Search Results - "Toru HORIE"

Manipulation and visualization of two-dimensional phase distribution of vibrational wave functions in solid parahydrogen crystal by Katsuki, Hiroyuki, Ohmori, Kenzo, Horie, Toru, Yanagi, Hisao, Ohmori, Kenji

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Non-invasive Measurement of Skin Autofluorescence as a Beneficial Surrogate Marker for Atherosclerosis in Patients with Type 2 Diabetes by Temma, Jin, Matsuhisa, Munehide, Horie, Toru, Kuroda, Akio, Mori, Hiroyasu, Tamaki, Motoyuki, Endo, Itsuro, Aihara, Ken-ichi, Abe, Masahiro, Matsumoto, Toshio

“…Advanced glycation end-products (AGEs) are thought to play a major role in the pathogenesis of diabetic vascular complications. Skin autofluorescence (AF) was…”
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Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates by Sanoh, Seigo, Santoh, Masataka, Takagi, Masashi, Kanayama, Tatsuya, Sugihara, Kazumi, Kotake, Yaichiro, Ejiri, Yoko, Horie, Toru, Kitamura, Shigeyuki, Ohta, Shigeru

“…[Display omitted] •Three dimensional cultures of hepatocyte spheroids were achieved by micro-space cell culture plates.•Comparison of mRNA expression of…”
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CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver by INOUE, Tae, NITTA, Kayoko, SUGIHARA, Kazumi, HORIE, Toru, KITAMURA, Shigeyuki, OHTA, Shigeru

“…Chimeric mice having humanized livers were constructed by transplantation of human hepatocytes. In this study, we investigated whether these mice have a…”
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EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER by KATOH, Miki, MATSUI, Tomohito, NAKAJIMA, Miki, TATENO, Chise, KATAOKA, Miho, SOENO, Yoshinori, HORIE, Toru, IWASAKI, Kazuhide, YOSHIZATO, Katsutoshi, YOKOI, Tsuyoshi

“…Recently, a chimeric mouse line in which the liver could be replaced by more than 80% with human hepatocytes was established in Japan. Because the chimeric…”
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Secretion of Albumin and Induction of CYP1A2 and CYP3A4 in Novel Three-dimensional Culture System for Human Hepatocytes using Micro-space Plate by Nishimura, Masuhiro, Hagi, Mieko, Ejiri, Yoko, Kishimoto, Sanae, Horie, Toru, Narimatsu, Shizuo, Naito, Shinsaku

“…We evaluated a novel primary three-dimensional culture system for human hepatocytes using micro-space plates. The functional activity of human hepatocytes in…”
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cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats by Büchler, M, König, J, Brom, M, Kartenbeck, J, Spring, H, Horie, T, Keppler, D

“…ATP-dependent transport of glutathione and glucuronate conjugates from hepatocytes into bile is mediated by a distinct member of the ATP-binding cassette…”
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Expression Levels of Drug-Metabolizing Enzyme, Transporter, and Nuclear Receptor mRNAs in a Novel Three-Dimensional Culture System for Human Hepatocytes Using Micro-space Plates by Nishimura, Masuhiro, Ejiri, Yoko, Kishimoto, Sanae, Suzuki, Satoshi, Satoh, Tetsuo, Horie, Toru, Narimatsu, Shizuo, Naito, Shinsaku

“…We evaluated a novel three-dimensional primary culture system using micro-space plates to determine the expression levels of 61 target (drug-metabolizing…”
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Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver by Nurrochmad, Arief, Ishii, Yuji, Nakanoh, Hitomi, Inoue, Tae, Horie, Toru, Sugihara, Kazumi, Ohta, Shigeru, Taketomi, Akinobu, Maehara, Yoshihiko, Yamada, Hideyuki

“…The formation of morphine-3-glucuronide (M-3-G, pharmacologically inactive) and morphine-6-glucuronide (M-6-G, active metabolite) by liver microsomes from…”
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IN VIVO INDUCTION OF HUMAN CYTOCHROME P450 ENZYMES EXPRESSED IN CHIMERIC MICE WITH HUMANIZED LIVER by KATOH, Miki, MATSUI, Tomohito, NAKAJIMA, Miki, TATENO, Chise, SOENO, Yoshinori, HORIE, Toru, IWASAKI, Kazuhide, YOSHIZATO, Katsutoshi, YOKOI, Tsuyoshi

