Search Results - "Townsend, Alan J"

Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin by Peklak-Scott, Christina, Smitherman, Pamela K, Townsend, Alan J, Morrow, Charles S

“…Cells expressing elevated levels of allelic variants of human glutathione S-transferase P1 ( GSTP1 ) and/or efflux transporters, MRP1 or MRP2, were used to…”
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Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux by Morrow, Charles S, Peklak-Scott, Christina, Bishwokarma, Bimjhana, Kute, Timothy E, Smitherman, Pamela K, Townsend, Alan J

“…Based upon several previous reports, no consistent relationship between multidrug resistance protein 1 (MRP1, ABCC1) expression and cellular sensitivity to…”
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Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage by Pappa, Aglaia, Chen, Chunhe, Koutalos, Yiannis, Townsend, Alan J, Vasiliou, Vasilis

“…Aldehyde dehydrogenase 3A1 (ALDH3A1) is one of the most abundant proteins found in corneal epithelial cells of mammalian species, with several postulated…”
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Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity by Smitherman, Pamela K, Townsend, Alan J, Kute, Timothy E, Morrow, Charles S

“…Our previous studies have shown that the glutathione S-transferases (GSTs) can operate in synergy with the efflux transporter multidrug resistance protein 1…”
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CANCER CHEMOTHERAPY AND DRUG METABOLISM by Riddick, David S, Lee, Chunja, Ramji, Shairoz, Chinje, Edwin C, Cowen, Rachel L, Williams, Kaye J, Patterson, Adam V, Stratford, Ian J, Morrow, Charles S, Townsend, Alan J, Jounaidi, Youssef, Chen, Chong-Sheng, Su, Ting, Lu, Hong, Schwartz, Pamela S, Waxman, David J

“…Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics and pharmacodynamics of many antineoplastic agents. Metabolism and…”
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Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes by Lok, Hiu Chuen, Rahmanto, Yohan Suryo, Hawkins, Clare L., Kalinowski, Danuta S., Morrow, Charles S., Townsend, Alan J., Ponka, Prem, Richardson, Des R.

“…Nitrogen monoxide (NO) plays a role in the cytotoxic mechanisms of activated macrophages against tumor cells by inducing iron release. We showed that…”
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Lung tumor promotion by curcumin by Dance-Barnes, Stephanie T., Kock, Nancy D., Moore, Joseph E., Lin, Elaine Y., Mosley, Libyadda J., D'Agostino, Ralph B., McCoy, Thomas P., Townsend, Alan J., Miller, Mark Steven

“…Curcumin exhibits anti-inflammatory and antitumor activity and is being tested in clinical trials as a chemopreventive agent for colon cancer. Curcumin's…”
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Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1) by Rudd, Lisa P., Kabler, Sandra L., Morrow, Charles S., Townsend, Alan J.

“…► We asked whether MRP1 + GSTM1 protect against 4-hydroxy-2-nonenal toxicity (HNE). ► MRP1 + GSTM1 sensitized 2.3-fold, not protected, MCF7 cells against HNE…”
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Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells by Paumi, Christian M, Wright, Marcus, Townsend, Alan J, Morrow, Charles S

“…One of the most potent cyclopentenone prostaglandins, 15-deoxy-Delta(12,14)prostaglandin J(2) (15-d-PGJ(2)), has been shown to be cytotoxic in some tumor cells…”
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Nitroalkene Fatty Acids Mediate Activation of Nrf2/ARE-Dependent and PPARγ-Dependent Transcription by Distinct Signaling Pathways and with Significantly Different Potencies by Bates, Darcy J. P, Smitherman, Pamela K, Townsend, Alan J, King, S. Bruce, Morrow, Charles S

“…Naturally occurring nitroalkene fatty acids (NAs) derived from oleic (NO2-OA) and linoleic (NO2-LA) acids mediate a variety of cellular responses. We examined…”
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Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane by Sibhatu, Mebrahtu B., Smitherman, Pamela K., Townsend, Alan J., Morrow, Charles S.

