Search Results - "Tousignant, J D"

Binding and uptake of cationic lipid:pDNA complexes by polarized airway epithelial cells by Chu, Q, Tousignant, J D, Fang, S, Jiang, C, Chen, L H, Cheng, S H, Scheule, R K, Eastman, S J

“…To better understand the barriers associated with cationic lipid-mediated gene transfer to polarized epithelial cells, Fischer rat thyroid (FRT) cells and…”
Get more information

Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice by Tousignant, J D, Gates, A L, Ingram, L A, Johnson, C L, Nietupski, J B, Cheng, S H, Eastman, S J, Scheule, R K

“…A major limitation associated with systemic administration of cationic lipid:plasmid DNA (pDNA) complexes is the vector toxicity at the doses necessary to…”
Get more information

Reduced Inflammatory Response to Plasmid DNA Vectors by Elimination and Inhibition of Immunostimulatory CpG Motifs by Yew, Nelson S., Zhao, Hongmei, Wu, I-Huan, Song, Antonius, Tousignant, Jennifer D., Przybylska, Malgorzata, Cheng, Seng H.

“…An inflammatory response is invariably associated with administration of gene transfer complexes composed of cationic lipids and plasmid DNA (pDNA). In the…”
Get full text

DNA sequences in cationic lipid:pDNA-mediated systemic toxicities by Tousignant, Jennifer D, Zhao, Hongmei, Yew, Nelson S, Cheng, Seng H, Eastman, Simon J, Scheule, Ronald K

“…Systemic delivery of synthetic gene transfer vectors such as cationic lipid:plasmid DNA (pDNA) complexes elicits a range of acute physiologic responses, which…”
Get more information

Partial correction of the α-galactosidase A deficiency and reduction of glycolipid storage in Fabry mice using synthetic vectors by Przybylska, Malgorzata, Wu, I-Huan, Zhao, Hongmei, Ziegler, Robin J., Tousignant, Jennifer D., Desnick, Robert J., Scheule, Ronald K., Cheng, Seng H., Yew, Nelson S.

“…Background Fabry disease is a recessive, X‐linked disorder caused by a deficiency of the lysosomal enzyme α‐galactosidase A, leading to an accumulation of the…”
Get full text

A concentrated and stable aerosol formulation of cationic lipid:DNA complexes giving high-level gene expression in mouse lung by Eastman, S J, Lukason, M J, Tousignant, J D, Murray, H, Lane, M D, St George, J A, Akita, G Y, Cherry, M, Cheng, S H, Scheule, R K

“…Advances in gene therapy vectors and techniques hold promise for treatment of many inherited and acquired diseases. For lung indications, especially those…”
Get more information

Optimization of formulations and conditions for the aerosol delivery of functional cationic lipid:DNA complexes by Eastman, S J, Tousignant, J D, Lukason, M J, Murray, H, Siegel, C S, Constantino, P, Harris, D J, Cheng, S H, Scheule, R K

“…We have examined several variables inherent in aerosolizing cationic lipid:DNA complexes using a jet nebulizer and thereby have optimized the delivery of…”
Get more information

Aerosolization of cationic lipid:pDNA complexes--in vitro optimization of nebulizer parameters for human clinical studies by Eastman, S J, Tousignant, J D, Lukason, M J, Chu, Q, Cheng, S H, Scheule, R K

“…Previously, we have described the optimization of the aerosol delivery of a nonviral gene therapy vector to the lungs of rodents (Eastman et al., 1997b)…”
Get more information

CpG-Depleted Plasmid DNA Vectors with Enhanced Safety and Long-Term Gene Expression in Vivo by Yew, Nelson S., Zhao, Hongmei, Przybylska, Malgorzata, Wu, I-Huan, Tousignant, Jennifer D., Scheule, Ronald K., Cheng, Seng H.

“…Systemic delivery of cationic lipid–plasmid DNA (pDNA) complexes induces an acute inflammatory response with adverse hematologic changes and liver damage…”
Get full text