“…The induction and inhibition of human cytochrome P450 (P450) enzymes are clinically responsible for drug interactions. Although the induction of P450s is…”
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Rectal angiolipoma diagnosed after surgical resection： A case report by Ishizuka, Mitsuru, Nagata, Hitoshi, Takagi, Kazutoshi, Horie, Toru, Abe, Akihito, Kubota, Keiichi

“…Angiolipoma is a common benign tumor with a characteristic vascular component that usually occurs in subcutaneous tissue. Although lipomas are frequently…”
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Distribution of glucose-6-phosphate dehydrogenase mutations in Southeast Asia by IWAI, Kuni, HIRONO, Akira, SALIM, Abdul M. A, FUJII, Hisaichi, MIWA, Shiro, ISHII, Akira, MATSUOKA, Hiroyuki, KAWAMOTO, Fumihiko, HORIE, Toru, LIN, Khin, TANTULAR, Indah S, DACHLAN, Yoes P, NOTOPURO, Harsono, HIDAYAH, Noor I

“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a heterogeneous enzyme abnormality with high frequency in tropical areas. We performed population…”
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Characterization of Humanized Liver from Chimeric Mice Using Coumarin as a Human CYP2A6 and Mouse CYP2A5 Probe by Aoki, Kimiko, Kashiwagura, Yasuharu, Horie, Toru, Sato, Hitoshi, Tateno, Chise, Ozawa, Naoki, Yoshizato, Katsutoshi

“…Coumarin 7-hydroxylation (COH), which is catalyzed almost solely by human CYP2A6 and mouse CYP2A5, shows large differences in activity (humans ≫ mice) and…”
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Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver by Inoue, Tae, Sugihara, Kazumi, Ohshita, Hiroki, Horie, Toru, Kitamura, Shigeyuki, Ohta, Shigeru

“…Chimeric mice, constructed by transplanting human hepatocytes, are useful for predicting the human metabolism of drug candidates. In this study, we…”
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Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver by KITAMURA, Shigeyuki, NITTA, Kayoko, TAYAMA, Yoshitaka, TANOUE, Chiaki, SUGIHARA, Kazumi, INOUE, Tae, HORIE, Toru, OHTA, Shigeru

“…Aldehyde oxidase-mediated oxidation of N 1 -methylnicotinamide to N 1 -methyl-2-pyridine-5-carboxamide (2-PY) and N 1 -methyl-4-pyridone-5-carboxamide (4-PY)…”
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Induction of Human CYP1A2 and CYP3A4 in Primary Culture of Hepatocytes from Chimeric Mice with Humanized Liver by Nishimura, Masuhiro, Yokoi, Tsuyoshi, Tateno, Chise, Kataoka, Miho, Takahashi, Eiji, Horie, Toru, Yoshizato, Katsutoshi, Naito, Shinsaku

“…Chimeric mice with near-completely humanized liver were constructed by transplantating hepatocytes from a Japanese and Caucasian donor. In the present study,…”
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Inflammation-Based Prognostic Score Is a Novel Predictor of Postoperative Outcome in Patients With Colorectal Cancer by ISHIZUKA, Mitsuru, NAGATA, Hitoshi, TAKAGI, Kazutoshi, HORIE, Toru, KUBOTA, Keiichi

“…To investigate the significance of preoperative Glasgow prognostic score (GPS) for postoperative prognostication of patients with colorectal cancer. Recent…”
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Total Colectomy Improves Altered Distribution of Regulatory T Cells in Patients with Ulcerative Colitis by Furihata, Makoto, Sawada, Tokihiko, Okada, Toshie, Ishizuka, Mitsuru, Horie, Toru, Takagi, Kazutoshi, Nagata, Hitoshi, Kubota, Keiichi

“…Background It is now generally believed that regulatory T cells (Tregs) play an important role in peripheral tolerance, and a defect in Tregs is considered one…”
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Kinetics of Nikkomycin Z Degradation in Aqueous Solution and in Plasma by TOKUMURA, Tadakazu, HORIE, Toru

“…The stability of nikkomycin Z in aqueous solution at various pH values and in the plasma of several kinds of experimental animals was studied. The degradation…”
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Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver by Sanoh, Seigo, Horiguchi, Aya, Sugihara, Kazumi, Kotake, Yaichiro, Tayama, Yoshitaka, Ohshita, Hiroki, Tateno, Chise, Horie, Toru, Kitamura, Shigeyuki, Ohta, Shigeru

“…Accurate prediction of pharmacokinetics (PK) parameters in humans from animal data is difficult for various reasons, including species differences. However,…”
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