Search Results - "Tosca, M"

Global impact of smoke aerosols from landscape fires on climate and the Hadley circulation by Tosca, M. G, Randerson, J. T, Zender, C. S

“…Each year landscape fires across the globe emit black and organic carbon smoke particles that can last in the atmosphere for days to weeks. We characterized…”
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Predicting Tumor Volume Doubling Time and Progression-Free Survival in Untreated Patients from Patient-Derived-Xenograft (PDX) Models: A Translational Model-Based Approach by Tosca, E. M., Ronchi, D., Rocchetti, M., Magni, P.

“…Tumor volume doubling time (TVDT) has been shown to be a potential surrogate marker of biological tumor activity. However, its availability in clinics is…”
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Replacement, Reduction, and Refinement of Animal Experiments in Anticancer Drug Development: The Contribution of 3D In Vitro Cancer Models in the Drug Efficacy Assessment by Tosca, Elena M, Ronchi, Davide, Facciolo, Daniele, Magni, Paolo

“…In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a bridge between bidimensional (2D) cell cultures and in vivo animal…”
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Application of Artificial Neural Networks to Predict the Intrinsic Solubility of Drug-Like Molecules by Tosca, Elena M, Bartolucci, Roberta, Magni, Paolo

“…Machine learning (ML) approaches are receiving increasing attention from pharmaceutical companies and regulatory agencies, given their ability to mine…”
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Go beyond the limits of genetic algorithm in daily covariate selection practice by Ronchi, D., Tosca, E. M., Bartolucci, R., Magni, P.

“…Covariate identification is an important step in the development of a population pharmacokinetic/pharmacodynamic model. Among the different available…”
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Serum interleukin-17 levels are related to clinical severity in allergic rhinitis by Ciprandi, G, De Amici, M, Murdaca, G, Fenoglio, D, Ricciardolo, F, Marseglia, G, Tosca, M

“…T helper (Th)-17 cells are a subset of T helper lymphocytes that exert regulatory activities. Recently, it has been reported that serum interleukin (IL)-17…”
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Human-caused fires limit convection in tropical Africa: First temporal observations and attribution by Tosca, M. G., Diner, D. J., Garay, M. J., Kalashnikova, O. V.

“…It is well established that smoke particles modify clouds, which in turn affects climate. However, no study has quantified the temporal dynamics of…”
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Model‐based prediction of effective target exposure for MEN1611 in combination with trastuzumab in HER2‐positive advanced or metastatic breast cancer patients by Tosca, Elena M., Borella, Elisa, Piana, Chiara, Bouchene, Salim, Merlino, Giuseppe, Fiascarelli, Alessio, Mazzei, Paolo, Magni, Paolo

“…MEN1611 is a novel orally bioavailable PI3K inhibitor currently in clinical development for patients with HER2‐positive (HER2+) PI3KCA mutated…”
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Observational evidence of fire-driven reduction of cloud fraction in tropical Africa by Tosca, M. G., Diner, D. J., Garay, M. J., Kalashnikova, O. V.

“…Anthopogenic savanna fires in sub‐Saharan Africa emit smoke that affects cloudiness in the region. We measured the cloud response to fire aerosols using…”
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A Population Dynamic Energy Budget-Based Tumor Growth Inhibition Model for Etoposide Effects on Wistar Rats by Tosca, E. M., Pigatto, M. C., Dalla Costa, T., Magni, P.

“…Purpose This work aimed to develop a population PK/PD tumor-in-host model able to describe etoposide effects on both tumor cells and host in Walker-256…”
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Clinical presentation and pathogenesis of cold‐induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation by Borghini, S., Tassi, S., Chiesa, S., Caroli, F., Carta, S., Caorsi, R., Fiore, M., Delfino, L., Lasigliè, D., Ferraris, C., Traggiai, E., Di Duca, M., Santamaria, G., D'Osualdo, A., Tosca, M., Martini, A., Ceccherini, I., Rubartelli, A., Gattorno, M.

