Search Results - "Touyz, R."

Hope for resistant hypertension through BrigHTN and PRECISION by Touyz, R. M., Harrison, D. G.

“…An estimated 10–15% of individuals with hypertension are resistant to available antihypertensive therapies. Findings from two new clinical trials — BrigHTN and…”
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Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis by Skiba, D S, Nosalski, R, Mikolajczyk, T P, Siedlinski, M, Rios, F J, Montezano, A C, Jawien, J, Olszanecki, R, Korbut, R, Czesnikiewicz‐Guzik, M, Touyz, R M, Guzik, T J

“…Background and Purpose Inflammation plays a key role in atherosclerosis. The protective role of angiotensin 1–7 (Ang‐(1–7)) in vascular pathologies suggested…”
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Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy by Sedeek, M, Callera, G, Montezano, A, Gutsol, A, Heitz, F, Szyndralewiez, C, Page, P, Kennedy, C R J, Burns, K D, Touyz, R M, Hébert, R L

“…Molecular mechanisms underlying renal complications of diabetes remain unclear. We tested whether renal NADPH oxidase (Nox) 4 contributes to increased reactive…”
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Role of magnesium in the pathogenesis of hypertension by Touyz, R.M.

“…Human essential hypertension is a complex, multifactorial, quantitative trait under polygenic control. Although the exact etiology is unknown, the fundamental…”
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Reactive oxygen species and angiotensin II signaling in vascular cells -- implications in cardiovascular disease by Touyz, R M

“…Diseases such as hypertension, atherosclerosis, hyperlipidemia, and diabetes are associated with vascular functional and structural changes including…”
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Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe−/− mice by Di Marco, E., Gray, S. P., Chew, P., Koulis, C., Ziegler, A., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., Slattery, R., Jandeleit-Dahm, K. A.

“…Aims/hypothesis Enhanced vascular inflammation, immune cell infiltration and elevated production of reactive oxygen species (ROS) contribute significantly to…”
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Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats by Harrison, D G, Bader, M, Lerman, L O, Fink, G, Karumanchi, S A, Reckelhoff, J F, Sequeira-Lopez, M L S, Touyz, R M

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c-Src Induces Phosphorylation and Translocation of p47phox: Role in Superoxide Generation by Angiotensin II in Human Vascular Smooth Muscle Cells by Touyz, R M, Yao, G, Schiffrin, E L

“…OBJECTIVES—The aim of this study was to determine molecular mechanisms whereby c-Src regulates angiotensin II (Ang II)-mediated NAD(P)H oxidase-derived ·O2 in…”
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Aldosterone and Angiotensin II Synergistically Stimulate Migration in Vascular Smooth Muscle Cells Through c-Src–Regulated Redox-Sensitive RhoA Pathways by Montezano, A C, Callera, G E, Yogi, A, He, Y, Tostes, R C, He, G, Schiffrin, E L, Touyz, R M

“…OBJECTIVE—Synergistic interactions between aldosterone (Aldo) and angiotensin II (Ang II) have been implicated in vascular inflammation, fibrosis, and…”
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Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension: What Is the Clinical Significance? by Touyz, Rhian M

“…Metabolism of oxygen by cells generates potentially deleterious reactive oxygen species (ROS). Under normal conditions the rate and magnitude of oxidant…”
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p47phox Associates With the Cytoskeleton Through Cortactin in Human Vascular Smooth Muscle Cells: Role in NAD(P)H Oxidase Regulation by Angiotensin II by Touyz, R M, Yao, G, Quinn, M T, Pagano, P J, Schiffrin, E L

“…OBJECTIVE—We tested the hypothesis that p47phox associates with the actin cytoskeleton, enabling site-directed activation of NAD(P)H oxidase, and assessed…”
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Vascular Endothelial Growth Factor (VEGF) inhibitors as a novel strategy in the treatment of Arterio Venous Malformations (AVMs): time for a clinical study by Koppel, D, Touyz, R

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Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation by Bruder-Nascimento, T, Chinnasamy, P, Riascos-Bernal, D.F, Cau, S.B, Callera, G.E, Touyz, R.M, Tostes, R.C, Sibinga, N.E.S

“…Abstract Fat1 is an atypical cadherin that controls vascular smooth muscle cell (VSMC) proliferation and migration. Nicotinamide adenine dinucleotide phosphate…”
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Assessment of Caveolae/Lipid Rafts in Isolated Cells by Callera, G E, Bruder-Nascimento, Thiago, Touyz, R M

“…This chapter outlines protocols to evaluate protein localization, recruitment or phosphorylation levels in cholesterol/sphingolipids-enriched cell membrane…”
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Antioxidant Effects of Vitamins C and E Are Associated With Altered Activation of Vascular NADPH Oxidase and Superoxide Dismutase in Stroke-Prone SHR by Chen, Xin, Touyz, Rhian M, Park, Jeong Bae, Schiffrin, Ernesto L

“…Ascorbic acid (vitamin C) and α-tocopherol (vitamin E) have antioxidant properties that could improve redox-sensitive vascular changes associated with…”
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Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan by SCHIFFRIN, E. L, JEONG BAE PARK, INTENGAN, H. D, TOUYZ, R. M

“…Structural and functional alterations of the vasculature may contribute to complications of hypertension. Because angiotensin II may be pivotal in some of…”
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Reactive oxygen species in vascular biology: implications in hypertension by Touyz, R M, Schiffrin, E L

“…Reactive oxygen species (ROS), including superoxide (*O2-), hydrogen peroxide (H2O2), and hydroxyl anion (OH-), and reactive nitrogen species, such as nitric…”
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Recent advances in angiotensin II signaling by Touyz, R M, Berry, C

“…Angiotensin II (Ang II) is a multifunctional hormone that influences the function of cardiovascular cells through a complex series of intracellular signaling…”
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Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms by Kuneš, J, Hojná, S, Mráziková, L, Montezano, A, Touyz, RM, Maletínská, L

“…The worldwide increase in the incidence of obesity and cardiovascular and neurodegenerative diseases, e.g. Alzheimer's disease, is related to many factors,…”
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Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide by Berry, C, Touyz, R, Dominiczak, A F, Webb, R C, Johns, D G

“…Angiotensin II (ANG II) is a pleiotropic vasoactive peptide that binds to two distinct receptors: the ANG II type 1 (AT(1)) and type 2 (AT(2)) receptors…”
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