Search Results - "Toshihide Mizoguchi"

The diverse origin of bone‐forming osteoblasts by Mizoguchi, Toshihide, Ono, Noriaki

“…ABSTRACT Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the most important functions of these metabolically active…”
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In vivo dynamics of hard tissue-forming cell origins: Insights from Cre/loxP-based cell lineage tracing studies by Mizoguchi, Toshihide

“…Bone tissue provides structural support for our bodies, with the inner bone marrow (BM) acting as a hematopoietic organ. Within the BM tissue, two types of…”
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Depletion of odontoblasts induces dental tissue regeneration by Mizoguchi, Toshihide

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Arteriolar niches maintain haematopoietic stem cell quiescence by Kunisaki, Yuya, Bruns, Ingmar, Scheiermann, Christoph, Ahmed, Jalal, Pinho, Sandra, Zhang, Dachuan, Mizoguchi, Toshihide, Wei, Qiaozhi, Lucas, Daniel, Ito, Keisuke, Mar, Jessica C., Bergman, Aviv, Frenette, Paul S.

“…Cell cycle quiescence is a critical feature contributing to haematopoietic stem cell (HSC) maintenance. Although various candidate stromal cells have been…”
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Opposing Effects of Granulocyte Colony-Stimulating Factor on the Initiation and Progression of Breast Cancer Bone Metastases by Hiraga, Toru, Ito, Susumu, Mizoguchi, Toshihide

“…Granulocyte colony stimulating factor (G-CSF), an essential cytokine regulating granulopoiesis, is expressed in a substantial proportion of breast cancers, and…”
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Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development by Mizoguchi, Toshihide, Pinho, Sandra, Ahmed, Jalal, Kunisaki, Yuya, Hanoun, Maher, Mendelson, Avital, Ono, Noriaki, Kronenberg, Henry M., Frenette, Paul S.

“…Mesenchymal stem and progenitor cells (MSPCs) contribute to bone marrow (BM) homeostasis by generating multiple types of stromal cells. MSPCs can be labeled in…”
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Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche by Hanoun, Maher, Zhang, Dachuan, Mizoguchi, Toshihide, Pinho, Sandra, Pierce, Halley, Kunisaki, Yuya, Lacombe, Julie, Armstrong, Scott A., Dührsen, Ulrich, Frenette, Paul S.

“…Perivascular mesenchymal stem and progenitor cells (MSPCs) are critical for forming a healthy hematopoietic stem cell (HSC) niche. However, the interactions…”
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Differentiation ability of Gli1+ cells during orthodontic tooth movement by Seki, Yuri, Takebe, Hiroaki, Mizoguchi, Toshihide, Nakamura, Hiroaki, Iijima, Masahiro, Irie, Kazuharu, Hosoya, Akihiro

“…Orthodontic tooth movement (OTM) induces bone formation on the alveolar bone of the tension side; however, the mechanism of osteoblast differentiation is not…”
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Vasculature-Associated Cells Expressing Nestin in Developing Bones Encompass Early Cells in the Osteoblast and Endothelial Lineage by Ono, Noriaki, Ono, Wanida, Mizoguchi, Toshihide, Nagasawa, Takashi, Frenette, Paul S., Kronenberg, Henry M.

“…Nestin-positive (Nes+) cells are important hematopoiesis-supporting constituents in adult bone marrow. However, how these cells originate during endochondral…”
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Bone formation ability of Gli1+ cells in the periodontal ligament after tooth extraction by Fujii, Saki, Takebe, Hiroaki, Mizoguchi, Toshihide, Nakamura, Hiroaki, Shimo, Tsuyoshi, Hosoya, Akihiro

“…During the process of socket healing after tooth extraction, osteoblasts appear in the tooth socket and form alveolar bone; however, the source of these…”
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RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp by Nishida, Daisuke, Arai, Atsushi, Zhao, Lijuan, Yang, Mengyu, Nakamichi, Yuko, Horibe, Kanji, Hosoya, Akihiro, Kobayashi, Yasuhiro, Udagawa, Nobuyuki, Mizoguchi, Toshihide

“…Bone-resorbing osteoclasts are regulated by the relative ratio of the differentiation factor, receptor activator NF-kappa B ligand (RANKL) and its decoy…”
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VDR in Osteoblast‐Lineage Cells Primarily Mediates Vitamin D Treatment‐Induced Increase in Bone Mass by Suppressing Bone Resorption by Nakamichi, Yuko, Udagawa, Nobuyuki, Horibe, Kanji, Mizoguchi, Toshihide, Yamamoto, Yoko, Nakamura, Takashi, Hosoya, Akihiro, Kato, Shigeaki, Suda, Tatsuo, Takahashi, Naoyuki

