Search Results - "Toxicology mechanisms and methods"

The effects of heavy metals on human metabolism by Fu, Zhushan, Xi, Shuhua

“…As technology continues to advance, heavy metals in drinking water have exceeded recommended limits from regulators around the world. The main source of human…”
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In silico and in vivo analysis to identify the antidiabetic activity of beta sitosterol in adipose tissue of high fat diet and sucrose induced type-2 diabetic experimental rats by Ponnulakshmi, R., Shyamaladevi, B., Vijayalakshmi, P., Selvaraj, J.

“…Adipose tissue is the primary site of storage for excess energy as triglyceride and it helps in synthesizing a number of biologically active compounds that…”
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Zinc oxide nanoparticles impacts: cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity by Singh, Sanjiv

“…Zinc oxide (ZnO) is the most commonly used nanoparticles among different nanoparticles. Its applications ranged from personal care products, sensors,…”
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Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development by Cao, Weiya, Yu, Pan, Yang, KePeng, Cao, Dongli

“…Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi, which are widely distributed in nature. Aflatoxin B1 (AFB1) is the most toxic…”
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Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design by Singh, Ajay Vikram, Laux, Peter, Luch, Andreas, Sudrik, Chaitanya, Wiehr, Stefan, Wild, Anna-Maria, Santomauro, Giulia, Bill, Joachim, Sitti, Metin

“…Nanotoxicology and nanosafety has been a topic of intensive research for about more than 20 years. Nearly 10 000 research papers have been published on the…”
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Isoflurane alleviates hypoxia/reoxygenation induced myocardial injury by reducing miR-744 mediated SIRT6 by Chen, Guoqing, Zhang, Faqiang, Wang, Long, Feng, Zeguo

“…The objective of this study was to investigate the role of miR-744 and its target genes in ISO protection against hypoxia/reoxygenation (H/R) induced…”
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Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis by Zhang, Yigang, Tan, Yi, Liu, Shuangchi, Yin, Hongxiang, Duan, Jiakang, Fan, Longfei, Zhao, Xiangyang, Jiang, Bowen

“…Hepatocellular carcinoma (HCC) constitutes a major global health threat due to the high incidence and mortality. Sorafenib is known as the first-line…”
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Doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation by Alhowail, Ahmad H., Bloemer, Jenna, Majrashi, Mohammed, Pinky, Priyanka D., Bhattacharya, Subhrajit, Yongli, Zhang, Bhattacharya, Dwipayan, Eggert, Matthew, Woodie, Lauren, Buabeid, Manal A., Johnson, Nathaniel, Broadwater, Alyssa, Smith, Bruce, Dhanasekaran, Muralikrishnan, Arnold, Robert D., Suppiramaniam, Vishnu

“…Cognitive deficits are commonly reported by patients following treatment with chemotherapeutic agents. Anthracycline-containing chemotherapy regimens are…”
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Quercetin protects cardiomyocytes against doxorubicin-induced toxicity by suppressing oxidative stress and improving mitochondrial function via 14-3-3γ by Chen, Xuanying, Peng, Xiaoping, Luo, Yong, You, Jiegen, Yin, Dong, Xu, Qiang, He, Huan, He, Ming

“…Cardiotoxicity limits the clinical applications of doxorubicin (Dox), which mechanism might be excess generation of intracellular ROS. Quercetin (Que) is a…”
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A review on potential toxicity of dental material and screening their biocompatibility by Shahi, Shahriar, Özcan, Mutlu, Maleki Dizaj, Solmaz, Sharifi, Simin, Al-Haj Husain, Nadin, Eftekhari, Aziz, Ahmadian, Elham

“…Objectives: A wide range of compounds are utilized in dentistry such as dental composites, resins, and implants. The successful clinical use of dental…”
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Urban fine particulate matter (PM2.5) exposure destroys blood-testis barrier (BTB) integrity through excessive ROS-mediated autophagy by Wei, Yi, Cao, Xi-Ning, Tang, Xiang-Liang, Shen, Lian-Ju, Lin, Tao, He, Da-Wei, Wu, Sheng-De, Wei, Guang-Hui

“…Context: Blood-testis barrier (BTB), constituted by tight junctions (TJs), adherens junctions and gap junctions, is important for spermatogenesis. PM2.5 is…”
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Exposure of BPA and its alternatives like BPB, BPF, and BPS impair subsequent reproductive potentials in adult female Sprague Dawley rats by Ijaz, Saman, Ullah, Asad, Shaheen, Ghazala, Jahan, Sarwat

“…Bisphenol A (BPA) and its alternatives are extensively used in household and industrial products. BPA and its alternatives have affinity for estrogen receptors…”
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Relevant essential oil components: a minireview on increasing applications and potential toxicity by Fuentes, Cristina, Fuentes, Ana, Barat, José Manuel, Ruiz, María José

“…Phenolic compounds carvacrol, thymol, eugenol, and vanillin are four of the most thoroughly investigated essential oil components given their relevant…”
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Treatment of oxidative stress, apoptosis, and DNA injury with N-acetylcysteine at simulative pesticide toxicity in fish by Atamanalp, Muhammed, Parlak, Veysel, Özgeriş, Fatma Betül, Çilingir Yeltekin, Aslı, Ucar, Arzu, Keleş, Mevlüt Sait, Alak, Gonca

“…Pesticide toxicities are common in aquatic ecosystems and affects aquatic livings negative. Therefore, it is important to strengthen the antioxidant system in…”
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Toxic effects of chlorine gas and potential treatments: a literature review by Achanta, Satyanarayana, Jordt, Sven-Eric

“…Chlorine gas is one of the highly produced chemicals in the USA and around the world. Chlorine gas has several uses in water purification, sanitation, and…”
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Mitochondria-dependent apoptosis in triptolide-induced hepatotoxicity is associated with the Drp1 activation by Hasnat, Muhammad, Yuan, Ziqiao, Ullah, Aftab, Naveed, Muhammad, Raza, Faisal, Baig, Mirza Muhammad Faran Ashraf, Khan, Asifullah, Xu, Dengqiu, Su, Yuwen, Sun, Linxin, Zhang, Luyong, Jiang, Zhenzhou

“…How triptolide is associated with mitochondrial dysfunction and apoptosis in connection with its hepatotoxicity remains unclear. The objective of our study was…”
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Patho-physiological and toxicological aspects of monosodium glutamate by Chakraborty, Subhankari Prasad

“…Nowadays, the life-line of urban population has been formed by commercial foods due to industrialization, urbanization, and rapid increase in working class…”
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Exosomes derived from bone marrow mesenchymal stem cells reverse epithelial-mesenchymal transition potentially via attenuating Wnt/β-catenin signaling to alleviate silica-induced pulmonary fibrosis by Zhang, Enguo, Geng, Xiao, Shan, Shan, Li, Peng, Li, Shumin, Li, Wentao, Yu, Meili, Peng, Cheng, Wang, Shijun, Shao, Hua, Du, Zhongjun

“…Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present…”
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A comprehensive review of treatments for hydrogen sulfide poisoning: past, present, and future by Santana Maldonado, Cristina, Weir, Abigail, Rumbeiha, Wilson K.

“…Hydrogen sulfide (H 2 S) poisoning remains a significant source of occupational fatalities and is the second most common cause of toxic gas-induced deaths. It…”
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A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences by Mokarizadeh, Aram, Faryabi, Mohammad Reza, Rezvanfar, Mohammad Amin, Abdollahi, Mohammad

“…Nowadays, in many communities, there is a growing concern about possible adverse effects of pesticides on human health. Reports indicate that during…”
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