Search Results - "Toshkov, A"

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates by Krivokrysenko, Vadim I, Toshkov, Ilia A, Gleiberman, Anatoli S, Krasnov, Peter, Shyshynova, Inna, Bespalov, Ivan, Maitra, Ratan K, Narizhneva, Natalya V, Singh, Vijay K, Whitnall, Mark H, Purmal, Andrei A, Shakhov, Alexander N, Gudkov, Andrei V, Feinstein, Elena

“…There are currently no approved medical radiation countermeasures (MRC) to reduce the lethality of high-dose total body ionizing irradiation expected in…”
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Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR by Schug, Thaddeus T, Berry, Daniel C, Toshkov, Illia A, Cheng, Le, Nikitin, Alexander Yu, Noy, Noa

“…Retinoic acid (RA) displays potent anticarcinogenic activities that are mediated by the nuclear retinoic acid receptors (RARs). However, use of RA in oncology…”
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Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice by Clark, P.J, Brzezinska, W.J, Thomas, M.W, Ryzhenko, N.A, Toshkov, S.A, Rhodes, J.S

“…Abstract The mammalian hippocampus continues to generate new neurons throughout life. Experiences such as exercise, anti-depressants, and stress regulate…”
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A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications by Mett, Vadim, Kurnasov, Oleg V., Bespalov, Ivan A., Molodtsov, Ivan, Brackett, Craig M., Burdelya, Lyudmila G., Purmal, Andrei A., Gleiberman, Anatoli S., Toshkov, Ilia A., Burkhart, Catherine A., Kogan, Yakov N., Andrianova, Ekaterina L., Gudkov, Andrei V., Osterman, Andrei L.

“…The Toll-like receptor 5 (TLR5) agonist entolimod, a derivative of Salmonella flagellin, has therapeutic potential for several indications including…”
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Correction to: Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency by Cheng, L., Zhou, Z., Flesken-Nikitin, A., Toshkov, I. A., Wang, W., Camps, J., Ried, T., Nikitin, A. Y.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41388-021-01647-2…”
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Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis by Antoch, Marina P., Gorbacheva, Victoria Y., Vykhovanets, Olena, Toshkov, Illia A., Kondratov, Roman V., Kondratova, Anna A., Lee, Choogon, Nikitin, Alexander Yu

“…The mammalian circadian system has been implicated in the regulation of various biological processes including those involved in genotoxic stress responses and…”
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Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency by Cheng, L, Zhou, Z, Flesken-Nikitin, A, Toshkov, I A, Wang, W, Camps, J, Ried, T, Nikitin, A Y

“…Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We…”
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Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice by Kojouharov, Bojidar M, Brackett, Craig M, Veith, Jean M, Johnson, Christopher P, Gitlin, Ilya I, Toshkov, Ilia A, Gleiberman, Anatoli S, Gudkov, Andrei V, Burdelya, Lyudmila G

“…Myelosuppression and gastrointestinal damage are common side effects of cancer treatment limiting efficacy of DNA-damaging chemotherapeutic drugs. The…”
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A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice by Leonova, Katerina I., Shneyder, Jelena, Antoch, Marina P., Toshkov, Illia A., Novototskaya, Liliya R., Komarov, Pavel G., Komarova, Elena A., Gudkov, Andrei V.

“…It has been shown that genetic inhibition of p53 leads to enhanced proliferation of hematopoietic stem cells (HSCs). This could, in theory, contribute to the…”
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Antiviral activity of clevudine [ L-FMAU, (1-(2-fluoro-5-methyl-β, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks ( Marmota monax) by Peek, Simon F., Cote, Paul J., Jacob, James R., Toshkov, Ilia A., Hornbuckle, William E., Baldwin, Betty H., Wells, Frances V., Chu, C.K., Gerin, John L., Tennant, Bud C., Korba, Brent E.