“…ABSTRACT Long‐term treatment with active vitamin D [1α,25(OH)2D3] and its derivatives is effective for increasing bone mass in patients with primary and…”
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Differentiation of committed osteoblast progenitors by octacalcium phosphate compared to calcium-deficient hydroxyapatite in Lepr-cre/Tomato mouse tibia by Okuyama, Kyosuke, Shiwaku, Yukari, Hamai, Ryo, Mizoguchi, Toshihide, Tsuchiya, Kaori, Takahashi, Tetsu, Suzuki, Osamu

“…This study aimed to investigate the accumulation and differentiation of mesenchymal stem cells (MSCs) around octacalcium phosphate (OCP) compared with those…”
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Parathyroid Hormone Shifts Cell Fate of a Leptin Receptor‐Marked Stromal Population from Adipogenic to Osteoblastic Lineage by Yang, Mengyu, Arai, Atsushi, Udagawa, Nobuyuki, Zhao, Lijuan, Nishida, Daisuke, Murakami, Kohei, Hiraga, Toru, Takao‐Kawabata, Ryoko, Matsuo, Koichi, Komori, Toshihisa, Kobayashi, Yasuhiro, Takahashi, Naoyuki, Isogai, Yukihiro, Ishizuya, Toshinori, Yamaguchi, Akira, Mizoguchi, Toshihide

“…ABSTRACT Intermittent parathyroid hormone (iPTH) treatment induces bone anabolic effects that result in the recovery of osteoporotic bone loss. Human PTH is…”
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The Majority of CD45– Ter119– CD31– Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors by Boulais, Philip E., Mizoguchi, Toshihide, Zimmerman, Samuel, Nakahara, Fumio, Vivié, Judith, Mar, Jessica C., van Oudenaarden, Alexander, Frenette, Paul S.

“…The non-hematopoietic cell fraction of the bone marrow (BM) is classically identified as CD45– Ter119– CD31– (herein referred to as triple-negative cells or…”
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LRP1-deficient leptin receptor-positive cells in periodontal ligament tissue reduce alveolar bone mass by inhibiting bone formation by Nishimura, Shirabe, Kariya, Hitoshi, Gakiya, Yu, Shinohara, Rie, Nakamura, Yoshiki, Mizoguchi, Toshihide, Ohashi, Akiko, Motoyoshi, Mitsuru, Ninomiya, Tadashi

“…Leptin receptor-positive (LepR ) periodontal ligament (PDL) cells play a crucial role in osteogenesis during tooth socket healing and orthodontic tooth…”
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p53 deficiency promotes bone regeneration by functional regulation of mesenchymal stromal cells and osteoblasts by Nagashima, Toshimichi, Ninomiya, Tadashi, Nakamura, Yoshiki, Nishimura, Shirabe, Ohashi, Akiko, Aoki, Junya, Mizoguchi, Toshihide, Tonogi, Morio, Takahashi, Tomihisa

“…Introduction The detailed mechanism of the process during bone healing of drill-hole injury has been elucidated, but a crucial factor in regulating drill-hole…”
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Subset of the periodontal ligament expressed leptin receptor contributes to part of hard tissue-forming cells by Oka, Hirotsugu, Ito, Shinichirou, Kawakami, Mana, Sasaki, Hodaka, Abe, Shinichi, Matsunaga, Satoru, Morita, Sumiharu, Noguchi, Taku, Kasahara, Norio, Tokuyama, Akihide, Kasahara, Masataka, Katakura, Akira, Yajima, Yasutomo, Mizoguchi, Toshihide

“…The lineage of periodontal ligament (PDL) stem cells contributes to alveolar bone (AB) and cementum formation, which are essential for tooth-jawbone…”
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Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide by Nakamura, Takashi, Honda, Sayako, Ito, Shinichirou, Mizoguchi, Toshihide, Yamamoto, Takehiro, Kasahara, Masataka, Kabe, Yasuaki, Matsuo, Koichi, Suematsu, Makoto

“…Introduction The conditional manipulation of genes using the Cre recombinase-locus of crossover in P1 (Cre/ lox P) system is an important tool for revealing…”
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Intravital fluorescence microscopy with negative contrast by Wu, Juwell W, Jung, Yookyung, Yeh, Shu-Chi A, Seo, Yongwan, Runnels, Judith M, Burns, Christian S, Mizoguchi, Toshihide, Ito, Keisuke, Spencer, Joel A, Lin, Charles P

“…Advances in intravital microscopy (IVM) have enabled the studies of cellular organization and dynamics in the native microenvironment of intact organisms with…”
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