Search Results - "Toshkov, Ilia A"

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates by Krivokrysenko, Vadim I, Toshkov, Ilia A, Gleiberman, Anatoli S, Krasnov, Peter, Shyshynova, Inna, Bespalov, Ivan, Maitra, Ratan K, Narizhneva, Natalya V, Singh, Vijay K, Whitnall, Mark H, Purmal, Andrei A, Shakhov, Alexander N, Gudkov, Andrei V, Feinstein, Elena

“…There are currently no approved medical radiation countermeasures (MRC) to reduce the lethality of high-dose total body ionizing irradiation expected in…”
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A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications by Mett, Vadim, Kurnasov, Oleg V., Bespalov, Ivan A., Molodtsov, Ivan, Brackett, Craig M., Burdelya, Lyudmila G., Purmal, Andrei A., Gleiberman, Anatoli S., Toshkov, Ilia A., Burkhart, Catherine A., Kogan, Yakov N., Andrianova, Ekaterina L., Gudkov, Andrei V., Osterman, Andrei L.

“…The Toll-like receptor 5 (TLR5) agonist entolimod, a derivative of Salmonella flagellin, has therapeutic potential for several indications including…”
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Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice by Kojouharov, Bojidar M, Brackett, Craig M, Veith, Jean M, Johnson, Christopher P, Gitlin, Ilya I, Toshkov, Ilia A, Gleiberman, Anatoli S, Gudkov, Andrei V, Burdelya, Lyudmila G

“…Myelosuppression and gastrointestinal damage are common side effects of cancer treatment limiting efficacy of DNA-damaging chemotherapeutic drugs. The…”
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Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation by Toshkov, Ilia A., Gleiberman, Anatoli S., Mett, Vadim L., Hutson, Alan D., Singh, Anurag K., Gudkov, Andrei V., Burdelya, Lyudmila G.

“…Radiation treatment of head and neck cancer frequently causes severe collateral damage to normal tissues including mouth mucosa, salivary glands and skin. This…”
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Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection by Tennant, Bud C., Toshkov, Ilia A., Peek, Simon F., Jacob, James R., Menne, Stephan, Hornbuckle, William E., Schinazi, Raymond D., Korba, Brent E., Cote, Paul J., Gerin, John L.

“…The Eastern woodchuck ( Marmota monax) harbors a DNA virus (Woodchuck hepatitis virus [WHV]) that is similar in structure and replicative life cycle to the…”
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Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection by Menne, Stephan, Cote, Paul J., Butler, Scott D., Toshkov, Ilia A., Gerin, John L., Tennant, Bud C.

“…Resolution of hepatitis B virus (HBV) infection is characterized by coordinated humoral and cellular immune responses. Immunity is durable over decades,…”
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Antiviral activity of clevudine [ L-FMAU, (1-(2-fluoro-5-methyl-β, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks ( Marmota monax) by Peek, Simon F., Cote, Paul J., Jacob, James R., Toshkov, Ilia A., Hornbuckle, William E., Baldwin, Betty H., Wells, Frances V., Chu, C.K., Gerin, John L., Tennant, Bud C., Korba, Brent E.

“…L-FMAU [1-(2-fluoro-5-methyl-β, L-arabinofuranosyl) uracil] has been shown to be an effective inhibitor of hepatitis B virus (HBV) and duck hepatitis B virus…”
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Integration of woodchuck hepatitis and N‐myc rearrangement determine size and histologic grade of hepatic tumors by Jacob, James R., Sterczer, Agnes, Toshkov, Ilia A., Yeager, Amy E., Korba, Brent E., Cote, Paul J., Buendia, Marie‐Annick, Gerin, John L., Tennant, Bud C.

“…Integrations of woodchuck hepatitis virus (WHV) DNA and rearrangements of the N‐myc 2 gene have been detected frequently in hepatocellular carcinoma (HCC) of…”
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Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency by Cheng, L, Zhou, Z, Flesken-Nikitin, A, Toshkov, I A, Wang, W, Camps, J, Ried, T, Nikitin, A Y

“…Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We…”
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Abstract 2467: Role of adrenomedullin in woodchuck hepatocarcinogenesis by Ochoa, Laura, Coca, Valle, Toshkov, Ilia A., Liu, Katherine H., Menne, Stephan, Martínez, Alfredo

“…Abstract The aim of this study is to investigate the role of adrenomedullin (AM) during the development of hepatocellular carcinoma (HCC). AM is a growth…”
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The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates: e0135388 by Krivokrysenko, Vadim I, Toshkov, Ilia A, Gleiberman, Anatoli S, Krasnov, Peter, Shyshynova, Inna, Bespalov, Ivan, Maitra, Ratan K, Narizhneva, Natalya V, Singh, Vijay K, Whitnall, Mark H

“…There are currently no approved medical radiation countermeasures (MRC) to reduce the lethality of high-dose total body ionizing irradiation expected in…”
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Dietary energy restriction-induced modulation of protein kinase C zeta isozyme in the hamster pancreas by Nair, S C, Toshkov, I A, Yaktine, A L, Barnett, T D, Chaney, W G, Birt, D F

“…Dietary restriction in experimental animals enhances life span, delays disease, inhibits immunological perturbations, and ameliorates cancer. Protein kinase C…”
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Virus-induced pancreatic cancer in guinea fowl: a morphologic study by Kirev, T T, Toshkov, I A, Mladenov, Z M

“…The morphologic lesions in the pancreas of 350 guinea fowls infected with avian osteopetrosis virus strain Pts-56 were studied. Focal unspecific changes in the…”
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Virus-induced duodenal adenomas in guinea fowl by Kirev, T T, Toshkov, I A, Mladenov, Z M

“…Polypous growths of the duodenal mucosa were induced in guinea fowls after iv inoculation o virus strain Pts-56. The growths developed in about 60% of the…”
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A novel adhesion factor produced by hamster pancreatic cancer cell line is effective on normal and carcinoma cell lines of different species by Toshkov, I A, Chaney, W G, Colcher, D M, Hollingsworth, M A, Bratanova, T K, Perini, F, Pour, P M

“…An adhesion factor, produced by the hamster pancreatic cancer cell line PC-1.0, was tested for its efficiency in promoting the in vitro adhesion of normal and…”
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Pathogenic effect of osteopetrosis virus strain MAV-2(0) on guinea fowl pancreas by Kirev, T T, Toshkov, I A, Mladenov, Z M

“…Osteopetrosis virus strain MAV-2(0) in guinea fowl pancreas induces early unspecific changes in separate acini and the development of neoplasia among…”
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