Search Results - "Toshiaki Amamoto"

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration by Takeda, Shuso, Okajima, Shunsuke, Miyoshi, Hiroko, Yoshida, Kazutaka, Okamoto, Yoshiko, Okada, Tomoko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J., Aramaki, Hironori

“…► Cannabidiolic acid (CBDA) exists as a major component in the fiber-type cannabis. ► CBDA is identified as an “active component”. ► CBDA is an inhibitor of…”
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Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction by Hamamura, Kengo, Matsunaga, Naoya, Ikeda, Eriko, Kondo, Hideaki, Ikeyama, Hisako, Tokushige, Kazutaka, Itcho, Kazufumi, Furuichi, Yoko, Yoshida, Yuya, Matsuda, Masaki, Yasuda, Kaori, Doi, Atsushi, Yokota, Yoshifumi, Amamoto, Toshiaki, Aramaki, Hironori, Irino, Yasuhiro, Koyanagi, Satoru, Ohdo, Shigehiro

“…Chronic kidney disease (CKD) is associated with an increase in serum retinol; however, the underlying mechanisms of this disorder are poorly characterized…”
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Immune response to influenza vaccine and pneumococcal polysaccharide vaccine under IL-6 signal inhibition therapy with tocilizumab by Tsuru, Tomomi, Terao, Kimio, Murakami, Miho, Matsutani, Takaji, Suzaki, Midori, Amamoto, Toshiaki, Nakashima, Hitoshi, Akiyama, Azusa, Nishimoto, Norihiro

“…Abstract Objectives. To evaluate humoral immune response to influenza vaccine and polysaccharide pneumococcal vaccine in patients with rheumatoid arthritis…”
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Xanthocidin Derivatives as Topoisomerase IIα Enzymatic Inhibitors by Takeda, Shuso, Yaji, Kentaro, Matsumoto, Kenji, Amamoto, Toshiaki, Shindo, Mitsuru, Aramaki, Hironori

“…Few studies have examined xanthocidin, a biotic isolated from Streptomyces xanthocidicus in 1966, because its supply is limited. Based on its chemical…”
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(-)-Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells by Takeda, Shuso, Nishimura, Hajime, Koyachi, Kuniyoshi, Matsumoto, Kenji, Yoshida, Kazutaka, Okamoto, Yoshiko, Amamoto, Toshiaki, Shindo, Mitsuru, Aramaki, Hironori

“…We reported that (-)-xanthatin, a xanthanolide sesquiterpene lactone present in the Cocklebur plant, exhibited potent anti-proliferative effects on human…”
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Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease by Matsunaga, Naoya, Ikeda, Eriko, Kakimoto, Keisuke, Watanabe, Miyako, Shindo, Naoya, Tsuruta, Akito, Ikeyama, Hisako, Hamamura, Kengo, Higashi, Kazuhiro, Yamashita, Tomohiro, Kondo, Hideaki, Yoshida, Yuya, Matsuda, Masaki, Ogino, Takashi, Tokushige, Kazutaka, Itcho, Kazufumi, Furuichi, Yoko, Nakao, Takaharu, Yasuda, Kaori, Doi, Atsushi, Amamoto, Toshiaki, Aramaki, Hironori, Tsuda, Makoto, Inoue, Kazuhide, Ojida, Akio, Koyanagi, Satoru, Ohdo, Shigehiro

“…Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2…”
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Cannabidiol-2′,6′-dimethyl Ether as an Effective Protector of 15-Lipoxygenase-Mediated Low-Density Lipoprotein Oxidation in Vitro by Takeda, Shuso, Hirayama, Akari, Urata, Shino, Mano, Nobutaka, Fukagawa, Keiko, Imamura, Midori, Irii, Ayumi, Kitajima, Satomi, Masuyama, Tomoko, Nomiyama, Mai, Tatei, Sachiko, Tomita, Saari, Kudo, Taichi, Noguchi, Momoko, Yamaguchi, Yasuhiro, Okamoto, Yoshiko, Amamoto, Toshiaki, Fukunishi, Yoshifumi, Watanabe, Kazuhito, Omiecinski, Curtis John, Aramaki, Hironori

“…15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein (ox-LDL), a major causal factor for…”
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Δ9-tetrahydrocannabinol and its major metabolite Δ9-tetrahydrocannabinol-11-oic acid as 15-lipoxygenase inhibitors by Takeda, Shuso, Jiang, Rongrong, Aramaki, Hironori, Imoto, Masumi, Toda, Akihisa, Eyanagi, Reiko, Amamoto, Toshiaki, Yamamoto, Ikuo, Watanabe, Kazuhito

“…15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein, a major causal factor for…”
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Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ9-tetrahydrocannabinol in human breast cancer cells by Takeda, Shuso, Harada, Mari, Su, Shengzhong, Okajima, Shunsuke, Miyoshi, Hiroko, Yoshida, Kazutaka, Nishimura, Hajime, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J, Aramaki, Hironori

“…To investigate gene(s) being regulated by ∆9-tetrahydrocannabinol (∆9-THC), we performed DNA microarray analysis of human breast cancer MDA-MB-231 cells, which…”
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Xanthocidin Derivatives as Topoisomerase IIα Enzymatic Inhibitors by Shuso Takeda, Kentaro Yaji, Kenji Matsumoto, Toshiaki Amamoto, Mitsuru Shindo, Hironori Aramaki

