Search Results - "Toussi, S S"

Infections in Children and Adolescents With Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Treated With Tumor Necrosis Factor-  Inhibitors: Systematic Review of the Literature by Toussi, S. S., Pan, N., Walters, H. M., Walsh, T. J.

“…Tumor necrosis factor alpha (TNF-...) inhibitors are increasingly administered to children and adolescents with juvenile idiopathic arthritis (JIA) and…”
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An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes by Pinato, D J, Tan, T M, Toussi, S T K, Ramachandran, R, Martin, N, Meeran, K, Ngo, N, Dina, R, Sharma, R

“…Background: Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are heterogeneous with respect to biological behaviour and prognosis. As angiogenesis is a…”
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Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations by Pinato, D J, Ramachandran, R, Toussi, S T K, Vergine, M, Ngo, N, Sharma, R, Lloyd, T, Meeran, K, Palazzo, F, Martin, N, Khoo, B, Dina, R, Tan, T M

“…Background: There are no reliable markers of malignancy in phaeochromocytomas (PCC) and paragangliomas (PGL). We investigated the relevance of the mammalian…”
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The impact of disease activity and tumour necrosis factor‐α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis by Walters, H. M., Pan, N., Lehman, T. J. A., Adams, A., Kalliolias, G. D., Zhu, Y. S., Santiago, F., Nguyen, J., Sitaras, L., Cunningham‐Rundles, S., Walsh, T. J., Toussi, S. S.

“…Summary The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with…”
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Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir by Singh, Ravi Shankar P., Toussi, Sima S., Hackman, Frances, Chan, Phylinda L., Rao, Rohit, Allen, Richard, Van Eyck, Lien, Pawlak, Sylvester, Kadar, Eugene P., Clark, Frances, Shi, Haihong, Anderson, Annaliesa S., Binks, Michael, Menon, Sandeep, Nucci, Gianluca, Bergman, Arthur

“…Coronavirus disease 2019 (COVID‐19) is a continued leading cause of hospitalization and death. Safe, efficacious COVID‐19 antivirals are needed urgently…”
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Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID‐19, in Subjects With Renal Impairment by Toussi, Sima S., Neutel, Joel Michael, Navarro, Jesus, Preston, Richard Alfred, Shi, Haihong, Kavetska, Olga, LaBadie, Robert R., Binks, Michael, Chan, Phylinda L.S., Demers, Neil, Corrigan, Brian, Damle, Bharat

“…Nirmatrelvir coadministered with ritonavir is highly efficacious in reducing the risk of coronavirus disease 2019 (COVID‐19) adverse outcomes among patients at…”
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Infections in Children and Adolescents With Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Treated With Tumor Necrosis Factor–α Inhibitors: Systematic Review of the Literature by Toussi, Sima S., Pan, Nancy, Walters, Heather M., Walsh, Thomas J.

“…Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly administered to children and adolescents with juvenile idiopathic arthritis (JIA) and pediatric…”
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Therapeutics for COVID-19 by Toussi, Sima S., Hammond, Jennifer L., Gerstenberger, Brian S., Anderson, Annaliesa S.

“…Vaccines and monoclonal antibody treatments to prevent severe coronavirus disease 2019 (COVID-19) illness were available within a year of the pandemic being…”
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Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development by Singh, Ravi Shankar P., Walker, Gregory S., Kadar, Eugene P., Cox, Loretta M., Eng, Heather, Sharma, Raman, Bergman, Arthur J., Van Eyck, Lien, Hackman, Frances, Toussi, Sima S., Kalgutkar, Amit S., Obach, R. Scott

“…Typically human absorption, distribution, metabolism, and excretion (ADME) studies are executed using radiolabeled (e.g., carbon‐14) material, the synthesis of…”
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Effect of Hepatic Impairment on the Pharmacokinetics of Nirmatrelvir/Ritonavir, the First Oral Protease Inhibitor for the Treatment of COVID‐19 by Singh, Ravi Shankar P., LaBadie, Robert R., Toussi, Sima S., Shi, Haihong, Berg, Jolene Kay, Neutel, Joel M., Aggarwal, Sudeepta

“…Nirmatrelvir, a novel, potent, orally bioavailable severe acute respiratory syndrome coronavirus 2 main protease inhibitor, coadministered with ritonavir for…”
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Prevalence of Hepatitis B and C Virus Infections in Children Infected with HIV by Toussi, Sima Shelly, Abadi, Jacobo, Rosenberg, Michael, Levanon, Daniela

