Search Results - "Tovar, Adelaide"

Baseline and innate immune response characterization of a Zfp30 knockout mouse strain by Laudermilk, Lucas T., Tovar, Adelaide, Homstad, Alison K., Thomas, Joseph M., McFadden, Kathryn M., Tune, Miriya K., Cowley, Dale O., Mock, Jason R., Ideraabdullah, Folami, Kelada, Samir N. P.

“…Airway neutrophilia is correlated with disease severity in a number of chronic and acute pulmonary diseases, and dysregulation of neutrophil chemotaxis can…”
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Ozone‐induced changes in the murine lung extracellular vesicle small RNA landscape by Smith, Gregory J., Tovar, Adelaide, Kanke, Matt, Wang, Yong, Deshane, Jessy S., Sethupathy, Praveen, Kelada, Samir N. P.

“…Inhalation exposure to ozone (O3) causes adverse respiratory health effects that result from airway inflammation, a complex response mediated in part by…”
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300-OR: A Modular Massively Parallel Reporter Assay Uncovers Context-Specific Activity of Diabetes-Associated Regulatory Elements by TOVAR, ADELAIDE

“…Recent genome-wide association studies (GWAS) have identified hundreds of signals associated with type 2 diabetes (T2D) , most (∼90%) of which are found in…”
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1468-P: Massively Parallel Reporter Assay Reveals Position-, Promoter-, and Strand-Dependent Effects in Islet TSSs Overlapping Type 2 Diabetes GWAS Loci by Bose, Maya L, Tovar, Adelaide, Varshney, Arushi, Parker, Stephen, Kitzman, Jacob, Kyono, Yasuhiro

“…Introduction & Objective: Massively parallel reporter assays (MPRAs) are an increasingly popular method of assessing the sequence-dependent activity of…”
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278-OR: Single-Nucleus Multiomics Profiling across 49 Individuals of Hispanic Ancestry Reveals Cell-Specific Skeletal Muscle Insulin-Responsive Gene Regulatory Signatures by Li, Benjamin, Varshney, Arushi, Tovar, Adelaide, Manickam, Nandini, Orchard, Peter, Defronzo, Ralph A, Norton, Luke, Parker, Stephen

“…More than 1,000 genome-wide association study (GWAS) signals have been identified for type 2 diabetes (T2D) and related metabolic traits. 90% of these map to…”
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2013-LB: Population-Scale Skeletal Muscle Single-Nucleus Multiomic Profiling Reveals Extensive Context-Specific Genetic Regulation by Varshney, Arushi, Manickam, Nandini, Orchard, Peter, Tovar, Adelaide, Zhang, Zhenhao, Feng, Fan, Lakka, Timo A, Laakso, Markku, Tuomilehto, Jaakko, Mohlke, Karen L, Kitzman, Jacob, Koistinen, Heikki A, Liu, Jie, Boehnke, Michael, Collins, Francis S, Scott, Laura, Parker, Stephen C

“…Skeletal muscle, the largest human organ by weight, is relevant to several polygenic metabolic traits and diseases including type 2 diabetes (T2D). Identifying…”
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Dissecting Respiratory Responses to Ozone Exposure with Genetics and Genomics by Tovar, Adelaide

“…Tropospheric ozone is a ubiquitous air pollutant associated with a range of adverse health consequences, including considerable cardiorespiratory morbidity and…”
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Transcriptional Profiling of the Murine Airway Response to Acute Ozone Exposure by Tovar, Adelaide, Smith, Gregory J, Thomas, Joseph M, Crouse, Wesley L, Harkema, Jack R, Kelada, Samir N P

“…Abstract Ambient ozone (O3) exposure has serious consequences on respiratory health, including airway inflammation and injury. Decades of research have yielded…”
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A Murine Model of Ozone-induced Nonatopic Asthma from the Collaborative Cross by Smith, Gregory J, Tovar, Adelaide, McFadden, Kathryn, Moran, Timothy P, Wagner, James G, Harkema, Jack R, Kelada, Samir N P

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A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice by Tovar, Adelaide, Smith, Gregory J, Nalesnik, Morgan B, Thomas, Joseph M, McFadden, Kathryn M, Harkema, Jack R, Kelada, Samir N P

“…Ozone (O )-induced respiratory toxicity varies considerably within the human population and across inbred mouse strains, indicative of gene-environment…”
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Integrative analysis reveals mouse strain-dependent responses to acute ozone exposure associated with airway macrophage transcriptional activity by Tovar, Adelaide, Crouse, Wesley L, Smith, Gregory J, Thomas, Joseph M, Keith, Benjamin P, McFadden, Kathryn M, Moran, Timothy P, Furey, Terrence S, Kelada, Samir N P

“…Acute ozone (O ) exposure is associated with multiple adverse cardiorespiratory outcomes, the severity of which varies across individuals in human populations…”
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