Search Results - "Toseland, Christopher P."

The mechanical response of talin by Yao, Mingxi, Goult, Benjamin T., Klapholz, Benjamin, Hu, Xian, Toseland, Christopher P., Guo, Yingjian, Cong, Peiwen, Sheetz, Michael P., Yan, Jie

“…Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion, links the actin cytoskeleton to integrin-based cell–extracellular…”
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Regulation of Nuclear Mechanics and the Impact on DNA Damage by Dos Santos, Ália, Toseland, Christopher P

“…In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical properties of the nucleus and its ability to sense external mechanical…”
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The roles of nuclear myosin in the DNA damage response by Cook, Alexander W, Toseland, Christopher P

“…Myosin within the nucleus has often been overlooked due to their importance in cytoplasmic processes and a lack of investigation. However, more recently, it…”
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DNA damage alters nuclear mechanics through chromatin reorganization by dos Santos, Ália, Cook, Alexander W, Gough, Rosemarie E, Schilling, Martin, Olszok, Nora A, Brown, Ian, Wang, Lin, Aaron, Jesse, Martin-Fernandez, Marisa L, Rehfeldt, Florian, Toseland, Christopher P

“…Abstract DNA double-strand breaks drive genomic instability. However, it remains unknown how these processes may affect the biomechanical properties of the…”
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Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA Binding by Soh, Young-Min, Bürmann, Frank, Shin, Ho-Chul, Oda, Takashi, Jin, Kyeong Sik, Toseland, Christopher P., Kim, Cheolhee, Lee, Hansol, Kim, Soo Jin, Kong, Min-Seok, Durand-Diebold, Marie-Laure, Kim, Yeon-Gil, Kim, Ho Min, Lee, Nam Ki, Sato, Mamoru, Oh, Byung-Ha, Gruber, Stephan

“…SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil,…”
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NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription by Fili, Natalia, Hari-Gupta, Yukti, dos Santos, Ália, Cook, Alexander, Poland, Simon, Ameer-Beg, Simon M., Parsons, Maddy, Toseland, Christopher P.

“…Myosin VI (MVI) has been found to be overexpressed in ovarian, breast and prostate cancers. Moreover, it has been shown to play a role in regulating cell…”
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SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis by Wilhelm, Larissa, Bürmann, Frank, Minnen, Anita, Shin, Ho-Chul, Toseland, Christopher P, Oh, Byung-Ha, Gruber, Stephan

“…Smc-ScpAB forms elongated, annular structures that promote chromosome segregation, presumably by compacting and resolving sister DNA molecules. The mechanistic…”
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Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function by Fili, Natalia, Hari-Gupta, Yukti, Aston, Bjork, dos Santos, Ália, Gough, Rosemarie E., Alamad, Bana, Wang, Lin, Martin-Fernandez, Marisa L., Toseland, Christopher P.

“…Myosin VI is involved in many cellular processes ranging from endocytosis to transcription. This multifunctional potential is achieved through alternative…”
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Atomic Force Microscopy micro-rheology reveals large structural inhomogeneities in single cell-nuclei by Lherbette, Michael, dos Santos, Ália, Hari-Gupta, Yukti, Fili, Natalia, Toseland, Christopher P., Schaap, Iwan A. T.

“…During growth, differentiation and migration of cells, the nucleus changes size and shape, while encountering forces generated by the cell itself and its…”
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Myosin VI regulates the spatial organisation of mammalian transcription initiation by Hari-Gupta, Yukti, Fili, Natalia, dos Santos, Ália, Cook, Alexander W., Gough, Rosemarie E., Reed, Hannah C. W., Wang, Lin, Aaron, Jesse, Venit, Tomas, Wait, Eric, Grosse-Berkenbusch, Andreas, Gebhardt, J. Christof M., Percipalle, Piergiorgio, Chew, Teng-Leong, Martin-Fernandez, Marisa, Toseland, Christopher P.

“…During transcription, RNA Polymerase II (RNAPII) is spatially organised within the nucleus into clusters that correlate with transcription activity. While this…”
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A survey of new PIs in the UK by Acton, Sophie E, Bell, Andrew Jd, Toseland, Christopher P, Twelvetrees, Alison

“…The challenges facing a new independent group leader, principal investigator (PI) or university lecturer are formidable: secure funding, recruit staff and…”
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Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription by dos Santos, Ália, Rollins, Daniel E., Hari-Gupta, Yukti, McArthur, Hannah, Du, Mingxue, Ru, Sabrina Yong Zi, Pidlisna, Kseniia, Stranger, Ane, Lorgat, Faeeza, Lambert, Danielle, Brown, Ian, Howland, Kevin, Aaron, Jesse, Wang, Lin, Ellis, Peter J. I., Chew, Teng-Leong, Martin-Fernandez, Marisa, Pyne, Alice L. B., Toseland, Christopher P.

“…NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in…”
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Fluorescent labeling and modification of proteins by Toseland, Christopher P.

“…This review provides an outline for fluorescent labeling of proteins. Fluorescent assays are very diverse providing the most sensitive and robust methods for…”
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Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD by Chisty, Liisa T, Toseland, Christopher P, Fili, Natalia, Mashanov, Gregory I, Dillingham, Mark S, Molloy, Justin E, Webb, Martin R

“…The helicase PcrA unwinds DNA during asymmetric replication of plasmids, acting with an initiator protein, in our case RepD. Detailed kinetics of PcrA activity…”
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A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9 by Emmanouilidis, Ioannis, Fili, Natalia, Cook, Alexander W, Hari-Gupta, Yukti, Dos Santos, Ália, Wang, Lin, Martin-Fernandez, Marisa L, Ellis, Peter J I, Toseland, Christopher P

“…Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular…”
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ATPase cycle and DNA unwinding kinetics of RecG helicase by Toseland, Christopher P, Powell, Ben, Webb, Martin R

“…The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act…”
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Unconventional Myosins: How Regulation Meets Function by Fili, Natalia, Toseland, Christopher P

“…Unconventional myosins are multi-potent molecular motors that are assigned important roles in fundamental cellular processes. Depending on their…”
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Myosin in chromosome organisation and gene expression by Shahid-Fuente, Isabel W, Toseland, Christopher P

“…The importance of myosin motor protein is well-characterised within the cytoplasm and cytoskeleton. However, mounting evidence on four nuclear myosins…”
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The ATPase Cycle of PcrA Helicase and Its Coupling to Translocation on DNA by Toseland, Christopher P., Martinez-Senac, Maria M., Slatter, Andrew F., Webb, Martin R.

“…The superfamily 1 bacterial helicase PcrA has a role in the replication of certain plasmids, acting with the initiator protein (RepD) that binds to and nicks…”
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Nuclear myosins - roles for molecular transporters and anchors by Cook, Alexander W, Gough, Rosemarie E, Toseland, Christopher P

“…The myosin family of molecular motors are well-characterised cytoskeletal proteins. However, myosins are also present in the nucleus, where they have been…”
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