“…We evaluated the prevalence and transmission mode of hepatitis B and C in an inner-city, pediatric cohort of human immunodeficiency virus (HIV)—infected…”
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Measuring Media Use in College Students With and Without Human Immunodeficiency Virus Infection by Dunn-Navarra, Ann-Margaret, PhD, CPNP-BC, Toussi, Sima S., MD, Cohn, Elizabeth, DNSc, RN, Neu, Natalie, MD, MPH, Larson, Elaine L., PhD, RN, FAAN, CIC

“…Abstract Introduction Media applications have shown promise for health education. The aims of this study were to develop and evaluate a media survey measure…”
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The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration by Cheruvu, Narayan, van Duijn, Esther, Spigt, Pieter A., Barbu, Ioana M., Toussi, Sima S., Schildknegt, Klaas, Jones, Rhys M., Obach, R. Scott

“…The metabolism of lufotrelvir, a novel phosphate prodrug of PF-00835231 for the treatment of COVID-19, was evaluated in healthy human volunteers and clinical…”
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On-line Voltage and Power Flow Contingencies Ranking Using Enhanced Radial Basis Function Neural Network and Kernel Principal Component Analysis by Javan, D. Seyed, Rajabi Mashhadi, H., Toussi, S. Ashkezari, Rouhani, M.

“…Timely and accurate assessment of voltage and power flow security is necessary to detect post-contingency problems in order to prevent a large-scale blackout…”
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NASPGHAN Clinical Report: Surveillance, Diagnosis, and Prevention of Infectious Diseases in Pediatric Patients With Inflammatory Bowel Disease Receiving Tumor Necrosis Factor-α Inhibitors by Ardura, Monica I, Toussi, Sima S, Siegel, Jane D, Lu, Ying, Bousvaros, Athos, Crandall, Wallace

“…ABSTRACTChildren and adolescents with inflammatory bowel disease (IBD) receiving therapy with tumor necrosis factor α inhibitors (anti-TNFα) pose a unique…”
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Safety, Tolerability, and Pharmacokinetics of Intravenous Doses of PF‐07304814, a Phosphate Prodrug Protease Inhibitor for the Treatment of SARS‐CoV‐2, in Healthy Adult Participants by Zhu, Tong, Pawlak, Sylvester, Toussi, Sima S., Hackman, Frances, Thompson, Kimberly, Song, Wei, Salageanu, Joanne, Winter, Erica, Shi, Haihong, Winton, Jennifer, Binks, Michael

“…Studies on targeted antivirals for treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the cause of the ongoing pandemic, are limited…”
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Procalcitonin Differs in Children With Infection and Children With Disease Flares in Juvenile Idiopathic Arthritis by Trachtman, Rebecca, Murray, Elizabeth, Wang, Cindy M., Szymonifka, Jackie, Toussi, Sima S., Walters, Heather, Nellis, Marianne E., Onel, Karen B., Mandl, Lisa A.

“…BACKGROUND/OBJECTIVEPatients with juvenile idiopathic arthritis (JIA) often present with signs and symptoms suggestive of serious bacterial infection (SBI)…”
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(1→3)-β-d-Glucan in Cerebrospinal Fluid as a Biomarker for Candida and Aspergillus Infections of the Central Nervous System in Pediatric Patients by Salvatore, Christine M., Chen, Tempe K., Toussi, Sima S., DeLaMora, Patricia, Petraitiene, Ruta, Finkelman, Malcolm A., Walsh, Thomas J.

“…Background Fungal infections of the central nervous system (FICNS) are important causes of morbidity and mortality among immunocompromised pediatric patients…”
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Blastomycosis During Pregnancy: A Case Report and Review of the Literature by Baker, Thomas, Patel, Ami, Halteh, Pierre, Toussi, Sima S, DeLaMora, Patricia, Lipner, Shari, Schuetz, Audrey N, Hartman, Barry

“…Abstract The diagnosis of blastomycosis during pregnancy is rare, but can carry significant clinical questions for both the infected mother and developing…”
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Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Intravenous Infusions of PF-07304814 (Lufotrelvir) in Participants Hospitalized With COVID-19 by Robinson, Philip, Toussi, Sima S, Aggarwal, Sudeepta, Bergman, Arthur, Zhu, Tong, Hackman, Frances, Sathish, Jean G, Updyke, Lawrence, Loudon, Peter, Krishna, Ganesh, Clevenbergh, Philippe, Hernandez-Mora, Miguel Gorgolas, Cisneros Herreros, Jose Miguel, Albertson, Timothy E, Dougan, Michael, Thacker, Amber, Baniecki, Mary Lynn, Soares, Holly, Whitlock, Mark, Nucci, Gianluca, Menon, Sandeep, Anderson, Annaliesa S, Binks, Michael

“…Abstract Background An urgent need remains for antiviral therapies to treat patients hospitalized with COVID-19. PF-07304814—the prodrug (lufotrelvir) and its…”
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