Proton magnetic resonance spectroscopic analysis of changes in brain metabolites following electroconvulsive therapy in patients with major depressive disorder

Proton magnetic resonance spectroscopic analysis of changes in brain metabolites following electroconvulsive therapy in patients with major depressive disorder

Objectives: The aim of this study was to evaluate the metabolic changes in the anterior cingulate cortex (ACC) induced by electroconvulsive therapy (ECT) in patients with MDD via 1 H-MRS. Methods: The study was conducted on 13 MDD patients receiving ECT treatment and 14 healthy controls matched in t...

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Published in:International journal of psychiatry in clinical practice Vol. 24; no. 1; pp. 96 - 101
Main Authors: Tosun, Şakir, Tosun, Mesude, Akansel, Gür, Gökbakan, Aziz Mehmet, Ünver, Hatice, Tural, Ümit
Format: Journal Article
Language:English
Published: England Taylor & Francis 02-01-2020
Subjects:
ACC
Adult
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
choline
Choline - metabolism
Creatine - metabolism
creatinine
Depressive Disorder, Major - diagnostic imaging
Depressive Disorder, Major - metabolism
Depressive Disorder, Major - therapy
ECT
Electroconvulsive Therapy
Female
Gyrus Cinguli - diagnostic imaging
Gyrus Cinguli - metabolism
H-MRS
Humans
Male
MDD
Middle Aged
NAA
Proton Magnetic Resonance Spectroscopy
Treatment Outcome
ACC
choline
creatinine
H-MRS
ECT
MDD
NAA
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Summary:Objectives: The aim of this study was to evaluate the metabolic changes in the anterior cingulate cortex (ACC) induced by electroconvulsive therapy (ECT) in patients with MDD via 1 H-MRS. Methods: The study was conducted on 13 MDD patients receiving ECT treatment and 14 healthy controls matched in terms of age, gender and education. The patients underwent six sessions of ECT. 1 H-MRS imaging and psychometric evaluations obtained before 1st and after the 6th sessions. The control group also went through the same procedures except for ECT. N-Acetyl aspartate (NAA), choline (Cho) and creatine (Cr) metabolite levels and the creatine to metabolite ratios were measured. Results: There was no significant difference in the ACC metabolite levels of the patients and those of the controls at the baseline. ECT associated with a statistically significant decrease in the NAA/Cr ratio in ACC. All of the patients had responded to ECT treatment as measured with the clinical scales. Conclusions: The results has suggested that indirect proof of an increase in energy metabolism without any evidence of impaired neuronal viability in the ACC induced by ECT. The relative increase in Cr levels following ECT in MDD seems to be associated with improvement in clinical severity. Key points ECT is one the most effective method in the treatment of acute MDD. The mechanism of ECT's antidepressant activity remains unclear but it is thought to be related to the regulation of prefrontal cortical or cingulate areas. In this study the patients underwent six sessions of ECT and after 1 H-MRS imaging. The study revealed that baseline levels of metabolites in patients with MDD were not significantly different than those of control group.
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content type line 23
ISSN:1365-1501
1471-1788
DOI:10.1080/13651501.2019.1699118