Search Results - "Toxicology in vitro"

Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro by Hesler, Michelle, Aengenheister, Leonie, Ellinger, Bernhard, Drexel, Roland, Straskraba, Susanne, Jost, Carsten, Wagner, Sylvia, Meier, Florian, von Briesen, Hagen, Büchel, Claudia, Wick, Peter, Buerki-Thurnherr, Tina, Kohl, Yvonne

“…Nanoplastics (NP) and microplastics (MP) accumulate in our environment as a consequence of the massive consumption of plastics. Huge knowledge-gaps exist…”
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Uptake and cellular effects of PE, PP, PET and PVC microplastic particles by Stock, Valerie, Laurisch, Cecilia, Franke, Josephin, Dönmez, Merve Hilal, Voss, Linn, Böhmert, Linda, Braeuning, Albert, Sieg, Holger

“…Humans are exposed to small plastic particles through contaminated food. Such contaminations usually comprise different particulate plastic materials differing…”
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Activation of human nuclear receptors by perfluoroalkylated substances (PFAS) by Behr, Anne-Cathrin, Plinsch, Christin, Braeuning, Albert, Buhrke, Thorsten

“…Perfluoralkylated substances (PFAS) such as perfluorooctanoic acid (PFOA) or perfluorooctanesulfonic acid (PFOS) are used to produce, e.g., surface coatings…”
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Copper induces oxidative stress and apoptosis through mitochondria-mediated pathway in chicken hepatocytes by Yang, Fan, Pei, Ruonan, Zhang, Zhuowei, Liao, Jianzhao, Yu, Wenlan, Qiao, Na, Han, Qingyue, Li, Ying, Hu, Lianmei, Guo, Jianying, Pan, Jiaqiang, Tang, Zhaoxin

“…The aim of this study was to investigate the effects of excessive copper (Cu)-induced cytotoxicity on oxidative stress and mitochondrial apoptosis in chicken…”
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Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway by Jiang, Ting, Cheng, Hui, Su, Jingjing, Wang, Xuncui, Wang, Qiaoxue, Chu, Jun, Li, Qinglin

“…Gastrodin (GAS) is a component of Gastrodia elata Blume, with strong antioxidant activity in neurodegenerative diseases. Ferroptosis is similar to…”
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From genome-wide arrays to tailor-made biomarker readout – Progress towards routine analysis of skin sensitizing chemicals with GARD by Forreryd, Andy, Zeller, Kathrin S., Lindberg, Tim, Johansson, Henrik, Lindstedt, Malin

“…Allergic contact dermatitis (ACD) initiated by chemical sensitizers is an important public health concern. To prevent ACD, it is important to identify chemical…”
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SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study by Cottrez, Françoise, Boitel, Elodie, Ourlin, Jean-Claude, Peiffer, Jean-Luc, Fabre, Isabelle, Henaoui, Imène-Sarah, Mari, Bernard, Vallauri, Ambre, Paquet, Agnes, Barbry, Pascal, Auriault, Claude, Aeby, Pierre, Groux, Hervé

“…The SENS-IS test protocol for the in vitro detection of sensitizers is based on a reconstructed human skin model (Episkin) as the test system and on the…”
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A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier by Yin, Fangchao, Zhu, Yujuan, Zhang, Min, Yu, Hao, Chen, Wenwen, Qin, Jianhua

“…With the commercialization of nanomaterials, environmental exposure to nanoparticles (NPs) has raised great concerns due to the long-term effects to human…”
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In vitro to in vivo extrapolation for high throughput prioritization and decision making by Bell, Shannon M., Chang, Xiaoqing, Wambaugh, John F., Allen, David G., Bartels, Mike, Brouwer, Kim L.R., Casey, Warren M., Choksi, Neepa, Ferguson, Stephen S., Fraczkiewicz, Grazyna, Jarabek, Annie M., Ke, Alice, Lumen, Annie, Lynn, Scott G., Paini, Alicia, Price, Paul S., Ring, Caroline, Simon, Ted W., Sipes, Nisha S., Sprankle, Catherine S., Strickland, Judy, Troutman, John, Wetmore, Barbara A., Kleinstreuer, Nicole C.

