Regulation of tyrosine hydroxylase activity in the rat hypothalamus with gamma-aminobutyric acid

It is established that GABA interacts with tyrosine hydroxylase through the allosteric site which is not identical to sites of tyrosine, DOPA, pterin cofactor, dopamine binding. This interaction is very significant in the GABA influence on the regulation of the tyrosine hydroxylase activity by presy...

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Bibliographic Details
Published in:	Ukrainskij biohimičeskij žurnal Vol. 61; no. 2; p. 38
Main Authors:	Tovmasian, A Kh, Simonian, S Z, Kazarian, B A, Mineeva, M F
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-03-1989
Subjects:	Allosteric Regulation Animals gamma-Aminobutyric Acid - metabolism Hypothalamus - enzymology Rats Tyrosine 3-Monooxygenase - metabolism
Online Access:	Get more information
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Summary:	It is established that GABA interacts with tyrosine hydroxylase through the allosteric site which is not identical to sites of tyrosine, DOPA, pterin cofactor, dopamine binding. This interaction is very significant in the GABA influence on the regulation of the tyrosine hydroxylase activity by presynaptic receptors. GABA is supposed to be able to cause dissociation of oligomeric forms of tyrosine hydroxylase.
ISSN:	0201-8470