Search Results - "Touchi, Akira"

Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats by Kanazu, Takushi, Sato, Norihito, Kadono, Kyoko, Touchi, Akira, Takeda, Yuri, Yamaguchi, Yoshitaka, Baba, Takahiko

“…ABSTRACT The in vitro and in vivo inhibition of cytochrome P450 (CYP) 3A with mechanism‐based inhibition (MBI) by macrolides was investigated using…”
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Heterogeneous Liver Lobe Responses of Carbon Tetrachloride-Induced Hepatotoxicity in Male Rats Pretreated with Hepatic Enzyme-Inducing Agents by Uehara, Takeki, Murai, Takashi, Inoue, Satoshi, Maruyama, Toshiyuki, Touchi, Akira, Mori, Satoru, Matsubara, Takashi

“…The present study was designed to compare the susceptibility to carbon tetrachloride (CCl4)-induced hepatotoxicities of the different liver lobes of rats which…”
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Effects of Serum Albumin and Liver Cytosol on CYP2C9- and CYP3A4-mediated Drug Metabolism by Baba, Takahiko, Touchi, Akira, Ito, Kiyomi, Yamaguchi, Yoshitaka, Yamazoe, Yasushi, Ohno, Yasuo, Sugiyama, Yuichi

“…To investigate whether the free-drug theory is accurate in that only unbound drug is available for drug metabolism or enzyme inhibition. The effect of addition…”
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Quantitative determination of cytochrome P-450 in rat liver homogenate by Matsubara, T, Koike, M, Touchi, A, Tochino, Y, Sugeno, K

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Heterogeneous Liver Lobe Responses of Carbon Tetrachloride-Induced Hepatotoxicity in Male Rats Pretreated with Hepatic Enzyme-Inducing Agents by Takeki Uehara, Takashi Murai, Satoshi Inoue, Toshiyuki Maruyama, Akira Touchi, Satoru Mori, Takashi Matsubara

“…The present study was designed to compare the susceptibility to carbon tetrachloride (CC14)-induced hepatotoxicities of the different liver lobes of rats which…”
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HETEROGENEOUS DISTRIBUTION OF THE CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN RAT LIVER LOBES by MATSUBARA, Takashi, TOUCHI, Akira, OGAWA, Ayako

“…Enzyme distribution in rat liver lobes was investigated using liver homogenate as the enzyme source. When the content or the activity was expressed on the…”
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In Vitro Effect of Beta-Lactam Antibiotics and N-Methyl-Tetrazolethiol on Microsomal Vitamin K Epoxide Reductase in Rats by KAWAMOTO, Keiko, TOUCHI, Akira, SUGENO, Koichi, MATSUBARA, Takashi

“…Liver microsomal vitamin K epoxide reductase activity was determined by measuring the formation of menaquinone-4 from the substrate menaquinone-4 2, 3-epoxide…”
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Effect of N-Methyltetrazolethiol on Liver Microsomal gamma-Glutamylcarboxylation: Modification of the In Vitro Action of N-Methyltetrazolethiol by OKA, Tatsushi, TOUCHI, Akira, MATSUBARA, Takashi

“…Vitamin K-dependent gamma-glutamylcarboxylation activity in rat liver microsomes was monitored using the incorporation of 14CO2 into exogenous pentapeptide and…”
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Hepatic Aminopyrine N-Demethylase System: Further Studies of Assay Procedure by Matsubara, Takashi, Touchi, Akira, Tochino, Yosihiro

“…Rat hepatic aminopyrine N-demethylase activity was measured by detecting the amount of formaldehyde produced from aminopyrine. Some optimal conditions for the…”
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Effect of the nonsteroidal anti-inflammatory drug 480156-S on hepatic drug-metabolizing activity and pharmacological action of diazepam and pentobarbital in rats by Matsubara, T, Hirose, K, Hatakeyama, H, Jyoyama, H, Touchi, A, Otsubo, S

“…Effect of the nonsteroidal anti-inflammatory drug 480156-S on liver drug-metabolizing activity was studied in rats, and its effect was compared with that of…”
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In Vitro Effect of Beta-Lactam Antibiotics and N-Methyl-Tetrazolethiol on Microsomal Vitamin K Epoxide Reductase in Rats by KAWAMOTO, Keiko, TOUCHI, Akira, SUGENO, Koichi, MATSUBARA, Takashi