“…A major component of the anticarcinogenic activity of the dietary chemopreventive agent sulforaphane (SFN) is attributed to its ability to induce expression of…”
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Dynamics of Glutathione Conjugation and Conjugate Efflux in Detoxification of the Carcinogen, 4-Nitroquinoline 1-Oxide:  Contributions of Glutathione, Glutathione S-Transferase, and MRP1 by Peklak-Scott, Christina, Townsend, Alan J, Morrow, Charles S

“…4-Nitroquinoline 1-oxide (NQO) is a reactive electrophile with potent cytotoxic as well as genotoxic activities. NQO forms a conjugate, QO-SG, with…”
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Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1 by Kabler, Sandra L., Seidel, Albrecht, Jacob, Juergen, Doehmer, Johannes, Morrow, Charles S., Townsend, Alan J.

“…Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via…”
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Noncatalytic Interactions between Glutathione S-Transferases and Nitroalkene Fatty Acids Modulate Nitroalkene-Mediated Activation of Peroxisomal Proliferator-Activated Receptor γ by Bates, Darcy J. P, Lively, Mark O, Gorczynski, Michael J, King, S. Bruce, Townsend, Alan J, Morrow, Charles S

“…The naturally occurring nitroalkenes, nitrolinoleic (NO2-LA) and nitrooleic (NO2-OA) acids, are among the most potent endogenous ligand activators of…”
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DIFFERENTIAL SENSITIVITY TO LUNG TUMORIGENESIS FOLLOWING TRANSPLACENTAL EXPOSURE OF MICE TO POLYCYCLIC HYDROCARBONS, HETEROCYCLIC AMINES, AND LUNG TUMOR PROMOTERS by Mark Steven Miller, Kiersten M. Gressani, Sandra Leone-Kabler, Alan J. Townsend, Alvin M. Malkinson, M. Gerard O'Sullivan

“…Research conducted by this laboratory over the past decade has demonstrated the high susceptibility of the fetus to lung tumor formation following in utero…”
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Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1 by Kushman, Mary E., Kabler, Sandra L., Fleming, Melissa H., Ravoori, Srivani, Gupta, Ramesh C., Doehmer, Johannes, Morrow, Charles S., Townsend, Alan J.

“…Transgenic cell lines were constructed to study dynamic competition between activation versus detoxification of benzo[a]pyrene (B[a]P) and its metabolites…”
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Protective Efficacy of hGSTM1-1 against B[a]P and (+)- or (−)-B[a]P-7,8-Dihydrodiol Cytotoxicity, Mutagenicity, and Macromolecular Adducts in V79 Cells Coexpressing hCYP1A1 by Kushman, Mary E., Kabler, Sandra L., Ahmad, Sarfaraz, Doehmer, Johannes, Morrow, Charles S., Townsend, Alan J.

“…Transgenic cell lines were constructed to study the dynamics of competition between activation versus detoxification of benzo[a]pyrene (B[a]P) or…”
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Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression by Ahmad, Sarfaraz, Kabler, Sandra L., Rudd, Lisa, Amin, Shantu, Doehmer, Johannes, Morrow, Charles S., Townsend, Alan J.

“…The environmental carcinogen 5-methylchrysene (5MC) can be activated to mutagenic metabolites by several isozymes of cytochrome P-450 (CYP). The resulting…”
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Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1 by Kushman, Mary E, Kabler, Sandra L, Ahmad, Sarfaraz, Doehmer, Johannes, Morrow, Charles S, Townsend, Alan J

“…We have used V79MZ hamster lung fibroblasts stably transfected with human cytochrome P450-1A1 (hCYP1A1; cell line designated V79MZh1A1) or P450-1B1 (hCYP1B1;…”
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Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins by DIAH, Sri K, SMITHERMAN, Pamela K, ALDRIDGE, Jerry, VOLK, Erin L, SCHNEIDER, Erasmus, TOWNSEND, Alan J, MORROW, Charles S

“…We examined the role of multidrug resistance protein (MRP) 1 (ABCC1) in the emergence of mitoxantrone (MX) cross-resistance in a MCF7 breast cancer cell line…”
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