Search Results - "Torzewski, Michael"

The Initial Human Atherosclerotic Lesion and Lipoprotein Modification-A Deep Connection by Torzewski, Michael

“…Atherosclerosis research typically focuses on the evolution of intermediate or advanced atherosclerotic lesions rather than on prelesional stages of…”
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Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis by Reustle, Anna, Torzewski, Michael

“…Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing prevalence in western societies. Statins are widely applied in…”
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C-Reactive Protein: Friend or Foe? Phylogeny From Heavy Metals to Modified Lipoproteins and SARS-CoV-2 by Torzewski, Michael

“…Animal C-reactive protein (CRP) has a widespread existence throughout phylogeny implying that these proteins have essential functions mandatory to be…”
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Fibroblasts and Their Pathological Functions in the Fibrosis of Aortic Valve Sclerosis and Atherosclerosis by Singh, Savita, Torzewski, Michael

“…Cardiovascular diseases, such as atherosclerosis and aortic valve sclerosis (AVS) are driven by inflammation induced by a variety of stimuli, including…”
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Editorial: Proven and innovative methods of ex vivo examination of atherosclerotic and aortic valve lesions by Torzewski, Michael, Fan, Jianglin, Malashicheva, Anna

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Glutathione Peroxidase-1 Deficiency Potentiates Dysregulatory Modifications of Endothelial Nitric Oxide Synthase and Vascular Dysfunction in Aging by Oelze, Matthias, Kröller-Schön, Swenja, Steven, Sebastian, Lubos, Edith, Doppler, Christopher, Hausding, Michael, Tobias, Silke, Brochhausen, Christoph, Li, Huige, Torzewski, Michael, Wenzel, Philip, Bachschmid, Markus, Lackner, Karl J, Schulz, Eberhard, Münzel, Thomas, Daiber, Andreas

“…Recently, we demonstrated that gene ablation of mitochondrial manganese superoxide dismutase and aldehyde dehydrogenase-2 markedly contributed to age-related…”
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Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice by Xia, Ning, Daiber, Andreas, Habermeier, Alice, Closs, Ellen I, Thum, Thomas, Spanier, Gerrit, Lu, Qing, Oelze, Matthias, Torzewski, Michael, Lackner, Karl J, Münzel, Thomas, Förstermann, Ulrich, Li, Huige

“…A crucial cause of the decreased bioactivity of nitric oxide (NO) in cardiovascular diseases is the uncoupling of the endothelial NO synthase (eNOS) caused by…”
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Human Oxidation-Specific Antibodies Reduce Foam Cell Formation and Atherosclerosis Progression by Tsimikas, Sotirios, MD, Miyanohara, Atsushi, PhD, Hartvigsen, Karsten, PhD, Merki, Esther, PhD, Shaw, Peter X., PhD, Chou, Meng-Yun, PhD, Pattison, Jennifer, BA, Torzewski, Michael, MD, Sollors, Janina, Friedmann, Theodore, MD, Lai, N. Chin, PhD, Hammond, H. Kirk, MD, Getz, Godfrey S., MD, PhD, Reardon, Catherine A., PhD, Li, Andrew C., MD, Banka, Carole L., PhD, Witztum, Joseph L., MD

“…Objectives We sought to assess the in vivo importance of scavenger receptor (SR)–mediated uptake of oxidized low-density lipoprotein (OxLDL) in atherogenesis…”
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Impact of glutathione peroxidase-1 deficiency on macrophage foam cell formation and proliferation: implications for atherogenesis by Cheng, Fei, Torzewski, Michael, Degreif, Adriana, Rossmann, Heidi, Canisius, Antje, Lackner, Karl J

“…Clinical and experimental evidence suggests a protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx-1) in the atherogenic process. GPx-1…”
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Diagnostic accuracy of C-reactive protein and white blood cell counts in the early detection of inflammatory complications after open resection of colorectal cancer: a retrospective study of 1,187 patients by Warschkow, Rene, Tarantino, Ignazio, Torzewski, Michael, Näf, Franziska, Lange, Jochen, Steffen, Thomas

“…Purpose Although widely used, there is a lack of evidence concerning the diagnostic accuracy of C-reactive protein (CRP) and white blood cell counts (WBCs) in…”
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Animal Models of C-Reactive Protein by Torzewski, Michael, Fan, Jianglin, Waqar, Ahmed Bilal

