Search Results - "Touw, D"

Pharmacogenetics: From Bench to Byte- An Update of Guidelines by Swen, JJ, Nijenhuis, M, Boer, A, Grandia, L, Maitland‐van der Zee, AH, Mulder, H, Rongen, GAPJM, Schaik, RHN, Schalekamp, T, Touw, DJ, Weide, J, Wilffert, B, Deneer, VHM, Guchelaar, H‐J

“…Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch…”
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Saliva for Model Informed Precision Dosing by Touw, D J

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Optimization of Fluconazole Dosing for the Prevention and Treatment of Invasive Candidiasis Based on the Pharmacokinetics of Fluconazole in Critically Ill Patients by Boonstra, J M, Märtson, A G, Sandaradura, I, Kosterink, J G W, van der Werf, T S, Marriott, D J E, Zijlstra, J G, Touw, D J, Alffenaar, J W C

“…The efficacy of fluconazole is related to the area under the plasma concentration-time curve (AUC) over the MIC of the microorganism. Physiological changes in…”
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Pharmacokinetics and Pharmacodynamics of Ruxolitinib: A Review by Appeldoorn, T. Y. J., Munnink, T. H. Oude, Morsink, L. M., Hooge, M. N. Lub-de, Touw, D. J.

“…Background and Objective Ruxolitinib is a tyrosine kinase inhibitor targeting the Janus kinase (JAK) and signal transducer and activator of transcription…”
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Paediatric formulations for the treatment of drug resistant TB: closing the gaps by Alffenaar, J. W. C., Marais, B. J., Touw, D. J.

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Pharmacokinetic/pharmacodynamic analysis of weight- and height-scaled tobramycin dosage regimens for patients with cystic fibrosis by Alghanem, S S, Touw, D J, Thomson, A H

“…To determine the outcomes of weight- and height-based tobramycin dosing regimens for patients with cystic fibrosis (CF). A simulated dataset of 5000 patients…”
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Pharmacogenetics: From Bench to Byte by Swen, JJ, Wilting, I, Goede, AL, Grandia, L, Mulder, H, Touw, DJ, Boer, A, Conemans, JMH, Egberts, TCG, Klungel, OH, Koopmans, R, Weide, J, Wilffert, B, Guchelaar, H‐J, Deneer, VHM

“…Despite initial enthusiasm,1,2,3 the use of pharmacogenetics has remained limited to investigation in only a few clinical fields such as oncology and…”
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Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review by van Gendt, J., Emaus, R., Visschedijk, M. C., Touw, D. J., Bouwknegt, D. G., de Leeuw, K., Prins, J. R., Malik, P., Mian, Paola

“…Background and Objective Although little information is available on the pharmacokinetics (PK) of monoclonal antibodies (mAbs) during pregnancy, multiple mAbs…”
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Pharmacokinetic Properties of Micafungin in Critically Ill Patients Diagnosed with Invasive Candidiasis by Boonstra, J M, van der Elst, K C, Veringa, A, Jongedijk, E M, Brüggemann, R J, Koster, R A, Kampinga, G A, Kosterink, J G, van der Werf, T S, Zijlstra, J G, Touw, D J, Alffenaar, J W C

“…The estimated attributable mortality rate for invasive candidiasis (IC) in the intensive care unit (ICU) setting varies from 30 to 40%. Physiological changes…”
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Reply to Van Daele et al., "Fluconazole Underexposure in Critically Ill Patients: a Matter of Using the Right Targets?" by Märtson, A-G, Boonstra, J M, Sandaradura, I, Kosterink, J G W, van der Werf, T S, Marriott, D J E, Zijlstra, J G, Touw, D J, Alffenaar, J W C

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Pharmacokinetics and Target Attainment of Antimicrobial Drugs Throughout Pregnancy: Part I—Penicillins by Hesse, M. R., Prins, J. R., Hooge, M. N. Lub-de, Winter, H. L. J., Kosterink, J. G. W., Touw, D. J., Mian, Paola

“…Background and Objective Pharmacokinetics (PK) are severely altered in pregnant women due to changes in volume of distribution (Vd) and/or drug clearance (CL),…”
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Population Pharmacokinetic Model and Optimal Sampling Strategies for Micafungin in Critically Ill Patients Diagnosed with Invasive Candidiasis by Boonstra, J M, van der Elst, K C, Zijlstra, J G, van der Werf, T S, Alffenaar, J W C, Touw, D J

“…bloodstream infections are associated with high attributable mortality, where early initiation of adequate antifungal therapy is important to increase survival…”
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Pharmacy compounded pilocarpine: An adequate solution to overcome shortage of pilogel® discs for sweat testing in patients with cystic fibrosis by Mian, P., Maurer, J.M., Touw, D.J., Vos, M.J., Rottier, B.L.

“…•A pharmacy compounded pilocarpine HCL solution was developed and validated for use in CF diagnosis in respond to shortage of pilogel® discs.•These data show a…”
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Linezolid-Induced Thrombocytopenia in Patients with Renal Impairment: A Case Series, Review and Dose Advice by Laarhuis, S. R. E., Kerskes, C. H. M., Nijziel, M. R., van Wensen, R. J. A., Touw, D. J.

“…Background and Objective Oral linezolid is often used as alternative therapy for intravenous vancomycin. According to the current guidelines, no dose…”
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The Pharmacokinetics and Target Attainment of Antimicrobial Drugs Throughout Pregnancy: Part III Non-penicillin and Non-cephalosporin Drugs by Groen, F., Prins, J. R., Hooge, M. N. Lub-de, Winter, H. L. J., Kosterink, J. G. W., Touw, D. J., Mian, P.

“…Introduction Understanding the pharmacokinetics (PK) of antimicrobial drugs in pregnant women is crucial to provide effective and safe treatment. This study is…”
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Test of neural inertia in humans during general anaesthesia by Kuizenga, M H, Colin, P J, Reyntjens, K M E M, Touw, D J, Nalbat, H, Knotnerus, F H, Vereecke, H E M, Struys, M M R F

“…Neural inertia is defined as the tendency of the central nervous system to resist transitions between arousal states. This phenomenon has been observed in mice…”
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Variability in perfusion conditions and set-up parameters used in ex vivo human placenta models: A literature review by Glättli, S.C., Elzinga, F.A., van der Bijl, W., Leuvenink, H.G.D., Prins, J.R., van Goor, H., Gordijn, S.J., Olinga, P., Touw, D.J., Mian, P.

“…The ex vivo human placenta perfusion model has proven to be clinically relevant to study transfer- and fetal exposure of various drugs. Although the method has…”
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Immunoassay Analysis of Kanamycin in Serum Using the Tobramycin Kit by Dijkstra, J A, Voerman, A J, Greijdanus, B, Touw, D J, Alffenaar, J W C

“…Kanamycin is one of the aminoglycosides used in the treatment of multidrug-resistant tuberculosis. Blood concentrations of kanamycin are predictive for the…”
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A comparison of the acid-inhibitory effects of esomeprazole and rabeprazole in relation to pharmacokinetics and CYP2C19 polymorphism by Hunfeld, N. G., Touw, D. J., Mathot, R. A., van Schaik, R. H., Kuipers, E. J.

“…Summary Background Esomeprazole and rabeprazole are metabolised in the liver by means of the CYP2C19 enzyme, which has several functional genetic…”
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Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus by Doring, G, Conway, SP, Heijerman, HG, Hodson, ME, Hoiby, N, Smyth, A, Touw, DJ

“…Cystic fibrosis (CF) is the most common lethal hereditary disorder with autosomal recessive heredity in caucasians. The majority of CF patients suffer from…”
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