“…L-FMAU [1-(2-fluoro-5-methyl-β, L-arabinofuranosyl) uracil] has been shown to be an effective inhibitor of hepatitis B virus (HBV) and duck hepatitis B virus…”
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Clevudine Inhibits Hepatitis Delta Virus Viremia: a Pilot Study of Chronically Infected Woodchucks by CASEY, John, COTE, Paul J, TOSHKOV, Illia A, CHU, Chung K, GERIN, John L, HORNBUCKLE, William E, TENNANT, Bud C, KORBA, Brent E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy by Mett, V, Komarova, E A, Greene, K, Bespalov, I, Brackett, C, Gillard, B, Gleiberman, A S, Toshkov, I A, Aygün-Sunar, S, Johnson, C, Karasik, E, Bapardekar-Nair, M, Kurnasov, O V, Osterman, A L, Stanhope-Baker, P S, Morrison, C, Moser, M T, Foster, B A, Gudkov, A V

“…Toll-like receptor 5 (TLR5) is considered an attractive target for anticancer immunotherapy. TLR5 agonists, bacterial flagellin and engineered flagellin…”
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Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation by Toshkov, Ilia A., Gleiberman, Anatoli S., Mett, Vadim L., Hutson, Alan D., Singh, Anurag K., Gudkov, Andrei V., Burdelya, Lyudmila G.

“…Radiation treatment of head and neck cancer frequently causes severe collateral damage to normal tissues including mouth mucosa, salivary glands and skin. This…”
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Integration of woodchuck hepatitis and N‐myc rearrangement determine size and histologic grade of hepatic tumors by Jacob, James R., Sterczer, Agnes, Toshkov, Ilia A., Yeager, Amy E., Korba, Brent E., Cote, Paul J., Buendia, Marie‐Annick, Gerin, John L., Tennant, Bud C.

“…Integrations of woodchuck hepatitis virus (WHV) DNA and rearrangements of the N‐myc 2 gene have been detected frequently in hepatocellular carcinoma (HCC) of…”
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Effect of Sequential Treatment of Warm Water Dip and Low-dose Gamma Irradiation on the Quality of Fresh-cut Green Onions by Kim, Hyun Jung, Feng, Hao, Toshkov, Stoyan A., Fan, Xuetong

“…The effect of warm water dip in combination with irradiation on quality of fresh‐cut green onions was studied. Fresh‐cut green onions were treated with and…”
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Hepatic expression of the woodchuck hepatitis virus X‐antigen during acute and chronic infection and detection of a woodchuck hepatitis virus X‐antigen antibody response by Jacob, J R, Ascenzi, M A, Roneker, C A, Toshkov, I A, Cote, P J, Gerin, J L, Tennant, B C

“…The expression and localization of the woodchuck hepatitis virus X‐antigen (WHxAg) was examined and compared with other markers of a woodchuck hepatitis virus…”
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Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection by Tennant, Bud C., Toshkov, Ilia A., Peek, Simon F., Jacob, James R., Menne, Stephan, Hornbuckle, William E., Schinazi, Raymond D., Korba, Brent E., Cote, Paul J., Gerin, John L.

“…The Eastern woodchuck ( Marmota monax) harbors a DNA virus (Woodchuck hepatitis virus [WHV]) that is similar in structure and replicative life cycle to the…”
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Development of an optimised papaya pulp nectar using a combination of irradiation and mild heat by Parker, Tory L., Esgro, Sarah T., Miller, Samantha A., Myers, Lauren E., Meister, Rustin A., Toshkov, Stoyan A., Engeseth, Nicki J.

“…Papaya does not sufficiently maintain desired fresh fruit quality when shipped long distances due to an easily bruised soft skin and a short shelf life. This…”
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Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection by Menne, Stephan, Cote, Paul J., Butler, Scott D., Toshkov, Ilia A., Gerin, John L., Tennant, Bud C.

“…Resolution of hepatitis B virus (HBV) infection is characterized by coordinated humoral and cellular immune responses. Immunity is durable over decades,…”
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Dietary energy restriction-induced modulation of protein kinase C zeta isozyme in the hamster pancreas by Nair, S C, Toshkov, I A, Yaktine, A L, Barnett, T D, Chaney, W G, Birt, D F

“…Dietary restriction in experimental animals enhances life span, delays disease, inhibits immunological perturbations, and ameliorates cancer. Protein kinase C…”
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