Search Results - "Towbin, Benjamin D."

Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery by Towbin, Benjamin D., González-Aguilera, Cristina, Sack, Ragna, Gaidatzis, Dimos, Kalck, Véronique, Meister, Peter, Askjaer, Peter, Gasser, Susan M.

“…The factors that sequester transcriptionally repressed heterochromatin at the nuclear periphery are currently unknown. In a genome-wide RNAi screen, we found…”
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Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos by Gonzalez-Sandoval, Adriana, Towbin, Benjamin D., Kalck, Veronique, Cabianca, Daphne S., Gaidatzis, Dimos, Hauer, Michael H., Geng, Liqing, Wang, Li, Yang, Teddy, Wang, Xinghao, Zhao, Kehao, Gasser, Susan M.

“…Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree of compaction and transcriptional status. In Caenorhabditis…”
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Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans by Stojanovski, Klement, Großhans, Helge, Towbin, Benjamin D.

“…Animals increase by orders of magnitude in volume during development. Therefore, small variations in growth rates among individuals could amplify to a large…”
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Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery by Dion, Vincent, Kalck, Véronique, Horigome, Chihiro, Towbin, Benjamin D., Gasser, Susan M.

“…Chromatin mobility is thought to facilitate homology search during homologous recombination and to shift damage either towards or away from specialized repair…”
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Optimality and sub-optimality in a bacterial growth law by Towbin, Benjamin D., Korem, Yael, Bren, Anat, Doron, Shany, Sorek, Rotem, Alon, Uri

“…Organisms adjust their gene expression to improve fitness in diverse environments. But finding the optimal expression in each environment presents a challenge…”
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Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP by Bren, Anat, Park, Junyoung O., Towbin, Benjamin D., Dekel, Erez, Rabinowitz, Joshua D., Alon, Uri

“…In most conditions, glucose is the best carbon source for E. coli: it provides faster growth than other sugars and is consumed first in sugar mixtures. Here we…”
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Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1 by Stojanovski, Klement, Gheorghe, Ioana, Lenart, Peter, Lanjuin, Anne, Mair, William B., Towbin, Benjamin D.

“…Even slight imbalance between the growth rate of different organs can accumulate to a large deviation from their appropriate size during development. Here, we…”
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Hierarchy of non-glucose sugars in Escherichia coli by Aidelberg, Guy, Towbin, Benjamin D, Rothschild, Daphna, Dekel, Erez, Bren, Anat, Alon, Uri

“…Understanding how cells make decisions, and why they make the decisions they make, is of fundamental interest in systems biology. To address this, we study the…”
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Mechanisms of heterochromatin subnuclear localization by Towbin, Benjamin D., Gonzalez-Sandoval, Adriana, Gasser, Susan M.

“…•A new role for histone modifications in determining the nuclear organization of heterochromatin.•Many aspects are conserved from worms to man.•A model for…”
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The spatial dynamics of tissue-specific promoters during C. elegans development by Meister, Peter, Towbin, Benjamin D, Pike, Brietta L, Ponti, Aaron, Gasser, Susan M

“…To understand whether the spatial organization of the genome reflects the cell's differentiated state, we examined whether genes assume specific subnuclear…”
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Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans by Smith, Hannah J, Lanjuin, Anne, Sharma, Arpit, Prabhakar, Aditi, Nowak, Ewelina, Stine, Peter G, Sehgal, Rohan, Stojanovski, Klement, Towbin, Benjamin D, Mair, William B

“…mTORC1 (mechanistic target of rapamycin complex 1) is a metabolic sensor that promotes growth when nutrients are abundant. Ubiquitous inhibition of mTORC1…”
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An EDMD Mutation in C. elegans Lamin Blocks Muscle-Specific Gene Relocation and Compromises Muscle Integrity by Mattout, Anna, Pike, Brietta L., Towbin, Benjamin D., Bank, Erin M., Gonzalez-Sandoval, Adriana, Stadler, Michael B., Meister, Peter, Gruenbaum, Yosef, Gasser, Susan M.

“…In worms, as in other organisms, many tissue-specific promoters are sequestered at the nuclear periphery when repressed and shift inward when activated. It has…”
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The interplay between metabolic stochasticity and cAMP-CRP regulation in single E. coli cells by Wehrens, Martijn, Krah, Laurens H.J., Towbin, Benjamin D., Hermsen, Rutger, Tans, Sander J.

“…The inherent stochasticity of metabolism raises a critical question for understanding homeostasis: are cellular processes regulated in response to internal…”
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The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery by Ferreira, Helder C, Towbin, Benjamin D, Jegou, Thibaud, Gasser, Susan M

“…Telomeres are specialized protein-DNA structures that protect chromosome ends. In budding yeast, telomeres form clusters at the nuclear periphery. By imaging…”
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The formation and sequestration of heterochromatin during development by Gonzalez‐Sandoval, Adriana, Towbin, Benjamin D., Gasser, Susan M.

“…Chromatin is not randomly positioned in the nucleus, but is distributed in subdomains based on its degree of compaction and transcriptional status. Recent…”
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A Bacterial Growth Law out of Steady State by Korem Kohanim, Yael, Levi, Dikla, Jona, Ghil, Towbin, Benjamin D., Bren, Anat, Alon, Uri

“…Bacterial growth follows simple laws in constant conditions. However, bacteria in nature often face fluctuating environments. We therefore ask whether there…”
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The nuclear envelope — a scaffold for silencing? by Towbin, Benjamin D, Meister, Peter, Gasser, Susan M

“…An increasing number of studies indicate that chromosomes are spatially organized in the interphase nucleus and that some genes tend to occupy characteristic…”
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Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis by Al-Refaie, Nada, Padovani, Francesco, Hornung, Johanna, Pudelko, Lorenz, Binando, Francesca, del Carmen Fabregat, Andrea, Zhao, Qiuxia, Towbin, Benjamin D., Cenik, Elif Sarinay, Stroustrup, Nicholas, Padeken, Jan, Schmoller, Kurt M., Cabianca, Daphne S.

“…Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom, yet how it impacts…”
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formation and sequestration of heterochromatin during development: Delivered on 7 September 2012 at the 37th FEBS Congress in Sevilla, Spain by Gonzalez‐Sandoval, Adriana, Towbin, Benjamin D, Gasser, Susan M

“…Chromatin is not randomly positioned in the nucleus, but is distributed in subdomains based on its degree of compaction and transcriptional status. Recent…”
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Increased mobility of double-strand breaks requires Mecl, Rad9 and the homologous recombination machinery by Dion, Vincent, Kalck, Veronique, Horigome, Chihiro, Towbin, Benjamin D, Gasser, Susan M

“…Chromatin mobility is thought to facilitate homology search during homologous recombination and to shift damage either towards or away from specialized repair…”
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