Search Results - "Tortorici, M Alejandra"

Structural basis for human coronavirus attachment to sialic acid receptors by Tortorici, M. Alejandra, Walls, Alexandra C., Lang, Yifei, Wang, Chunyan, Li, Zeshi, Koerhuis, Danielle, Boons, Geert-Jan, Bosch, Berend-Jan, Rey, Félix A., de Groot, Raoul J., Veesler, David

“…Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S)…”
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein by Walls, Alexandra C., Park, Young-Jun, Tortorici, M. Alejandra, Wall, Abigail, McGuire, Andrew T., Veesler, David

“…The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main…”
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Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion by Walls, Alexandra C., Tortorici, M. Alejandra, Snijder, Joost, Xiong, Xiaoli, Bosch, Berend-Jan, Rey, Felix A., Veesler, David

“…The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few decades by two global outbreaks of deadly pneumonia. The coronavirus…”
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Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding by Starr, Tyler N., Greaney, Allison J., Hilton, Sarah K., Ellis, Daniel, Crawford, Katharine H.D., Dingens, Adam S., Navarro, Mary Jane, Bowen, John E., Tortorici, M. Alejandra, Walls, Alexandra C., King, Neil P., Veesler, David, Bloom, Jesse D.

“…The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor and is a major determinant of host range and…”
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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody by Pinto, Dora, Park, Young-Jun, Beltramello, Martina, Walls, Alexandra C., Tortorici, M. Alejandra, Bianchi, Siro, Jaconi, Stefano, Culap, Katja, Zatta, Fabrizia, De Marco, Anna, Peter, Alessia, Guarino, Barbara, Spreafico, Roberto, Cameroni, Elisabetta, Case, James Brett, Chen, Rita E., Havenar-Daughton, Colin, Snell, Gyorgy, Telenti, Amalio, Virgin, Herbert W., Lanzavecchia, Antonio, Diamond, Michael S., Fink, Katja, Veesler, David, Corti, Davide

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease…”
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Structural basis for broad coronavirus neutralization by Sauer, Maximilian M., Tortorici, M. Alejandra, Park, Young-Jun, Walls, Alexandra C., Homad, Leah, Acton, Oliver J., Bowen, John E., Wang, Chunyan, Xiong, Xiaoli, de van der Schueren, Willem, Quispe, Joel, Hoffstrom, Benjamin G., Bosch, Berend-Jan, McGuire, Andrew T., Veesler, David

“…Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To…”
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Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion by Walls, Alexandra C., Xiong, Xiaoli, Park, Young-Jun, Tortorici, M. Alejandra, Snijder, Joost, Quispe, Joel, Cameroni, Elisabetta, Gopal, Robin, Dai, Mian, Lanzavecchia, Antonio, Zambon, Maria, Rey, Félix A., Corti, Davide, Veesler, David

“…Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic,…”
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Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy by Walls, Alexandra C, Tortorici, M Alejandra, Frenz, Brandon, Snijder, Joost, Li, Wentao, Rey, Félix A, DiMaio, Frank, Bosch, Berend-Jan, Veesler, David

“…Cryo-EM and mass spectrometry analyses of the spike glycoprotein trimer from coronavirus HcoV-NL63 reveal an extensive glycan shield that covers the protein…”
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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays by Crawford, Katharine H D, Eguia, Rachel, Dingens, Adam S, Loes, Andrea N, Malone, Keara D, Wolf, Caitlin R, Chu, Helen Y, Tortorici, M Alejandra, Veesler, David, Murphy, Michael, Pettie, Deleah, King, Neil P, Balazs, Alejandro B, Bloom, Jesse D

“…SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera…”
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Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein by Li, Wentao, Hulswit, Ruben J. G., Widjaja, Ivy, Raj, V. Stalin, McBride, Ryan, Peng, Wenjie, Widagdo, W., Tortorici, M. Alejandra, van Dieren, Brenda, Lang, Yifei, van Lent, Jan W. M., Paulson, James C., de Haan, Cornelis A. M., de Groot, Raoul J., van Kuppeveld, Frank J. M., Haagmans, Bart L., Bosch, Berend-Jan

