Search Results - "Torturo, Christina"
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Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones
Published in British journal of anaesthesia : BJA (01-08-2019)“…P/Q- and N-type voltage-gated calcium channels (VGCC) are the principal subtypes mediating synaptic vesicle (SV) exocytosis. Both the degree of isoflurane…”
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Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca V 2.1 and Ca V 2.2 in Rat Midbrain Neurons
Published in eNeuro (01-01-2019)“…Volatile anesthetics affect neuronal signaling by poorly understood mechanisms. Activation of central dopaminergic pathways has been implicated in emergence…”
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Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to CaV2.1 and CaV2.2 in Rat Midbrain Neurons
Published in eNeuro (24-01-2019)“…Volatile anesthetics affect neuronal signaling by poorly understood mechanisms. Activation of central dopaminergic pathways has been implicated in emergence…”
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Journal Article -
4
A systematic assessment of robustness in CNS safety pharmacology
Published in British journal of pharmacology (10-10-2024)“…Irwin tests are key preclinical study elements for characterising drug-induced neurological side effects. This multicentre study aimed to assess the robustness…”
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