“…As the main theme of this special issue, CRP not only is an inflammatory marker but also has diverse biological functions associated with different diseases…”
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Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33 by Witz, Annemarie, Effertz, Denise, Goebel, Nora, Schwab, Matthias, Franke, Ulrich F W, Torzewski, Michael

“…One of the contributors to atherogenesis is enzymatically modified LDL (eLDL). eLDL was detected in all stages of aortic valve sclerosis and was demonstrated…”
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C-Reactive Protein Binds to Both Oxidized LDL and Apoptotic Cells through Recognition of a Common Ligand: Phosphorylcholine of Oxidized Phospholipids by Chang, Mi-Kyung, Binder, Christoph J., Torzewski, Michael, Witztum, Joseph L.

“…C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsular polysaccharide and…”
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Deficiency of Glutathione Peroxidase-1 Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice by Torzewski, Michael, Ochsenhirt, Viola, Kleschyov, Andrei L, Oelze, Matthias, Daiber, Andreas, Li, Huige, Rossmann, Heidi, Tsimikas, Sotirios, Reifenberg, Kurt, Cheng, Fei, Lehr, Hans-Anton, Blankenberg, Stefan, Förstermann, Ulrich, Münzel, Thomas, Lackner, Karl J

“…BACKGROUND—We have recently demonstrated that activity of red blood cell glutathione peroxidase-1 is inversely associated with the risk of cardiovascular…”
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Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice by Cheng, Fei, Twardowski, Laura, Reifenberg, Kurt, Winter, Kerstin, Canisius, Antje, Pross, Eva, Fan, Jianglin, Schmitt, Edgar, Shultz, Leonard D, Lackner, Karl J, Torzewski, Michael

“…This study focused on the unique properties of both the Ldlr knockout defect (closely mimicking the human situation) and the BALB/c (C) inbred mouse strain…”
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Overexpression of TGF-ß1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice by Reifenberg, Kurt, Cheng, Fei, Orning, Carolin, Crain, Jeanine, Küpper, Ines, Wiese, Elena, Protschka, Martina, Blessing, Manfred, Lackner, Karl J, Torzewski, Michael

“…Although macrophages represent the hallmark of both human and murine atherosclerotic lesions and have been shown to express TGF-ß1 (transforming growth factor…”
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Lipoprotein(a)-Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis by Torzewski, Michael, MD, Ravandi, Amir, MD, PhD, Yeang, Calvin, MD, PhD, Edel, Andrea, PhD, Bhindi, Rahul, MD, Kath, Stefan, MD, Twardowski, Laura, MD, Schmid, Jens, PhD, Yang, Xiaohong, BS, Franke, Ulrich F.W., MD, Witztum, Joseph L., MD, Tsimikas, Sotirios, MD

“…Visual Abstract…”
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Novel Blood Biomarkers for a Diagnostic Workup of Acute Aortic Dissection by Forrer, Anja, Schoenrath, Felix, Torzewski, Michael, Schmid, Jens, Franke, Urlich F W, Göbel, Nora, Aujesky, Drahomir, Matter, Christian M, Lüscher, Thomas F, Mach, Francois, Nanchen, David, Rodondi, Nicolas, Falk, Volkmar, von Eckardstein, Arnold, Gawinecka, Joanna

“…Acute aortic dissection (AAD) is a rare condition, but together with acute myocardial infarction (AMI) and pulmonary embolism (PE) it belongs to the most…”
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Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation by Dasari, Prasad, Heber, Sophia D., Beisele, Maike, Torzewski, Michael, Reifenberg, Kurt, Orning, Carolin, Fries, Anja, Zapf, Anna-Lena, Baumeister, Stefan, Lingelbach, Klaus, Udomsangpetch, Rachanee, Bhakdi, Sebastian Chakrit, Reiss, Karina, Bhakdi, Sucharit

“…Severe Plasmodium falciparum malaria evolves through the interplay among capillary sequestration of parasitized erythrocytes, deregulated inflammatory…”
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C-Reactive Protein and Arteriosclerosis by Torzewski, Jan, Fan, Jianglin, Schunkert, Heribert, Szalai, Alexander, Torzewski, Michael

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