“…Middle East respiratory syndrome coronavirus (MERS-CoV) targets the epithelial cells of the respiratory tract both in humans and in its natural host, the…”
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein by Walls, Alexandra C., Park, Young-Jun, Tortorici, M. Alejandra, Wall, Abigail, McGuire, Andrew T., Veesler, David

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Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc by Guardado-Calvo, Pablo, Bignon, Eduardo A, Stettner, Eva, Jeffers, Scott Allen, Pérez-Vargas, Jimena, Pehau-Arnaudet, Gerard, Tortorici, M Alejandra, Jestin, Jean-Luc, England, Patrick, Tischler, Nicole D, Rey, Félix A

“…Hantaviruses are zoonotic viruses transmitted to humans by persistently infected rodents, giving rise to serious outbreaks of hemorrhagic fever with renal…”
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Functional and evolutionary insight from the crystal structure of rubella virus protein E1 by DuBois, Rebecca M., Vaney, Marie-Christine, Tortorici, M. Alejandra, Kurdi, Rana Al, Barba-Spaeth, Giovanna, Krey, Thomas, Rey, Félix A.

“…The crystal structure of rubella virus E1 glycoprotein in its post-fusion form reveals a class II fusion protein with distinct features so far unseen in any…”
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A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis by Dubrau, Danilo, Tortorici, M Alejandra, Rey, Félix A, Tautz, Norbert

“…The viruses of the family Flaviviridae possess a positive-strand RNA genome and express a single polyprotein which is processed into functional proteins…”
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A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus by Ouizougun-Oubari, Mohamed, Pereira, Nelson, Tarus, Bogdan, Galloux, Marie, Lassoued, Safa, Fix, Jenna, Tortorici, M Alejandra, Hoos, Sylviane, Baron, Bruno, England, Patrick, Desmaële, Didier, Couvreur, Patrick, Bontems, François, Rey, Félix A, Eléouët, Jean-François, Sizun, Christina, Slama-Schwok, Anny, Duquerroy, Stéphane

“…Presently, respiratory syncytial virus (RSV), the main cause of severe respiratory infections in infants, cannot be treated efficiently with antivirals…”
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Structural insights into coronavirus entry by Tortorici, M Alejandra, Veesler, David

“…Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome…”
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Mechanism for Coordinated RNA Packaging and Genome Replication by Rotavirus Polymerase VP1 by Lu, Xiaohui, McDonald, Sarah M., Tortorici, M. Alejandra, Tao, Yizhi Jane, Vasquez-Del Carpio, Rodrigo, Nibert, Max L., Patton, John T., Harrison, Stephen C.

“…Rotavirus RNA-dependent RNA polymerase VP1 catalyzes RNA synthesis within a subviral particle. This activity depends on core shell protein VP2. A conserved…”
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Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors by Park, Young-Jun, Walls, Alexandra C., Wang, Zhaoqian, Sauer, Maximillian M., Li, Wentao, Tortorici, M. Alejandra, Bosch, Berend-Jan, DiMaio, Frank, Veesler, David

“…The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often lethal respiratory illness in humans, and no vaccines or specific…”
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N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 by McCallum, Matthew, De Marco, Anna, Lempp, Florian A., Tortorici, M. Alejandra, Pinto, Dora, Walls, Alexandra C., Beltramello, Martina, Chen, Alex, Liu, Zhuoming, Zatta, Fabrizia, Zepeda, Samantha, di Iulio, Julia, Bowen, John E., Montiel-Ruiz, Martin, Zhou, Jiayi, Rosen, Laura E., Bianchi, Siro, Guarino, Barbara, Fregni, Chiara Silacci, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Rothlauf, Paul W., Bloyet, Louis-Marie, Benigni, Fabio, Cameroni, Elisabetta, Neyts, Johan, Riva, Agostino, Snell, Gyorgy, Telenti, Amalio, Whelan, Sean P.J., Virgin, Herbert W., Corti, Davide, Pizzuto, Matteo Samuele, Veesler, David

“…The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19…”
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Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer by Walls, Alexandra C., Tortorici, M. Alejandra, Bosch, Berend-Jan, Frenz, Brandon, Rottier, Peter J. M., DiMaio, Frank, Rey, Félix A., Veesler, David

“…The high-resolution cryo-electron microscopy structure of a pre-fusion coronavirus spike trimer from mouse hepatitis virus is presented; the structure reveals…”
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