Search Results - "Townley, Brittany A."

The debranching enzyme Dbr1 regulates lariat turnover and intron splicing by Buerer, Luke, Clark, Nathaniel E., Welch, Anastasia, Duan, Chaorui, Taggart, Allison J., Townley, Brittany A., Wang, Jing, Soemedi, Rachel, Rong, Stephen, Lin, Chien-Ling, Zeng, Yi, Katolik, Adam, Staley, Jonathan P., Damha, Masad J., Mosammaparast, Nima, Fairbrother, William G.

“…The majority of genic transcription is intronic. Introns are removed by splicing as branched lariat RNAs which require rapid recycling. The branch site is…”
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Immunoaffinity Purification of Epitope-Tagged DNA Repair Complexes from Human Cells by Townley, Brittany A, Soll, Jennifer M, Mosammaparast, Nima

“…Immunoaffinity purification allows for the purification of epitope-tagged proteins and their associated multisubunit complexes from mammalian cells. Subsequent…”
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Intersections between transcription-coupled repair and alkylation damage reversal by Brickner, Joshua R., Townley, Brittany A., Mosammaparast, Nima

“…The response to DNA damage intersects with many other physiological processes in the cell, such as DNA replication, chromatin remodeling, and the cell cycle…”
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Aberrant RNA methylation triggers recruitment of an alkylation repair complex by Tsao, Ning, Brickner, Joshua R., Rodell, Rebecca, Ganguly, Adit, Wood, Matthew, Oyeniran, Clement, Ahmad, Tanveer, Sun, Hua, Bacolla, Albino, Zhang, Lisheng, Lukinović, Valentina, Soll, Jennifer M., Townley, Brittany A., Casanova, Alexandre G., Tainer, John A., He, Chuan, Vindigni, Alessandro, Reynoird, Nicolas, Mosammaparast, Nima

“…Central to genotoxic responses is their ability to sense highly specific signals to activate the appropriate repair response. We previously reported that the…”
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A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy by Townley, Brittany A., Buerer, Luke, Tsao, Ning, Bacolla, Albino, Mansoori, Fadhel, Rusanov, Timur, Clark, Nathanial, Goodarzi, Negar, Schmidt, Nicolas, Srivatsan, Sridhar Nonavinkere, Sun, Hua, Sample, Reilly A., Brickner, Joshua R., McDonald, Drew, Tsai, Miaw-Sheue, Walter, Matthew J., Wozniak, David F., Holehouse, Alex S., Pena, Vladimir, Tainer, John A., Fairbrother, William G., Mosammaparast, Nima

“…The pre-mRNA life cycle requires intron processing; yet, how intron-processing defects influence splicing and gene expression is unclear. Here, we find that…”
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