Search Results - "Toxicological sciences"

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency by Thomas, Russell S, Bahadori, Tina, Buckley, Timothy J, Cowden, John, Deisenroth, Chad, Dionisio, Kathie L, Frithsen, Jeffrey B, Grulke, Christopher M, Gwinn, Maureen R, Harrill, Joshua A, Higuchi, Mark, Houck, Keith A, Hughes, Michael F, Hunter, E Sidney, Isaacs, Kristin K, Judson, Richard S, Knudsen, Thomas B, Lambert, Jason C, Linnenbrink, Monica, Martin, Todd M, Newton, Seth R, Padilla, Stephanie, Patlewicz, Grace, Paul-Friedman, Katie, Phillips, Katherine A, Richard, Ann M, Sams, Reeder, Shafer, Timothy J, Setzer, R Woodrow, Shah, Imran, Simmons, Jane E, Simmons, Steven O, Singh, Amar, Sobus, Jon R, Strynar, Mark, Swank, Adam, Tornero-Valez, Rogelio, Ulrich, Elin M, Villeneuve, Daniel L, Wambaugh, John F, Wetmore, Barbara A, Williams, Antony J

“…Abstract The U.S. Environmental Protection Agency (EPA) is faced with the challenge of efficiently and credibly evaluating chemical safety often with limited…”
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Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility by Luechtefeld, Thomas, Marsh, Dan, Rowlands, Craig, Hartung, Thomas

“…Earlier we created a chemical hazard database via natural language processing of dossiers submitted to the European Chemical Agency with approximately 10 000…”
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Polycyclic aromatic hydrocarbons: from metabolism to lung cancer by Moorthy, Bhagavatula, Chu, Chun, Carlin, Danielle J

“…Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in lung cancer, a disease with the highest cancer mortality in the United States…”
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Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization by Paul Friedman, Katie, Gagne, Matthew, Loo, Lit-Hsin, Karamertzanis, Panagiotis, Netzeva, Tatiana, Sobanski, Tomasz, Franzosa, Jill A, Richard, Ann M, Lougee, Ryan R, Gissi, Andrea, Lee, Jia-Ying Joey, Angrish, Michelle, Dorne, Jean Lou, Foster, Stiven, Raffaele, Kathleen, Bahadori, Tina, Gwinn, Maureen R, Lambert, Jason, Whelan, Maurice, Rasenberg, Mike, Barton-Maclaren, Tara, Thomas, Russell S

“…Abstract Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the potential to accelerate the pace of human health…”
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Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants by Laskin, Debra L, Malaviya, Rama, Laskin, Jeffrey D

“…Abstract A diverse group of toxicants has been identified that cause injury to the lung including gases (eg, ozone, chlorine), particulates/aerosols (eg,…”
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Making Waves: New Developments in Toxicology With the Zebrafish by Horzmann, Katharine A, Freeman, Jennifer L

“…Abstract The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research. The zebrafish model fills a niche between in vitro models and…”
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Adverse outcome pathway (AOP) development I: strategies and principles by Villeneuve, Daniel L, Crump, Doug, Garcia-Reyero, Natàlia, Hecker, Markus, Hutchinson, Thomas H, LaLone, Carlie A, Landesmann, Brigitte, Lettieri, Teresa, Munn, Sharon, Nepelska, Malgorzata, Ottinger, Mary Ann, Vergauwen, Lucia, Whelan, Maurice

“…An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported,…”
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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study by Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, Houdt, Jos van, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus

“…Abstract Primary human hepatocytes (PHHs) are commonly used for in vitro studies of drug-induced liver injury. However, when cultured as 2D monolayers, PHH…”
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Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity by Upadhyay, Swapna, Palmberg, Lena

“…Abstract Air pollution leads to inhalation of several pulmonary stimulants that includes particulate matter, and gaseous substances contributing significantly…”
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The Impact of Environmental Chemicals on the Gut Microbiome by Chiu, Karen, Warner, Genoa, Nowak, Romana A, Flaws, Jodi A, Mei, Wenyan

“…Abstract Since the surge of microbiome research in the last decade, many studies have provided insight into the causes and consequences of changes in the gut…”
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High-Throughput Transcriptomics Platform for Screening Environmental Chemicals by Harrill, Joshua A, Everett, Logan J, Haggard, Derik E, Sheffield, Thomas, Bundy, Joseph L, Willis, Clinton M, Thomas, Russell S, Shah, Imran, Judson, Richard S