“…Objective NLRP12 mutations have been described in patients affected with peculiar autoinflammatory symptoms. This study was undertaken to characterize NLRP12…”
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Relationship between quality of life and behavioural disorders in children with persistent asthma: a Multiple Indicators Multiple Causes (MIMIC) model by Montalbano, Laura, Ferrante, Giuliana, Montella, Silvia, Cilluffo, Giovanna, Di Marco, Antonio, Bozzetto, Sara, Di Palmo, Emanuela, Licari, Amelia, Leonardi, Lucia, Caldarelli, Valeria, Ghezzi, Michele, La Grutta, Stefania, Rusconi, Franca

“…Knowledge on multiple interdependences between quality of life (QoL) and behavioural problems in relation to asthma severity and control is undetermined. The…”
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Hexavalent vaccines in preterm infants: an update by Italian Society of Pediatric Allergy and Immunology jointly with the Italian Society of Neonatology by Chiappini, E, Petrolini, C, Caffarelli, C, Calvani, M, Cardinale, F, Duse, M, Licari, A, Manti, S, Martelli, A, Minasi, D, Miraglia Del Giudice, M, Pajno, G B, Pietrasanta, C, Pugni, L, Tosca, M A, Mosca, F, Marseglia, G L

“…Hexavalent vaccines, protecting against six diseases (diphtheria, tetanus, pertussis [DTaP], poliovirus, hepatitis B virus [HBV], and Haemophilus influenzae…”
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In silico trial for the assessment of givinostat dose adjustment rules based on the management of key hematological parameters in polycythemia vera patients by Tosca, Elena M., De Carlo, Alessandro, Bartolucci, Roberta, Fiorentini, Francesco, Di Tollo, Silvia, Caserini, Maurizio, Rocchetti, Maurizio, Bettica, Paolo, Magni, Paolo

“…Polycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by excessive levels of platelets (PLT), white blood cells (WBC), and hematocrit…”
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Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules by Cipriani, F., Mastrorilli, C., Tripodi, S., Ricci, G., Perna, S., Panetta, V., Asero, R., Dondi, A., Bianchi, A., Maiello, N., Miraglia del Giudice, M., Frediani, T., Macrì, F., Lucarelli, S., Dello Iacono, I., Patria, M. F., Varin, E., Peroni, D., Chini, L., Moschese, V., Bernardini, R., Pingitore, G., Pelosi, U., Tosca, M., Paravati, F., Sfika, I., Businco, A. Di Rienzo, Povesi Dascola, C., Comberiati, P., Frediani, S., Lambiase, C., Verga, M. C., Faggian, D., Plebani, M., Calvani, M., Caffarelli, C., Matricardi, P. M.

“…Background Grass pollen‐related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities, and response to treatment…”
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Impact of allergic rhinitis on asthma: effects on bronchial hyperreactivity by Cirillo, I, Pistorio, A, Tosca, M, Ciprandi, G

“…Remarkable relationship exists between upper and lower airways. Bronchial hyperreactivity (BHR) is a paramount feature of asthma and may be considered a strong…”
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Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach by Tosca, Elena M., Gauderat, Glenn, Fouliard, Sylvain, Burbridge, Mike, Chenel, Marylore, Magni, Paolo

“…MET receptor tyrosine kinase inhibitors (TKIs) can restore sensitivity to gefitinib, a TKI targeting epidermal growth factor receptor (EGFR), and promote…”
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Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence by Prigione, I, Morandi, F, Tosca, M.A, Silvestri, M, Pistoia, V, Ciprandi, G, Rossi, G.A

“…To cite this article: Prigione I, Morandi F, Tosca MA, Silvestri M, Pistoia V, Ciprandi G, Rossi GA. Interferon-gamma and IL-10 may protect from allergic…”
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Nasal high-mobility group box-1 protein in children with allergic rhinitis by Salpietro, C, Cuppari, C, Grasso, L, Tosca, M A, Miraglia Del Giudice, M, La Rosa, M, Marseglia, G L, Salpietro, A, Ciprandi, G

“…Allergic rhinitis (AR) is characterized by an inflammatory reaction. High-mobility group box-1 protein (HMGB1) has many characteristics similar to classic…”
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Bronchial obstruction perception and uncontrolled asthma in clinical practice by Tosca, M.A., Schiavetti, I., Ciprandi, G.

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