“…Few studies have examined xanthocidin, a biotic isolated from Streptomyces xanthocidicus in 1966, because its supply is limited. Based on its chemical…”
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Δ(9)-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor β (ERβ) by Takeda, Shuso, Yoshida, Kazutaka, Nishimura, Hajime, Harada, Mari, Okajima, Shunsuke, Miyoshi, Hiroko, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J, Aramaki, Hironori

“…Δ(9)-Tetrahydrocannabinol (Δ(9)-THC) has been reported as possessing antiestrogenic activity, although the mechanisms underlying these effects are poorly…”
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(−)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: Role of topoisomerase IIα inhibition and reactive oxygen species by Takeda, Shuso, Noguchi, Momoko, Matsuo, Kazumasa, Yamaguchi, Yasuhiro, Kudo, Taichi, Nishimura, Hajime, Okamoto, Yoshiko, Amamoto, Toshiaki, Shindo, Mitsuru, Omiecinski, Curtis J, Aramaki, Hironori

“…Abstract Previously, we reported that (−)-xanthatin, a naturally occurring xanthanolide present in the Cocklebur plant, exhibits potent anti-proliferative…”
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(−)-Xanthatin Selectively Induces GADD45γ and Stimulates Caspase-Independent Cell Death in Human Breast Cancer MDA-MB-231 Cells by Takeda, Shuso, Matsuo, Kazumasa, Yaji, Kentaro, Okajima-Miyazaki, Shunsuke, Harada, Mari, Miyoshi, Hiroko, Okamoto, Yoshiko, Amamoto, Toshiaki, Shindo, Mitsuru, Omiecinski, Curtis J, Aramaki, Hironori

“…exo-Methylene lactone group-containing compounds, such as (−)-xanthatin, are present in a large variety of biologically active natural products, including…”
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Xanthocidin Derivatives as Topoisomerase II[alpha] Enzymatic Inhibitors by Takeda, Shuso, Yaji, Kentaro, Matsumoto, Kenji, Amamoto, Toshiaki, Shindo, Mitsuru, Aramaki, Hironori

“…Few studies have examined xanthocidin, a biotic isolated from Streptomyces xanthocidicus in 1966, because its supply is limited. Based on its chemical…”
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Δ 9 -Tetrahydrocannabinol Disrupts Estrogen-Signaling through Up-Regulation of Estrogen Receptor β (ERβ) by Takeda, Shuso, Yoshida, Kazutaka, Nishimura, Hajime, Harada, Mari, Okajima, Shunsuke, Miyoshi, Hiroko, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J., Aramaki, Hironori

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Δ9‑Tetrahydrocannabinol Disrupts Estrogen-Signaling through Up-Regulation of Estrogen Receptor β (ERβ) by Takeda, Shuso, Yoshida, Kazutaka, Nishimura, Hajime, Harada, Mari, Okajima, Shunsuke, Miyoshi, Hiroko, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J, Aramaki, Hironori

“…Δ9-Tetrahydrocannabinol (Δ9-THC) has been reported as possessing antiestrogenic activity, although the mechanisms underlying these effects are poorly…”
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Delta super(9)-Tetrahydrocannabinol Disrupts Estrogen-Signaling through Up-Regulation of Estrogen Receptor beta (ER beta ) by Takeda, Shuso, Yoshida, Kazutaka, Nishimura, Hajime, Harada, Mari, Okajima, Shunsuke, Miyoshi, Hiroko, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J, Aramaki, Hironori

“…Delta super(9)-Tetrahydrocannabinol ( Delta super(9)-THC) has been reported as possessing antiestrogenic activity, although the mechanisms underlying these…”
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Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ(9)-tetrahydrocannabinol in human breast cancer cells by Takeda, Shuso, Harada, Mari, Su, Shengzhong, Okajima, Shunsuke, Miyoshi, Hiroko, Yoshida, Kazutaka, Nishimura, Hajime, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J, Aramaki, Hironori

“…To investigate gene(s) being regulated by ∆(9)-tetrahydrocannabinol (∆(9)-THC), we performed DNA microarray analysis of human breast cancer MDA-MB-231 cells,…”
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Induction of the fatty acid 2-hydroxylase (FA2H) gene by [delta]9-tetrahydrocannabinol in human breast cancer cells by Takeda, Shuso, Harada, Mari, Su, Shengzhong, Okajima, Shunsuke, Miyoshi, Hiroko, Yoshida, Kazutaka, Nishimura, Hajime, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, J Omiecinski, Curtis, Aramaki, Hironori

“…To investigate gene(s) being regulated by [increment]9-tetrahydrocannabinol ([increment]9-THC), we performed DNA microarray analysis of human breast cancer…”
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Inductions of the fatty acid 2-hydroxylase (FA2H) gene by Δ9-tetrahydrocannabinol in human breast cancer cells by Takeda, Shuso, Harada, Mari, Su, Shengzhong, Okajima, Shunsuke, Miyoshi, Hiroko, Yoshida, Kazutaka, Nishimura, Hajime, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J, Aramaki, Hironori

“…To investigate gene(s) being regulated by Δ 9 -tetrahydrocannabinol (Δ 9 -THC), we performed DNA microarray analysis of human breast cancer MDA-MB-231 cells,…”
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