“…Abstract New approach methodologies (NAMs) that efficiently provide information about chemical hazard without using whole animals are needed to accelerate the…”
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Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic by Mendrick, Donna L, Diehl, Anna Mae, Topor, Lisa S, Dietert, Rodney R, Will, Yvonne, La Merrill, Michele A, Bouret, Sebastien, Varma, Vijayalaskshmi, Hastings, Kenneth L, Schug, Thaddeus T, Emeigh Hart, Susan G, Burleson, Florence G

“…Abstract Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic, a Society of Toxicology Contemporary Concepts in Toxicology (CCT) workshop…”
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Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure by Jaeschke, Hartmut, Akakpo, Jephte Y, Umbaugh, David S, Ramachandran, Anup

“…Abstract Liver injury and acute liver failure caused by acetaminophen (APAP, N-acetyl-p-aminophenol, paracetamol) overdose is a significant clinical problem in…”
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Molecular mechanisms of acrolein toxicity: relevance to human disease by Moghe, Akshata, Ghare, Smita, Lamoreau, Bryan, Mohammad, Mohammad, Barve, Shirish, McClain, Craig, Joshi-Barve, Swati

“…Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant and its potential as a serious environmental health threat is…”
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Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias by Blinova, Ksenia, Stohlman, Jayna, Vicente, Jose, Chan, Dulciana, Johannesen, Lars, Hortigon-Vinagre, Maria P, Zamora, Victor, Smith, Godfrey, Crumb, William J, Pang, Li, Lyn-Cook, Beverly, Ross, James, Brock, Mathew, Chvatal, Stacie, Millard, Daniel, Galeotti, Loriano, Stockbridge, Norman, Strauss, David G

“…Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under…”
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Organophosphorus Compounds at 80: Some Old and New Issues by Costa, Lucio G

“…Abstract One of the major classes of pesticides is that of the organophosphates (OPs). Initial developments date back almost 2 centuries but it was only in the…”
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Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor by Judson, Richard S, Magpantay, Felicia Maria, Chickarmane, Vijay, Haskell, Cymra, Tania, Nessy, Taylor, Jean, Xia, Menghang, Huang, Ruili, Rotroff, Daniel M, Filer, Dayne L, Houck, Keith A, Martin, Matthew T, Sipes, Nisha, Richard, Ann M, Mansouri, Kamel, Setzer, R Woodrow, Knudsen, Thomas B, Crofton, Kevin M, Thomas, Russell S

“…We demonstrate a computational network model that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding,…”
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Arsenic Exposure and Toxicology: A Historical Perspective by Hughes, Michael F., Beck, Barbara D., Chen, Yu, Lewis, Ari S., Thomas, David J.

“…The metalloid arsenic is a natural environmental contaminant to which humans are routinely exposed in food, water, air, and soil. Arsenic has a long history of…”
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The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment by Brockmeier, Erica K, Hodges, Geoff, Hutchinson, Thomas H, Butler, Emma, Hecker, Markus, Tollefsen, Knut Erik, Garcia-Reyero, Natalia, Kille, Peter, Becker, Dörthe, Chipman, Kevin, Colbourne, John, Collette, Timothy W, Cossins, Andrew, Cronin, Mark, Graystock, Peter, Gutsell, Steve, Knapen, Dries, Katsiadaki, Ioanna, Lange, Anke, Marshall, Stuart, Owen, Stewart F, Perkins, Edward J, Plaistow, Stewart, Schroeder, Anthony, Taylor, Daisy, Viant, Mark, Ankley, Gerald, Falciani, Francesco

“…In conjunction with the second International Environmental Omics Symposium (iEOS) conference, held at the University of Liverpool (United Kingdom) in September…”
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A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products by Baltazar, Maria T, Cable, Sophie, Carmichael, Paul L, Cubberley, Richard, Cull, Tom, Delagrange, Mona, Dent, Matthew P, Hatherell, Sarah, Houghton, Jade, Kukic, Predrag, Li, Hequn, Lee, Mi-Young, Malcomber, Sophie, Middleton, Alistair M, Moxon, Thomas E, Nathanail, Alexis V, Nicol, Beate, Pendlington, Ruth, Reynolds, Georgia, Reynolds, Joe, White, Andrew, Westmoreland, Carl

“…Abstract Next-Generation Risk Assessment is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates new approach methodologies…”
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