“…Liver microsomal vitamin K epoxide reductase activity was determined by measuring the formation of menaquinone-4 from the substrate menaqunone-4 2,3-epoxide…”
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BIOTRANSFORMATION OF COUMARIN DERIVATIVES (2) OXIDATIVE METABOLISM OF 7-ALKOXYCOUMARIN BY MICROSOMAL ENZYMES AND A SIMPLE ASSAY PROCEDURE FOR 7-ALKOXYCOUMARIN O-DEALKYLASE by MATSUBARA, Takashi, OTSUBO, Shigemi, YOSHIHARA, Emiko, TOUCHI, Akira

“…The in vitro biotransformation of 7-alkoxycoumarin by rat liver microsomes was studied to develop a simple and accurate assay procedure for 7-alkoxycoumarin…”
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In Vitro Effects of Various Heterocyclic Thiol Compounds and β-Lactam Antibiotics on Vitamin K-Dependent γ-Glutamylcarboxylation Activity in Liver Microsomes by OKA, Tatsushi, TOUCHI, Akira, EZUMI, Kiyoshi, YAMAKAWA, Masumi, MATSUBARA, Takashi

“…The in vitro effect of N-methyltetrazolethiol (NMTT), one of the common substituents at the 3'-position of the cephem in various β-lactam antibiotics, on liver…”
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Effect of change of hepatic drug-metabolizing activity on plasma concentrations of major metabolites of the new sleep inducer 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative by MATSUBARA, T, TOUCHI, A, YAMADA, N

“…Plasma concentrations of the major metabolites of 450191-S, a new sleep inducer which is a 1H-1,2,4-triazolyl benzophenone derivative, were determined in rats…”
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Effect of a new sleep inducer, 1H-1,2,4-triazolyl benzophenone derivative 450191-S on rat liver drug-metabolizing enzyme system by Matsubara, T, Touchi, A, Yamada, N, Nishiyama, S

“…The effect of a new sleep inducer, 450191-S, on the hepatic drug-metabolizing enzyme system was examined using rats and compared with those of nitrazepam and…”
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INHIBITORY ACTION OF CEFAMANDOLE ON GLUTAMIC PYRUVIC TRANSAMINASE ACTIVITY IN RATS by MATSUBARA, TAKASHI, TOUCHI, AKIRA

“…Effects of cefamandole sodium and cefazolin sodium administrations on several enzyme activities in plasma and liver were examined in rats. Marked decrease in…”
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Effect of N-Methyltetrazolethiol on Liver Microsomal gamma-Glutamylcarboxylation: Modification of the In Vitro Action of N-Methyltetrazolethiol by OKA, Tatsushi, TOUCHI, Akira, MATSUBARA, Takashi

“…Vitamin K-dependent gamma-glutamylcarboxylation activity in rat liver microsomes was monitored using the incorporation of 14CO2 into exogenous pentapeptide and…”
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HEPATIC AMINOPYRINE N-DEMETHYLASE SYSTEM: EFFECT OF CYANIDE ON MICROSOMAL N-DEMETHYLASE ACTIVITY by MATSUBARA, Takashi, TOUCHI, Akira

“…Cyanide, an inhibitor of many hemoproteins, was shown to affect a number of microsomal drug-metabolizing activities catalyzed by cytochrome P-450. The…”
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Species and Sex Differences in the Inhibitory Action of the Corticosteroid Alclometasone Dipropionate on the Hepatic Drug-Metabolizing System by NISHIBE, Yasuhiro, HAMATAKA, Mitsuko, HASEGAWA, Toshiaki, IKEUCHI, Jiro, YOSHIZAKI, Toshio, TOUCHI, Akira, MATSUBARA, Takashi

“…The effect of successive administration of the corticosteroid alclometasone dipropionate (ACM) on the hepatic drug-metabolizing system was examined using male…”
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Carbon tetrachloride-induced hepatotoxicity in rats: Envidence for different susceptibilities of rat liver lobes by MATSUBARA, Takashi, MORI, Satoru, TOUCHI, Akira, MASUDA, Yoko, TAKEUCHI, Yasuyoshi

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