Search Results - "Touw, Ivo P."

G-CSF and its receptor in myeloid malignancy by Beekman, Renée, Touw, Ivo P.

“…Granulocyte colony-stimulating factor (G-CSF) has been used in the clinic for more than 2 decades to treat congenital and acquired neutropenias and to reduce…”
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia by Olofsen, Patricia A, Touw, Ivo P

“…Somatic mutations are found in approximately 10% of patients with acute myeloid leukemia (AML), but are more common in secondary forms of myelodysplastic…”
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Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts by Horos, Rastislav, IJspeert, Hanna, Pospisilova, Dagmar, Sendtner, Regine, Andrieu-Soler, Charlotte, Taskesen, Erdogan, Nieradka, Andrzej, Cmejla, Radek, Sendtner, Michael, Touw, Ivo P., von Lindern, Marieke

“…Diamond-Blackfan anemia (DBA) is associated with developmental defects and profound anemia. Mutations in genes encoding a ribosomal protein of the small (eg,…”
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Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia by Beekman, Renée, Valkhof, Marijke G., Sanders, Mathijs A., van Strien, Paulette M.H., Haanstra, Jurgen R., Broeders, Lianne, Geertsma-Kleinekoort, Wendy M., Veerman, Anjo J.P., Valk, Peter J.M., Verhaak, Roel G., Löwenberg, Bob, Touw, Ivo P.

“…Severe congenital neutropenia (SCN) is a BM failure syndrome with a high risk of progression to acute myeloid leukemia (AML). The underlying genetic changes…”
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Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system by Feyen, Jacqueline, Ping, Zhen, Chen, Lanpeng, van Dijk, Claire, van Tienhoven, Tim V. D., van Strien, Paulina M. H., Hoogenboezem, Remco M., Wevers, Michiel J. W., Sanders, Mathijs A., Touw, Ivo P., Raaijmakers, Marc H. G. P.

“…Innate and adaptive immune cells participate in the homeostatic regulation of hematopoietic stem cells (HSCs). Here, we interrogate the contribution of myeloid…”
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia by Olofsen, Patricia A, Touw, Ivo P

“…Somatic RUNX1 mutations are found in approximately 10% of patients with de novo acute myeloid leukemia (AML), but are more common in secondary forms of…”
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MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1–regulated pathways in mice by Meenhuis, Annemarie, van Veelen, Peter A., de Looper, Hans, van Boxtel, Nicole, van den Berge, Iris J., Sun, Su M., Taskesen, Erdogan, Stern, Patrick, de Ru, Arnoud H., van Adrichem, Arjan J., Demmers, Jeroen, Jongen-Lavrencic, Mojca, Löwenberg, Bob, Touw, Ivo P., Sharp, Phillip A., Erkeland, Stefan J.

“…MicroRNAs (miRNAs) are pivotal for regulation of hematopoiesis but their critical targets remain largely unknown. Here, we show that ectopic expression of…”
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Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders by Touw, Ivo P, van de Geijn, Gert-Jan M

“…Granulocyte colony-stimulating factor (G-CSF) is the major hematopoietic cytokine involved in the control of neutrophil production and thus serves as a…”
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Severe congenital neutropenia and chronic neutrophilic leukemia: an intriguing molecular connection unveiled by oncogenic mutations in CSF3R by Touw, Ivo P, Beekman, Renée

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Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes by Zambetti, Noemi A, Bindels, Eric M J, Van Strien, Paulina M H, Valkhof, Marijke G, Adisty, Maria N, Hoogenboezem, Remco M, Sanders, Mathijs A, Rommens, Johanna M, Touw, Ivo P, Raaijmakers, Marc H G P

“…Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with…”
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Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3 by Dicken, Joseph, Mildner, Alexander, Leshkowitz, Dena, Touw, Ivo P, Hantisteanu, Shay, Jung, Steffen, Groner, Yoram

“…Classical dendritic cells (cDC) are specialized antigen-presenting cells mediating immunity and tolerance. cDC cell-lineage decisions are largely controlled by…”
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The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between the European Hematology Association and the EuNet‐INNOCHRON COST Action by Fioredda, Francesca, Skokowa, Julia, Tamary, Hannah, Spanoudakis, Michail, Farruggia, Piero, Almeida, Antonio, Guardo, Daniela, Höglund, Petter, Newburger, Peter E., Palmblad, Jan, Touw, Ivo P., Zeidler, Cornelia, Warren, Alan J., Dale, David C., Welte, Karl, Dufour, Carlo, Papadaki, Helen A.

“…Neutropenia, as an isolated blood cell deficiency, is a feature of a wide spectrum of acquired or congenital, benign or premalignant disorders with a…”
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Congenital neutropenia: disease models guiding new treatment strategies by Touw, Ivo P.

“…Myeloid diseases are often characterized by a disturbed regulation of myeloid cell proliferation, survival, and maturation. This may either result in a severe…”
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Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation by Sanz, Arturo, Ungureanu, Daniela, Pekkala, Tuija, Ruijtenbeek, Rob, Touw, Ivo P, Hilhorst, Riet, Silvennoinen, Olli

“…Janus kinase 2 (JAK2) initiates signaling from several cytokine receptors and is required for biological responses such as erythropoiesis. JAK2 activity is…”
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Prevalence of a new auto-activating colony stimulating factor 3 receptor mutation (CSF3R-T595I) in acute myeloid leukemia and severe congenital neutropenia by Beekman, Renée, Valkhof, Marijke, van Strien, Paulette, Valk, Peter J M, Touw, Ivo P

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The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia by Palande, Karishma K, Beekman, Renee, van der Meeren, Lotte E, Beverloo, H Berna, Valk, Peter J M, Touw, Ivo P

“…The antioxidant peroxiredoxin (PRDX) protein family comprises 6 members, which are implicated in a variety of cellular responses, including growth factor…”
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The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains by Sanz Sanz, Arturo, Niranjan, Yashavanthi, Hammarén, Henrik, Ungureanu, Daniela, Ruijtenbeek, Rob, Touw, Ivo P., Silvennoinen, Olli, Hilhorst, Riet

“…JAK2 tyrosine kinase regulates many cellular functions. Its activity is controlled by the pseudokinase (JH2) domain by still poorly understood mechanisms. The…”
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B-cell tumor development in Tet2-deficient mice by Mouly, Enguerran, Ghamlouch, Hussein, Della-Valle, Veronique, Scourzic, Laurianne, Quivoron, Cyril, Roos-Weil, Damien, Pawlikowska, Patrycja, Saada, Véronique, Diop, M'Boyba K., Lopez, Cécile K., Fontenay, Michaela, Dessen, Philippe, Touw, Ivo P., Mercher, Thomas, Aoufouchi, Said, Bernard, Olivier A.

“…The TET2 gene encodes an α-ketoglutarate–dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA…”
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Retroviral Insertion Mutagenesis in Mice as a Comparative Oncogenomics Tool to Identify Disease Genes in Human Leukemia by Touw, Ivo P, Erkeland, Stefan J

“…Retroviral insertion mutagenesis has recently received much attention because of its adverse effects in the application of retroviral vector-based gene…”
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The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor by Meenhuis, Annemarie, Verwijmeren, Carola, Roovers, Onno, Touw, Ivo P

“…Ubiquitination of the CSF3R [CSF3 (colony-stimulating factor 3) receptor] occurs after activated CSF3Rs are internalized and reside in early endosomes. CSF3R…”
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