Search Results - "Toshihiro Tsukui"

A pilot clinical study of the therapeutic antibody against canine PD-1 for advanced spontaneous cancers in dogs by Igase, Masaya, Nemoto, Yuki, Itamoto, Kazuhito, Tani, Kenji, Nakaichi, Munekazu, Sakurai, Masashi, Sakai, Yusuke, Noguchi, Shunsuke, Kato, Masahiro, Tsukui, Toshihiro, Mizuno, Takuya

“…Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as…”
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Generation of a canine anti-canine CD20 antibody for canine lymphoma treatment by Mizuno, Takuya, Kato, Yukinari, Kaneko, Mika K., Sakai, Yusuke, Shiga, Toshinori, Kato, Masahiro, Tsukui, Toshihiro, Takemoto, Hirofumi, Tokimasa, Akio, Baba, Kenji, Nemoto, Yuki, Sakai, Osamu, Igase, Masaya

“…Lymphoma is the most common hematological cancer in dogs. Canine diffuse large B cell lymphoma shows a relatively good response to treatment with multi-agent…”
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Examination of yield, bacteriolytic activity and cold storage of linker deletion mutants based on endolysin S6_ORF93 derived from Staphylococcus giant bacteriophage S6 by Munetomo, Sosuke, Uchiyama, Jumpei, Takemura-Uchiyama, Iyo, Wanganuttara, Thamonwan, Yamamoto, Yumiko, Tsukui, Toshihiro, Hagiya, Hideharu, Kanamaru, Shuji, Kanda, Hideyuki, Matsushita, Osamu

“…Methicillin-resistant Staphylococcus spp. present challenges in clinical and veterinary settings because effective antimicrobial agents are limited…”
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Development of a monoclonal antibody for the detection of anti-canine CD20 chimeric antigen receptor expression on canine CD20 chimeric antigen receptor-transduced T cells by SAKAI, Osamu, OGINO, Shoji, TSUKUI, Toshihiro, IGASE, Masaya, MIZUNO, Takuya

“…Chimeric antigen receptor (CAR) CAR-T cell therapy targeting CD20 can be a novel adoptive cell therapy for canine patients with B-cell malignancy. After…”
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Therapeutic Potential of an Endolysin Derived from Kayvirus S25-3 for Staphylococcal Impetigo by Imanishi, Ichiro, Uchiyama, Jumpei, Tsukui, Toshihiro, Hisatsune, Junzo, Ide, Kaori, Matsuzaki, Shigenobu, Sugai, Motoyuki, Nishifuji, Koji

“…Impetigo is a contagious skin infection predominantly caused by . Decontamination of from the skin is becoming more difficult because of the emergence of…”
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Proof-of-concept study of the caninized anti-canine programmed death 1 antibody in dogs with advanced non-oral malignant melanoma solid tumors by Igase, Masaya, Inanaga, Sakuya, Nishibori, Shoma, Itamoto, Kazuhito, Sunahara, Hiroshi, Nemoto, Yuki, Tani, Kenji, Horikirizono, Hiro, Nakaichi, Munekazu, Baba, Kenji, Kambayashi, Satoshi, Okuda, Masaru, Sakai, Yusuke, Sakurai, Masashi, Kato, Masahiro, Tsukui, Toshihiro, Mizuno, Takuya

“…The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed the caninized…”
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Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non-cell-autonomous pathogenesis of degenerative myelopathy by Kobatake, Yui, Sakai, Hiroki, Tsukui, Toshihiro, Yamato, Osamu, Kohyama, Moeko, Sasaki, Jun, Kato, Shinsuke, Urushitani, Makoto, Maeda, Sadatoshi, Kamishina, Hiroaki

“…Abstract Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder. Dogs with typical clinical signs carry homozygous mutations in the…”
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Establishment of rat anti-canine DEP domain containing 1B (DEPDC1B) monoclonal antibodies by IGASE, Masaya, MORINAGA, Yuki, KATO, Masahiro, TSUKUI, Toshihiro, SAKAI, Yusuke, OKUDA, Masaru, MIZUNO, Takuya

“…DEP domain-containing 1B (DEPDC1B) is involved in the regulation of cell de-adhesion and actin cytoskeleton activity during the G2/M transition of the cell…”
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Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9 by Coban, Cevayir, Igari, Yoshikatsu, Yagi, Masanori, Reimer, Thornik, Koyama, Shohei, Aoshi, Taiki, Ohata, Keiichi, Tsukui, Toshihiro, Takeshita, Fumihiko, Sakurai, Kazuo, Ikegami, Takahisa, Nakagawa, Atsushi, Horii, Toshihiro, Nuñez, Gabriel, Ishii, Ken J, Akira, Shizuo

“…Although whole-parasite vaccine strategies for malaria infection have regained attention, their immunological mechanisms of action remain unclear. We find that…”
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Current status of synthetic hemozoin adjuvant: A preliminary safety evaluation by Lee, Michelle Sue Jann, Igari, Yoshikatsu, Tsukui, Toshihiro, Ishii, Ken J, Coban, Cevayir