“…In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To…”
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Oxidative stress generation of silver nanoparticles in three bacterial genera and its relationship with the antimicrobial activity by Quinteros, M A, Cano Aristizábal, V, Dalmasso, P R, Paraje, M G, Páez, P L

“…Oxidative stress is a condition caused by the high intracellular concentrations of reactive oxygen species (ROS) that includes superoxide anion radicals,…”
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Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study) by Maćczak, Aneta, Cyrkler, Monika, Bukowska, Bożena, Michałowicz, Jaromir

“…Bisphenol A (BPA) and its analogs are widely used in the production of various everyday use products, which leads to a common exposure of humans to these…”
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Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions by Hiemstra, Pieter S., Grootaers, Gwendolynn, van der Does, Anne M., Krul, Cyrille A.M., Kooter, Ingeborg M.

“…The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology…”
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Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway by Yin, Jian, Guo, Jiabin, Zhang, Qiang, Cui, Lan, Zhang, Li, Zhang, Tingfen, Zhao, Jun, Li, Jin, Middleton, Alistair, Carmichael, Paul L., Peng, Shuangqing

“…The usefulness of doxorubicin (DOX), a potent anticancer agent, is limited by its cardiotoxicity. Mitochondria play a central role in DOX-induced…”
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Silver nanoparticles: Significance of physicochemical properties and assay interference on the interpretation of in vitro cytotoxicity studies by Riaz Ahmed, Kausar B., Nagy, Amber M., Brown, Ronald P., Zhang, Qin, Malghan, Subhas G., Goering, Peter L.

“…Silver nanoparticles (AgNPs) have generated a great deal of interest in the research, consumer product, and medical product communities due to their…”
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Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models by Proença, Susana, Escher, Beate I., Fischer, Fabian C., Fisher, Ciarán, Grégoire, Sébastien, Hewitt, Nicky J., Nicol, Beate, Paini, Alicia, Kramer, Nynke I.

“…Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations of in vivo toxic doses because the nominal concentration poorly…”
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PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells by Deng, Xiaobei, Zhang, Fang, Rui, Wei, Long, Fang, Wang, Lijuan, Feng, Zhaohan, Chen, Deliang, Ding, Wenjun

“…•PM2.5 decreases cell viability.•PM2.5 results in lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) generation.•PM2.5 reduces the activity…”
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Epigenetic toxicity of PFOA and GenX in HepG2 cells and their role in lipid metabolism by Wen, Yi, Mirji, Niharika, Irudayaraj, Joseph

“…Perfluorooctanoic acid (PFOA), an extremely persistent perfluoroalkyl substance (PFAS), and 2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy) propanoic acid (GenX),…”
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Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: A quantitative method for oxidative stress assessment of nanoparticle-treated cells by Aranda, A., Sequedo, L., Tolosa, L., Quintas, G., Burello, E., Castell, J.V., Gombau, L.

“…► Nanomaterials interfere with most in vitro fluorimetric screening tests. ► We explore the usefulness of DCFH-DA test to asses NP-induced oxidative stress. ►…”
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Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: Importance of physico-chemical characteristics by Adomako-Bonsu, Amma G., Chan, Sue LF, Pratten, Margaret, Fry, Jeffrey R

“…Persistent accumulation of reactive oxygen species causes cellular oxidative stress which contributes strongly towards the induction and progression of various…”
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Microplastics and nanoplastics: Size, surface and dispersant – What causes the effect? by Stock, Valerie, Böhmert, Linda, Coban, Gülcin, Tyra, Gina, Vollbrecht, Marie-Luise, Voss, Linn, Paul, Maxi B., Braeuning, Albert, Sieg, Holger

“…There is increasing evidence that humans are exposed to microplastic particles through contaminated food. Although suitable analytical methods are still…”
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