Association of central serous chorioretinopathy with single nucleotide polymorphisms in complement factor H gene in Iranian population

Objectives To investigate the association of two different single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene with central serous chorioretinopathy (CSCR) in the Iranian population. Methods This is a case-control study with 95 participants in each group who were stratified...

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Published in:	Eye (London) Vol. 36; no. 5; pp. 1061 - 1065
Main Authors:	Karkhaneh, Reza, Toufighi, Mohsen, Amirfiroozy, Akbar, Ahmad-Raji, Aliasghar, Ahmadzadeh, Oveis, Mahdavi, Alborz, Naderan, Morteza
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-05-2022 Nature Publishing Group
Subjects:	38/23 631/208/2489/144 692/699/3161/3175 Case-Control Studies Central Serous Chorioretinopathy - genetics Complement factor H Complement Factor H - genetics Gene polymorphism H gene Humans Iran Laboratory Medicine Leukocytes Medicine Medicine & Public Health Ophthalmology Patients Peripheral blood Pharmaceutical Sciences/Technology Polymorphism Polymorphism, Single Nucleotide Single-nucleotide polymorphism Surgery Surgical Oncology Iran
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Summary:	Objectives To investigate the association of two different single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene with central serous chorioretinopathy (CSCR) in the Iranian population. Methods This is a case-control study with 95 participants in each group who were stratified according to their various ethnical variations. Primers for rs1329428 and rs3753394 polymorphisms were synthesized. DNA was extracted from peripheral blood leukocytes and underwent PCR and high-resolution melt analysis. Results The frequency of tt, ct, and cc genotypes for rs1329428 polymorphism was 22 (26.5%), 46 (55.4%), and 15 (18.1%) in acute CSCR and 5 (41.7%), 5 (41.7%), and 2 (16.7%) in chronic CSCR respectively with no significant difference between case and control groups. The frequency of tt, ct, and cc genotypes for rs3753394 polymorphism was 31 (37.3%), 14 (16.9%), and 38 (45.8%) in acute CSCR and 4 (33.3%), 3 (25%), and 5 (41.7%) in chronic CSCR respectively. There was a significant difference between patients of Persian descent and controls in rs3753394 polymorphism ( P = 0.00, chi-square test). There was no statistical difference in the frequency of polymorphism between acute and chronic patients ( P = 0.64 and P = 0.79 respectively, chi-square test). Conclusions The rs3753394 polymorphism is probably associated with CSCR in Persian ethnicity. Further studies are required to validate the implications of this finding in clinical practice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0950-222X 1476-5454
DOI:	10.1038/s41433-021-01579-x