Search Results - "Toublanc, Nathalie"

Development of an Integrated Population Pharmacokinetic Model for Oral Levetiracetam in Populations of Various Ages and Ethnicities by Toublanc, Nathalie, Lacroix, Brigitte D., Yamamoto, Junichi

“…Levetiracetam [E Keppra®] is a second generation antiepileptic drug for different types of epilepsy in adults and children ≥1 month. The objective is to…”
Get full text

Levetiracetam Intravenous Infusion: A Randomized, Placebo‐controlled Safety and Pharmacokinetic Study by Ramael, Steven, Daoust, Agnès, Otoul, Christian, Toublanc, Nathalie, Troenaru, Mona, Lu, Zhihong (Sarah), Stockis, Armel

“…Purpose: The primary objective of this placebo‐controlled study was to evaluate the safety and tolerability of levetiracetam (LEV) administered intravenously…”
Get full text

Development of an Integrated Population Pharmacokinetic Model for Oral Levetiracetam in Populations of Various Ages and Ethnicities by Nathalie TOUBLANC, Brigitte D.LACROIX, Junichi YAMAMOTO

“…[Summary] Levetiracetam [E Keppra(R)(R)] is a second generation antiepileptic drug for different types of epilepsy in adults and children >1 month. The…”
Get full text

Minimal to no transfer of certolizumab pegol into breast milk: results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study by Clowse, Megan Eb, Förger, Frauke, Hwang, Caroline, Thorp, John, Dolhain, Radboud Jem, van Tubergen, Astrid, Shaughnessy, Laura, Simpson, Jeff, Teil, Marie, Toublanc, Nathalie, Wang, Maggie, Hale, Thomas W

“…Women with chronic inflammatory diseases face uncertainty regarding the safety of biologics during breast feeding. CRADLE was the first industry-sponsored…”
Get more information

Levetiracetam Pharmacokinetics in Japanese Subjects with Renal Impairment by Yamamoto, Junichi, Toublanc, Nathalie, Kumagai, Yuji, Stockis, Armel

“…Background and Objective The anti-epileptic drug levetiracetam is excreted renally. The objective of this trial was to evaluate the pharmacokinetics of…”
Get full text

Retrospective Population Pharmacokinetic Analysis of Levetiracetam in Children and Adolescents with Epilepsy: Dosing Recommendations by Toublanc, Nathalie, Sargentini-Maier, Maria Laura, Lacroix, Brigitte, Jacqmin, Philippe, Stockis, Armel

“…Objective: To characterize levetiracetam pharmacokinetics, identify significant covariate relationships and identify doses in children that achieve blood…”
Get full text

Pharmacokinetics, Safety and Bioequivalence of Levetiracetam Intravenous Infusion and Oral Tablets in Healthy Chinese Subjects by Toublanc, Nathalie, Du, Xinlu, Liu, Yun, Chen, Qian, Singh, Pritibha, Chan, Robert, Stockis, Armel

“…Background and Objective Levetiracetam is available in China as adjunctive oral therapy for partial-onset seizures. This study was conducted to evaluate the…”
Get full text

692: Evaluating transfer of certolizumab pegol into breast milk: results from a prospective, postmarketing, multicenter pharmacokinetic study by Thorp, John, Clowse, Megan E.B, Förger, Frauke, Hwang, Caroline, Dolhain, Radboud J.E.M, van Tubergen, Astrid, Shaughnessy, Laura, Simpson, Jeff, Teil, Marie, Toublanc, Nathalie, Wang, Maggie, Hale, Thomas W

Get full text

Evaluating Transfer of Certolizumab Pegol into Breast Milk: Results from CRADLE, a Prospective, Postmarketing, Multicenter Pharmacokinetics Study: 573 by Hwang, Caroline, Clowse, Megan E. B., Förger, Frauke, Thorp, John, Dolhain, Radboud J. E. M., van Tubergen, Astrid, Shaughnessy, Laura, Simpson, Jeff, Teil, Marie, Toublanc, Nathalie, Wang, Maggie, Hale, Thomas W.

Get full text

Prospective Open-Label, Single-Arm, Multicenter, Safety, Tolerability, and Pharmacokinetic Studies of Intravenous Levetiracetam in Children With Epilepsy by Weinstock, Arie, Ruiz, Matilde, Gerard, Danielle, Toublanc, Nathalie, Stockis, Armel, Farooq, Osman, Dilley, Deanne, Karmon, Yuval, Elgie, Mary Jo, Schiemann-Delgado, Jimmy

“…Levetiracetam given via intravenous administration has been shown to be an effective alternative in adults with epilepsy when oral administration is not…”
Get full text

Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects by Ramael, Steven, De Smedt, Florence, Toublanc, Nathalie, Otoul, Christian, Boulanger, Pierre, Riethuisen, Jean-Michel, Stockis, Armel

“…Background: Antiepileptic drugs are usually administere dorally, but alternative routes of drug delivery may be required when oral administration is not…”
Get full text

Seletracetam (UCB 44212) by Bennett, Barbara, Matagne, Alain, Michel, Philippe, Leonard, Michèle, Cornet, Miranda, Meeus, Marie-Anne, Toublanc, Nathalie

“…Better pharmacotherapies for epilepsy are needed for patients who are refractory to or have tolerability difficulties with current treatments. Seletracetam, a…”
Get full text

Pharmacokinetics of the antiepileptic drug levetiracetam in healthy Japanese and Caucasian volunteers following intravenous administration by Toublanc, Nathalie, Okagaki, Takuya, Boyce, Malcolm, Chan, Robert, Mugitani, Ayumi, Watanabe, Shikiko, Yamamoto, Katsumi, Yoshida, Katsumi, Andreas, Jens-Otto

“…The intravenous (iv) formulation of levetiracetam has been available in clinical practice worldwide for several years, but not in Japan. Two open-label studies…”
Get full text

Population pharmacokinetic-pharmacodynamic modeling of moxonidine using 24-hour ambulatory blood pressure measurements by Hempel, Georg, Karlsson, Mats O., Alwis, Dinesh P., Toublanc, Nathalie, McNay, John, Schaefer, Hans G.

“…Objectives To develop a model for 24‐hour ambulatory blood pressure measurements (ABPM) that can be applied in a pharmacokinetic‐pharmacodynamic model. Methods…”
Get full text

Talampanel, a New Antiepileptic Drug: Single and Multiple‐dose Pharmacokinetics and Initial One Week Experience in Patients with Chronic Intractable Epilepsy by Langan, Yvonne M., Lucas, Richard, Jewell, Haley, Toublanc, Nathalie, Schaefer, Hans, Sander, Josemir W.A.S., Patsalos, Philip N.

Get full text