Search Results - "Toscani, Denise"
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Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis
Published in Journal of hematology and oncology (08-01-2019)“…Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the…”
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The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease
Published in International journal of molecular sciences (01-03-2023)“…The study of osteoblast (OB) metabolism has recently received increased attention due to the considerable amount of energy used during the bone remodeling…”
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Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target
Published in Blood (04-08-2016)“…The importance of glutamine (Gln) metabolism in multiple myeloma (MM) cells and its potential role as a therapeutic target are still unknown, although it has…”
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Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates with Progression of Human Myeloma
Published in Molecular medicine (Cambridge, Mass.) (01-01-2016)“…Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes…”
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CD14+CD16+ monocytes are involved in daratumumab‐mediated myeloma cells killing and in anti‐CD47 therapeutic strategy
Published in British journal of haematology (01-08-2020)“…Summary A deep elucidation of the mechanisms of action of anti‐CD38 monoclonal antibodies (mAbs), such as daratumumab (DARA), is required to identify patients…”
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Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone Remodeling
Published in BioMed research international (01-01-2015)“…Multiple myeloma (MM) is characterized by a high capacity to induce alterations in the bone remodeling process. The increase in osteoclastogenesis and the…”
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The Proteasome and Myeloma-Associated Bone Disease
Published in Calcified tissue international (01-02-2018)“…Bone disease is the hallmark of multiple myeloma (MM), a hematological malignancy characterized by osteolytic lesions due to a severe uncoupled and unbalanced…”
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Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma
Published in International journal of molecular sciences (07-12-2022)“…Multiple myeloma (MM) is a monoclonal gammopathy characterized by biological heterogeneity and unregulated proliferation of plasma cells (PCs) in bone marrow…”
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The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors
Published in Journal of bone and mineral research (01-04-2016)“…ABSTRACT Multiple myeloma (MM) is characterized by severely imbalanced bone remodeling. In this study, we investigated the potential effect of proteasome…”
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Metabolic features of myeloma cells in the context of bone microenvironment: Implication for the pathophysiology and clinic of myeloma bone disease
Published in Frontiers in oncology (13-10-2022)“…Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of malignant plasma cells (PCs) into the bone marrow (BM). The complex…”
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The Role of Proteasome Inhibitors in Multiple Myeloma Bone Disease and Bone Metastasis: Effects on Osteoblasts and Osteocytes
Published in Applied sciences (01-05-2021)“…The alterations of bone remodeling are typical of multiple myeloma (MM) patients where the uncoupled and unbalanced bone remodeling caused the onset of…”
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Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response
Published in Oncoimmunology (31-12-2022)“…The humoral and cellular response to SARS-CoV-2 mRNA full vaccination and booster dose as well as the impact of the spike variants, including Omicron, are…”
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PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients
Published in Frontiers in immunology (08-01-2021)“…The PD-1/PD-L1 axis has recently emerged as an immune checkpoint that controls antitumor immune responses also in hematological malignancies. However, the use…”
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[18F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma
Published in Frontiers in oncology (12-10-2021)“…The high glycolytic activity of multiple myeloma (MM) cells is the rationale for use of Positron Emission Tomography (PET) with 18 F-fluorodeoxyglucose ([ 18…”
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Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic Targets
Published in Cells (Basel, Switzerland) (01-06-2021)“…Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) in the bone marrow (BM). The amplification of 1q21 is one of the most…”
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IL21R expressing CD14 + CD16 + monocytes expand in multiple myeloma patients leading to increased osteoclasts
Published in Haematologica (Roma) (01-04-2017)“…Bone marrow monocytes are primarily committed to osteoclast formation. It is, however, unknown whether potential primary alterations are specifically present…”
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Bovine pestivirus is a new alternative virus for multiple myeloma oncolytic virotherapy
Published in Journal of hematology and oncology (11-07-2020)“…The oncolytic viruses have shown promising results for the treatment of multiple myeloma. However, the use of human viruses is limited by the patients'…”
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Role of Osteocytes in Myeloma Bone Disease: Anti-sclerostin Antibody as New Therapeutic Strategy
Published in Frontiers in immunology (24-10-2018)“…Osteocytes are terminally differentiated cells of the osteoblast lineage. They are involved in the regulation of bone remodeling by increasing osteoclast…”
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