaranghella, Daniele, Dao, Nhien, Gustafson, Corinne E, Munir, Kiara J, Hackney, Jason A, Chaudhuri, Amitabha, Gupta, Ravi, Guillory, Joseph, Toy, Karen, Ha, Connie, Chen, Ying-Jiun, Stinson, Jeremy, Chaudhuri, Subhra, Zhang, Na, Wu, Thomas D, Sugarbaker, David J, de Sauvage, Frederic J, Richards, William G, Seshagiri, Somasekar

“…Raphael Bueno, Eric Stawiski, Somasekar Seshagiri and colleagues present a comprehensive genomic analysis of malignant pleural mesothelioma. They identify four…”
Get full text

ERK inhibition overcomes acquired resistance to MEK inhibitors by Hatzivassiliou, Georgia, Liu, Bonnie, O'Brien, Carol, Spoerke, Jill M, Hoeflich, Klaus P, Haverty, Peter M, Soriano, Robert, Forrest, William F, Heldens, Sherry, Chen, Huifen, Toy, Karen, Ha, Connie, Zhou, Wei, Song, Kyung, Friedman, Lori S, Amler, Lukas C, Hampton, Garret M, Moffat, John, Belvin, Marcia, Lackner, Mark R

“…The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also via mutations in BRAF…”
Get full text

Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases by Zhuang, Guanglei, Yu, Kebing, Jiang, Zhaoshi, Chung, Alicia, Yao, Jenny, Ha, Connie, Toy, Karen, Soriano, Robert, Haley, Benjamin, Blackwood, Elizabeth, Sampath, Deepak, Bais, Carlos, Lill, Jennie R, Ferrara, Napoleone

“…The vascular endothelial growth factor (VEGF) signaling pathway plays a pivotal role in normal development and also represents a major therapeutic target for…”
Get more information

Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer by O'BRIEN, Carol, CAVET, Guy, LACKNER, Mark R, PANDITA, Ajay, XIAOLAN HU, HAYDU, Lauren, MOHAN, Sankar, TOY, Karen, SANCHEZ RIVERS, Celina, MODRUSAN, Zora, AMLER, Lukas C

“…Breast cancer is a heterogeneous disease with distinct molecular subtypes characterized by differential response to targeted and chemotherapeutic agents…”
Get full text

Characterization of intestinal gene expression profiles in Crohn's disease by genome‐wide microarray analysis by Noble, Colin L., Abbas, Alexander R., Lees, Charles W., Cornelius, Jennine, Toy, Karen, Modrusan, Zora, Clark, Hilary F., Arnott, Ian D., Penman, Ian D., Satsangi, Jack, Diehl, Lauri

“…Background: Genome‐wide microarray expression analysis creates a comprehensive picture of gene expression at the cellular level. The aim of this study was to…”
Get full text

Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES by Schall, Thomas J, Bacon, Kevin, Toy, Karen J, Goeddel, David V

“…An important process in the immune response is the migration of different populations of lymphocytes at the proper time to sites of antigenic challenge…”
Get full text

Time course of skeletal muscle repair and gene expression following acute hind limb ischemia in mice by Paoni, Nicholas F, Peale, Franklin, Wang, Fay, Errett-Baroncini, Carol, Steinmetz, Hope, Toy, Karen, Bai, Wei, Williams, P. Mickey, Bunting, Stuart, Gerritsen, Mary E, Powell-Braxton, Lyn

“…1 Department of Cardiovascular Research, South San Francisco, California 94080 2 Department of Pathology, South San Francisco, California 94080 3 Bioanalytical…”
Get full text

In silico data filtering to identify new angiogenesis targets from a large in vitro gene profiling data set by Gerritsen, Mary E, Soriano, Robert, Yang, Suya, Ingle, Gladys, Zlot, Constance, Toy, Karen, Winer, Jane, Draksharapu, Aparna, Peale, Franklin, Wu, Thomas D, Williams, P. Mickey

“…1 Department of Cardiovascular Research 2 Department of Pathology 3 Department of Bioinformatics 4 Department of Molecular Biology Biology, Genentech, South…”
Get full text

VEGF-C mediates cyclic pressure-induced endothelial cell proliferation by Shin, Hainsworth Y, Smith, Michael L, Toy, Karen J, Williams, P. Mickey, Bizios, Rena, Gerritsen, Mary E

“…1 Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 2 Department of Molecular Biology and Department of…”
Get full text

Engineering Actin-Resistant Human DNase I for Treatment of Cystic Fibrosis by Ulmer, Jana S., Herzka, Andrea, Toy, Karen J., Baker, Dana L., Dodge, Anthony H., Sinicropi, Dominick, Shak, Steven, Lazarus, Robert A.

“…Human deoxyribonuclease I (DNase I), an enzyme recently approved for treatment of cystic fibrosis (CF), has been engineered to create two classes of mutants:…”
Get full text

Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes by Durinck, Steffen, Stawiski, Eric W, Pavía-Jiménez, Andrea, Modrusan, Zora, Kapur, Payal, Jaiswal, Bijay S, Zhang, Na, Toffessi-Tcheuyap, Vanina, Nguyen, Thong T, Pahuja, Kanika Bajaj, Chen, Ying-Jiun, Saleem, Sadia, Chaudhuri, Subhra, Heldens, Sherry, Jackson, Marlena, Peña-Llopis, Samuel, Guillory, Joseph, Toy, Karen, Ha, Connie, Harris, Corissa J, Holloman, Eboni, Hill, Haley M, Stinson, Jeremy, Rivers, Celina Sanchez, Janakiraman, Vasantharajan, Wang, Weiru, Kinch, Lisa N, Grishin, Nick V, Haverty, Peter M, Chow, Bernard, Gehring, Julian S, Reeder, Jens, Pau, Gregoire, Wu, Thomas D, Margulis, Vitaly, Lotan, Yair, Sagalowsky, Arthur, Pedrosa, Ivan, de Sauvage, Frederic J, Brugarolas, James, Seshagiri, Somasekar

