Search Results - "Tosi, Tommaso"

Binding of Cyclic Di-AMP to the Staphylococcus aureus Sensor Kinase KdpD Occurs via the Universal Stress Protein Domain and Downregulates the Expression of the Kdp Potassium Transporter by Moscoso, Joana A, Schramke, Hannah, Zhang, Yong, Tosi, Tommaso, Dehbi, Amina, Jung, Kirsten, Gründling, Angelika

“…Nucleotide signaling molecules are important intracellular messengers that regulate a wide range of biological functions. The human pathogen Staphylococcus…”
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Balancing the Scale: Data Augmentation Techniques for Improved Supervised Learning in Cyberattack Detection by Medvedieva, Kateryna, Tosi, Tommaso, Barbierato, Enrico, Gatti, Alice

“…The increasing sophistication of cyberattacks necessitates the development of advanced detection systems capable of accurately identifying and mitigating…”
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Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM by Tosi, Tommaso, Hoshiga, Fumiya, Millership, Charlotte, Singh, Rahul, Eldrid, Charles, Patin, Delphine, Mengin-Lecreulx, Dominique, Thalassinos, Konstantinos, Freemont, Paul, Gründling, Angelika

“…c-di-AMP is an important second messenger molecule that plays a pivotal role in regulating fundamental cellular processes, including osmotic and cell wall…”
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Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin by Kaplan-Türköz, Burcu, Jiménez-Soto, Luisa F, Dian, Cyril, Ertl, Claudia, Remaut, Han, Louche, Arthur, Tosi, Tommaso, Haas, Rainer, Terradot, Laurent

“…Infection with the gastric pathogen Helicobacter pylori is a risk factor for the development of gastric cancer. Pathogenic strains of H. pylori carry a type IV…”
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Expression of Helicobacter pylori CagA domains by library-based construct screening by Angelini, Alessandro, Tosi, Tommaso, Mas, Philippe, Acajjaoui, Samira, Zanotti, Giuseppe, Terradot, Laurent, Hart, Darren J

“…Highly pathogenic strains of Helicobacter pylori use a type IV secretion system to inject the CagA protein into human gastric cells. There, CagA associates…”
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The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus by Schuster, Christopher F, Bellows, Lauren E, Tosi, Tommaso, Campeotto, Ivan, Corrigan, Rebecca M, Freemont, Paul, Gründling, Angelika

“…Staphylococcus aureus is an important opportunistic human pathogen that is highly resistant to osmotic stresses. To survive an increase in osmolarity, bacteria…”
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Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors by Chee Wezen, Xavier, Chandran, Aneesh, Eapen, Rohan Sakariah, Waters, Elaine, Bricio-Moreno, Laura, Tosi, Tommaso, Dolan, Stephen, Millership, Charlotte, Kadioglu, Aras, Gründling, Angelika, Itzhaki, Laura S., Welch, Martin, Rahman, Taufiq

“…Lipoteichoic acid synthase (LtaS) is a key enzyme for the cell wall biosynthesis of Gram-positive bacteria. Gram-positive bacteria that lack lipoteichoic acid…”
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Structural basis for the inhibition of the Bacillus subtilis c-di-AMP cyclase CdaA by the phosphoglucomutase GlmM by Pathania, Monisha, Tosi, Tommaso, Millership, Charlotte, Hoshiga, Fumiya, Morgan, Rhodri M.L., Freemont, Paul S., Gründling, Angelika

“…Cyclic-di-adenosine monophosphate (c-di-AMP) is an important nucleotide signaling molecule that plays a key role in osmotic regulation in bacteria. c-di-AMP is…”
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Structural Similarity of Secretins from Type II and Type III Secretion Systems by Tosi, Tommaso, Estrozi, Leandro F., Job, Viviana, Guilvout, Ingrid, Pugsley, Anthony P., Schoehn, Guy, Dessen, Andréa

“…Secretins, the outer membrane components of several secretion systems in Gram-negative bacteria, assemble into channels that allow exoproteins to traverse the…”
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Structural basis of eukaryotic cell targeting by type III secretion system (T3SS) effectors by Tosi, Tommaso, Pflug, Alexander, Discola, Karen F., Neves, David, Dessen, Andréa

“…Type III secretion systems (T3SS) are macromolecular complexes that translocate a wide number of effector proteins into eukaryotic host cells. Once within the…”
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Outer Membrane Targeting of Secretin PulD Protein Relies on Disordered Domain Recognition by a Dedicated Chaperone by Nickerson, Nicholas N., Tosi, Tommaso, Dessen, Andréa, Baron, Bruno, Raynal, Bertrand, England, Patrick, Pugsley, Anthony P.

“…Interaction of bacterial outer membrane secretin PulD with its dedicated lipoprotein chaperone PulS relies on a disorder-to-order transition of the chaperone…”
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High-yield ‘one-pot’ biosynthesis of raspberry ketone, a high-value fine chemical by Moore, Simon J, Tosi, Tommaso, Bell, David, Hleba, Yonek B, Polizzi, Karen M, Freemont, Paul S

“…Abstract Cell-free extract and purified enzyme-based systems provide an attractive solution to study biosynthetic strategies towards a range of chemicals…”
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Pilotin–secretin recognition in the type II secretion system of Klebsiella oxytoca by Tosi, Tommaso, Nickerson, Nicholas N., Mollica, Luca, Jensen, Malene Ringkjøbing, Blackledge, Martin, Baron, Bruno, England, Patrick, Pugsley, Anthony P., Dessen, Andréa

“…Summary A crucial aspect of the functionality of bacterial type II secretion systems is the targeting and assembly of the outer membrane secretin. In the…”
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Structures of the tumor necrosis factor α inducing protein Tipα: A novel virulence factor from Helicobacter pylori by Tosi, Tommaso, Cioci, Gianluca, Jouravleva, Karina, Dian, Cyril, Terradot, Laurent

“…Helicobacter pylori secretes a unique virulence factor, Tipα, that enters gastric cells and both stimulates the production of the TNF-α and activates the NF-κB…”
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Structural insights into Helicobacter pylori oncoprotein CagA interaction with [Beta]1 integrin by Kaplan-Türköz, Burcu, Jiménez-Soto, Luisa F, Dian, Cyril, Ertl, Claudia, Remaut, Han, Louche, Arthur, Tosi, Tommaso, Haas, Rainer, Terradot, Laurent

“…Infection with the gastric pathogen Helicobacter pylori is a risk factor for the development of gastric cancer. Pathogenic strains of H. pylori carry a type IV…”
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Expression of Helicobacterpylori CagA domains by library-based construct screening by Angelini, Alessandro, Tosi, Tommaso, Mas, Philippe, Acajjaoui, Samira, Zanotti, Giuseppe, Terradot, Laurent, Hart, Darren J

“…Highly pathogenic strains of Helicobacterpylori use a typeIV secretion system to inject the CagA protein into human gastric cells. There, CagA associates with…”
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Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori by Tosi, Tommaso, Cioci, Gianluca, Jouravleva, Karina, Dian, Cyril, Terradot, Laurent

“…Helicobacter pylori secretes a unique virulence factor, Tipalpha, that enters gastric cells and both stimulates the production of the TNF-alpha and activates…”
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Structural biology of Helicobacter pylori type IV secretion system by Angelini, Alessandro, Cendron, Laura, Seydel, Anke, Barison, Nicola, Tosi, Tommaso, Battistutta, Roberto, Zanotti, Giuseppe

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