Search Results - "Townley, W"

Sent to Destroy: The Ubiquitin Proteasome System Regulates Cell Signaling and Protein Quality Control in Cardiovascular Development and Disease by Willis, Monte S, Townley-Tilson, W H. Davin, Kang, Eunice Y, Homeister, Jonathon W, Patterson, Cam

“…The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integral to the development of the cardiovascular system and cardiovascular…”
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MicroRNAs 1, 133, and 206: Critical factors of skeletal and cardiac muscle development, function, and disease by Townley-Tilson, W.H. Davin, Callis, Thomas E., Wang, DaZhi

“…microRNAs (miRNAs) are a class of highly conserved small non-coding RNAs that negatively regulate gene expression post-transcriptionally. miRNAs are known to…”
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The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2 by Townley-Tilson, W H Davin, Wu, Yaxu, Ferguson, 3rd, James E, Patterson, Cam

“…Vascularization of the placenta is a critical developmental process that ensures fetal viability. Although the vascular health of the placenta affects both…”
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Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice by Kayashima, Yukako, Townley-Tilson, W H Davin, Vora, Neeta L, Boggess, Kim, Homeister, Jonathon W, Maeda-Smithies, Nobuyo, Li, Feng

“…Obesity is a risk factor for preeclampsia. We investigated how obesity influences preeclampsia in mice lacking ankyrin-repeat-and-SOCS-box-containing-protein 4…”
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Nutritional Strategies against Diabetic Nephropathy: Insights from Animal Studies and Human Trials by Zhou, Jiayi, Franceschini, Nora, Townley-Tilson, W H Davin, Maeda-Smithies, Nobuyo

“…Diabetic nephropathy (DN), defined as continuously elevated urinary albumin and a diminished estimated glomerular filtration rate, is a serious complication of…”
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The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis by Wang, Yuye, Ssengonzi, Rebecca, Townley-Tilson, W H Davin, Kayashima, Yukako, Maeda-Smithies, Nobuyo, Li, Feng

“…Preeclampsia is a complex pregnancy-related hypertensive disorder which poses significant risks for both maternal and fetal health. Preeclampsia affects 5-8%…”
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Head and neck cancer surgery during the coronavirus pandemic: a single-institution experience by Jeannon, J-P, Simo, R, Oakley, R, Townley, W, Orfaniotis, G, Fry, A, Arora, A, Taylor, C, Ahmad, I

“…The coronavirus disease 2019 pandemic resulted in the cessation of elective surgery. The continued provision of complex head and neck cancer surgery was…”
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Dupuytren's contracture unfolded by Townley, W A, Baker, R, Sheppard, N, Grobbelaar, A O

“…Summary points Dupuytren's disease is a disabling condition common in elderly men Treatment is often unnecessary, but regular follow-up is needed to detect…”
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LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation by Mao, Hua, Lockyer, Pamela, Townley-Tilson, W.H Davin, Xie, Liang, Pi, Xinchun

“…OBJECTIVE—We recently demonstrated that low-density lipoprotein receptor–related protein 1 (LRP1) is required for cardiovascular development in zebrafish…”
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Critical assessment of the anterolateral thigh flap donor site by Townley, W.A, Royston, E.C, Karmiris, N, Crick, A, Dunn, R.L.R

“…Summary Background The free anterolateral thigh flap (ALT) is now used as a ‘workhorse flap’. The donor site morbidity is thought to be minimal, although most…”
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PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban by Xie, Liang, Pi, Xinchun, Townley-Tilson, W H Davin, Li, Na, Wehrens, Xander H T, Entman, Mark L, Taffet, George E, Mishra, Ashutosh, Peng, Junmin, Schisler, Jonathan C, Meissner, Gerhard, Patterson, Cam

“…Ischemic heart disease is the leading cause of heart failure. Both clinical trials and experimental animal studies demonstrate that chronic hypoxia can induce…”
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Orbital exenteration and reconstruction in a tertiary UK institution: a 5-year experience by Fleming, J. C., Morley, I., Malik, M., Orfaniotis, G., Daniel, C., Townley, W. A., Jeannon, J. P.

“…Orbital exenteration is a radical oncological surgery that is usually indicated for advanced primary orbital tumors or invasion from local malignancy. We…”
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De-epithelialised patch: a simple method to monitor free flaps intraorally by Zakai, D, Townley, W, Cascarini, L

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Costs and coding—Free-flap reconstruction in lower-limb trauma by Townley, W.A, Urbanska, C, Dunn, R.L.R, Khan, U

“…Abstract Introduction The provision of a complex lower-limb trauma service has significant resource implications. This financial burden is not recognised by…”
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The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease by Townley-Tilson, W. H. Davin, Xie, Liang, Pi, Xinchun

“…Ischemic heart disease is the leading cause of death worldwide. Oxygen-sensing proteins are critical components of the physiological response to hypoxia and…”
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Reconstruction of sarcoma defects following pre-operative radiation: Free tissue transfer is safe and reliable by Townley, W.A, Mah, E, O'Neill, A.C, Wunder, J.S, Ferguson, P.C, Zhong, T, Hofer, S.O.P

“…Summary Background Neoadjuvant radiotherapy followed by surgical resection and soft tissue reconstruction provides the best possibility of achieving superior…”
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Fixed reference points in mapping medial sural artery perforator location by Pease, N.L, Ong, J, Townley, W.A

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Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation by Emmons, Jillian, Townley-Tilson, W H Davin, Deleault, Kristen M, Skinner, Stephen J, Gross, Robert H, Whitfield, Michael L, Brooks, Seth A

“…Dendritic cells provide a critical link between innate and adaptive immunity and are essential to prime a naive T-cell response. The transition from immature…”
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A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research by Kockel, Lutz, Huq, Lutfi M, Ayyar, Anika, Herold, Emma, MacAlpine, Elle, Logan, Madeline, Savvides, Christina, Kim, Grace E S, Chen, Jiapei, Clark, Theresa, Duong, Trang, Fazel-Rezai, Vahid, Havey, Deanna, Han, Samuel, Jagadeesan, Ravi, Kim, Eun Soo Jackie, Lee, Diane, Lombardo, Kaelina, Piyale, Ida, Shi, Hansen, Stahr, Lydia, Tung, Dana, Tayvah, Uriel, Wang, Flora, Wang, Ja-Hon, Xiao, Sarah, Topper, Sydni M, Park, Sangbin, Rotondo, Cheryl, Rankin, Anne E, Chisholm, Townley W, Kim, Seung K

“…Novel binary gene expression tools like the LexA-LexAop system could powerfully enhance studies of metabolism, development, and neurobiology in Drosophila…”
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Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia by Li, Feng, Fushima, Tomofumi, Oyanagi, Gen, Townley-Tilson, H. W. Davin, Sato, Emiko, Nakada, Hironobu, Oe, Yuji, Hagaman, John R., Wilder, Jennifer, Li, Manyu, Sekimoto, Akiyo, Saigusa, Daisuke, Sato, Hiroshi, Ito, Sadayoshi, Jennette, J. Charles, Maeda, Nobuyo, Karumanchi, S. Ananth, Smithies, Oliver, Takahashi, Nobuyuki

“…Preeclampsia (PE) complicates ∼5% of human pregnancies and is one of the leading causes of pregnancy-related maternal deaths. The only definitive treatment,…”
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