“…Somasekar Seshagiri, James Brugarolas and colleagues report the mutational landscape of 167 non–clear cell renal cell carcinomas (nccRCCs) from multiple…”
Get full text

Global Gene Expression of Methicillin-resistant Staphylococcus aureus USA300 During Human and Mouse Infection by Date, Shailesh V., Modrusan, Zora, Lawrence, Michael, Morisaki, J. Hiroshi, Toy, Karen, Shah, Ishita M., Kim, Janice, Park, Summer, Xu, Min, Basuino, Li, Chan, Liana, Zeitschel, Deborah, Chambers, Henry F., Tan, Man-Wah, Brown, Eric J., Diep, Binh An, Hazenbos, Wouter L. W.

“…Little is known about the expression of methicillin-resistant Staphylococcus aureus (MRSA) genes during infection conditions. Here, we described the…”
Get full text

Endogenously Expressed IL-13R alpha 2 Attenuates IL-13-Mediated Responses but Does Not Activate Signaling in Human Lung Fibroblasts by Chandriani, Sanjay, DePianto, Daryle J, N'Diaye, Elsa N, Abbas, Alexander R, Jackman, Janet, Bevers, Jack, Ramirez-Carrozzi, Vladimir, Pappu, Rajita, Kauder, Steven E, Toy, Karen, Ha, Connie, Modrusan, Zora, Wu, Lawren C, Collard, Harold R, Wolters, Paul J, Egen, Jackson G, Arron, Joseph R

“…IL-13 can bind to two distinct receptors: a heterodimer of IL-13R alpha 1/IL-4R alpha and IL-13R alpha 2. Whereas IL-13R alpha 1/IL-4R alpha engagement by…”
Get full text

Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts by Chandriani, Sanjay, DePianto, Daryle J, N'Diaye, Elsa N, Abbas, Alexander R, Jackman, Janet, Bevers, 3rd, Jack, Ramirez-Carrozzi, Vladimir, Pappu, Rajita, Kauder, Steven E, Toy, Karen, Ha, Connie, Modrusan, Zora, Wu, Lawren C, Collard, Harold R, Wolters, Paul J, Egen, Jackson G, Arron, Joseph R

“…IL-13 can bind to two distinct receptors: a heterodimer of IL-13Rα1/IL-4Rα and IL-13Rα2. Whereas IL-13Rα1/IL-4Rα engagement by IL-13 leads to the activation of…”
Get full text

A His19 to Ala Mutant of Melanoma Growth-Stimulating Activity Is a Partial Antagonist of the CXCR2 Receptor by Baly, Deborah L, Horuk, Richard, Yansura, Daniel G, Simmons, Laura C, Fairbrother, Wayne J, Kotts, Claire, Wirth, Cindy M, Gillece-Castro, Beth L, Toy, Karen, Hesselgesser, Joseph, Allison, David E

“…Melanoma growth stimulating activity (MGSA) and IL-8 are related chemokines that are potent chemoattractants and activators of neutrophils both in vitro and in…”
Get full text

Evaluation of procedures for amplification of small-size samples for hybridization on microarrays by Klur, Sandra, Toy, Karen, Williams, Mickey P, Certa, Ulrich

“…Various approaches have been developed for the preparation of samples for gene expression monitoring. For Affymetrix chips, a standard protocol is widely used;…”
Get full text

Vascular Endothelial Growth Factor–Induced Genes in Human Umbilical Vein Endothelial Cells: Relative Roles of KDR and Flt-1 Receptors by Yang, Suya, Toy, Karen, Ingle, Gladys, Zlot, Constance, Williams, P Mickey, Fuh, Germaine, Li, Bing, de Vos, Abraham, Gerritsen, Mary E

“…OBJECTIVE—This study evaluated the relative roles of the vascular endothelial growth factor (VEGF) receptors KDR and Flt-1 in the mediation of altered gene…”
Get full text

Breast Self-Examination for Visually Impaired Women by ALBRIGHT, P, TOY, K. W

“…Regularly practiced breast self-examination (BSE) has been demonstrated to be an effective method in the early detection of breast abnormalities. Women are…”
Get full text

Branching Out: A Molecular Fingerprint of Endothelial Differentiation into Tube-Like Structures Generated by Affymetrix Oligonucleotide Arrays by GERRITSEN, MARY E., SORIANO, ROBERT, YANG, SUYA, ZLOT, CONSTANCE, INGLE, GLADYS, TOY, KAREN, WILLIAMS, P. MICKEY

“…ABSTRACT The process of endothelial differentiation into a network of tube‐like structures with patent lumens requires an integrated program of gene…”
Get full text

Branching Out: A Molecular Fingerprint of Endothelial Differentiation into Tube-Like Structures Generated by Affymetrix Oligonucleotide Arrays by GERRITSEN, MARY E., SORIANO, ROBERT, YANG, SUYA, ZLOT, CONSTANCE, INGLE, GLADYS, TOY, KAREN, WILLIAMS, P. MICKEY

“…The process of endothelial differentiation into a network of tube-like structures with patent lumens requires an integrated program of gene expression. To…”
Get full text