“…Highlights • Hemozoin is a by-product of Plasmodium parasites. • Synthetic hemozoin (sHZ) is a potent adjuvant in vaccine formulations. • Optimized sHZ…”
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Antimicrobial resistance and genotyping of Pseudomonas aeruginosa isolated from the ear canals of dogs in Japan by Elfadadny, Ahmed, Uchiyama, Jumpei, Goto, Kazuyoshi, Imanishi, Ichiro, Ragab, Rokaia F, Nageeb, Wedad M, Iyori, Keita, Toyoda, Yoichi, Tsukui, Toshihiro, Ide, Kaori, Kawamoto, Keiko, Nishifuji, Koji

“…The strong bond between dogs and their owners creates a close association that could result in the transfer of antibiotic-resistant bacteria from canines to…”
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The Malarial Metabolite Hemozoin and Its Potential Use as a Vaccine Adjuvant by Coban, Cevayir, Yagi, Masanori, Ohata, Keiichi, Igari, Yoshikatsu, Tsukui, Toshihiro, Horii, Toshihiro, Ishii, Ken J, Akira, Shizuo

“…Hemozoin, a bio-crystalline substance, is a hemin detoxification by-product of malaria parasites. The role of hemozoin crystals in host immune system…”
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Proof-of-concept study of the caninized anti-canine programmed death 1 antibody in dogs with advanced non-oral malignant melanoma solid tumors by Masaya Igase, Sakuya Inanaga, Shoma Nishibori, Kazuhito Itamoto, Hiroshi Sunahara, Yuki Nemoto, Kenji Tani, Hiro Horikirizono, Munekazu Nakaichi, Kenji Baba, Satoshi Kambayashi, Masaru Okuda, Yusuke Sakai, Masashi Sakurai, Masahiro Kato, Toshihiro Tsukui, Takuya Mizuno

“…Background: The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed…”
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Establishment of a quantitative ELISA for the measurement of allergen-specific IgE in dogs using anti-IgE antibody cross-reactive to mouse and dog IgE by Okayama, Taro, Matsuno, Yukiko, Yasuda, Nobutaka, Tsukui, Toshihiro, Suzuta, Yasuyuki, Koyanagi, Masanori, Sakaguchi, Masahiro, Ishii, Yasuyuki, Olivry, Thierry, Masuda, Kenichi

“…As IgE plays a pivotal role in type I hypersensitivity-mediated allergic diseases, it is valuable to measure absolute quantity of serum antigen-specific IgE…”
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Measurement for Canine IgE Using Canine Recombinant High Affinity IgE Receptor α Chain (FcεRIα) by TSUKUI, Toshihiro, SAKAGUCHI, Masahiro, KURATA, Keigo, MAEDA, Sadatoshi, OHMORI, Keitaro, MASUDA, Kenichi, TSUJIMOTO, Hajime, IWABUCHI, Shigehiro

“…To detect allergen-specific IgE in dogs with allergic diseases, we developed a recombinant canine high affinity IgE receptor α chain (FcεRIα)-based IgE…”
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Development of an in vitro assay for screening programmed death receptor-1/programmed cell death ligand 1 monoclonal antibody therapy in dogs by Mizuno, Takuya, Kato, Masahiro, Tsukui, Toshihiro, Igase, Masaya

“…Immunomodulatory antibody drugs that modulate the function of immune checkpoint molecules, such as programmed death receptor-1 (PD-1) and programmed cell death…”
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Development of a cell line-based assay to measure the antibody-dependent cellular cytotoxicity of a canine therapeutic antibody by Mizuno, Takuya, Takeda, Yoshiho, Tsukui, Toshihiro, Igase, Masaya

“…Antibody drugs are one of the most important therapeutic modalities in cancer treatment. Antibody drugs for canine cytotoxicity have been developed, and the…”
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Development of a monoclonal antibody for the detection of anti-canine CD20 chimeric antigen receptor expression on canine CD20 chimeric antigen receptor-transduced T cells by SAKAI, Osamu, OGINO, Shoji, TSUKUI, Toshihiro, IGASE, Masaya, MIZUNO, Takuya

“…Chimeric antigen receptor (CAR) CAR-T cell therapy targeting CD20 can be a novel adoptive cell therapy for canine patients with B-cell malignancy. After…”
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Long‐term survival of dogs with stage 4 oral malignant melanoma treated with anti‐canine PD‐1 therapeutic antibody: A follow‐up case report by Igase, Masaya, Inanaga, Sakuya, Tani, Kenji, Nakaichi, Munekazu, Sakai, Yusuke, Sakurai, Masashi, Kato, Masahiro, Tsukui, Toshihiro, Mizuno, Takuya

“…A monoclonal antibody targeting programmed cell death‐1 (PD‐1) is one of the most promising treatments for human cancers. Clinical studies in humans…”
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Identification of cross‐reactive allergens between the Dermatophagoides farinae house dust mite and the Toxocara canis nematode in dogs with suspected allergies by Olivry, Thierry, Mas‐Fontao, Ana, Jacquenet, Sandrine, Aumayr, Martina, Tsukui, Toshihiro, Gomord, Véronique, Faye, Loïc, Favrot, Claude

“…Background Immunoglobulin (Ig)E cross‐reactivity has been shown between Dermatophagoides farinae (Df; house dust mite) and the nematode Toxocara canis (Tc),…”
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